Infective endocarditis and oral health: a long-known threat, still a challenge
Monaldi Archives for Chest Disease,
Год журнала:
2025,
Номер
unknown
Опубликована: Май 27, 2025
Infective
endocarditis
(IE)
remains
a
life-threatening
condition
associated
with
high
morbidity
and
mortality,
often
influenced
by
the
complex
interplay
between
systemic
oral
health.
The
increasing
recognition
of
health
as
risk
modifier
has
led
to
greater
focus
on
microbiome,
dental
procedures,
periodontal
disease
potential
contributors
bacteremia
IE.
This
review
critically
examines
relationship
IE,
exploring
pathophysiological
mechanisms,
factors,
evolving
epidemiology
disease.
discussion
includes
diagnostic
challenges,
particularly
in
culture-negative
cases,
emerging
role
advanced
imaging
molecular
diagnostics
improving
early
detection.
A
central
is
placed
preventive
strategies,
highlighting
debate
surrounding
antibiotic
prophylaxis
(AP)
high-risk
individuals
therapy
reducing
inflammation
transient
bacteremia.
also
addresses
growing
concern
antimicrobial
resistance
necessity
balancing
AP
recommendations
stewardship.
Additionally,
this
identifies
critical
research
gaps,
including
need
for
longitudinal
studies
impact
interventions
IE
incidence
importance
interdisciplinary
collaboration
medical
professionals
optimizing
patient
care.
By
synthesizing
current
guidelines
evidence,
underscores
an
integrated,
multidisciplinary
approach
mitigate
burden
establish
key
pillar
infection
prevention.
Язык: Английский
A retrospective analysis of the incidence and risk factors of perioperative urinary tract infections after total hysterectomy
Xianghua Cao,
Yunyun Tu,
Xinyao Zheng
и другие.
BMC Women s Health,
Год журнала:
2024,
Номер
24(1)
Опубликована: Май 29, 2024
Abstract
Introduction
Perioperative
urinary
tract
infections
(PUTIs)
are
common
in
the
United
States
and
a
significant
contributor
to
high
healthcare
costs.
There
is
lack
of
large
studies
on
risk
factors
for
PUTIs
after
total
hysterectomy
(TH).
Methods
We
conducted
retrospective
study
using
national
inpatient
sample
(NIS)
445,380
patients
from
2010
2019
analyze
annual
incidence
associated
with
TH
perioperatively.
Results
were
found
9087
overall,
showing
2.0%
incidence.
substantial
differences
based
age
group
(
P
<
0.001).
Between
two
groups,
there
was
consistently
difference
type
insurance,
hospital
location,
bed
size,
Patients
exhibited
significantly
higher
number
comorbidities
Unsurprisingly,
had
longer
median
length
stay
(5
days
vs.
2
days;
0.001)
in-hospital
death
rate
(from
0.1
1.1%;
Thus,
overall
hospitalization
expenditures
increased
by
$27,500
($60,426
$32,926,
as
medical
Elective
hospitalizations
less
(66.8%
87.6%;
According
multivariate
logistic
regression
study,
following
variables
TH:
over
45
years
old;
(≥
1);
size
(medium,
large);
teaching
hospital;
region
hospital(south,
west);
preoperative
(alcohol
abuse,
deficiency
anemia,
chronic
blood
loss
congestive
heart
failure,
diabetes,
drug
hypertension,
hypothyroidism,
lymphoma,
fluid
electrolyte
disorders,
metastatic
cancer,
other
neurological
paralysis,
peripheral
vascular
psychoses,
pulmonary
circulation
renal
solid
tumor
without
metastasis,
valvular
disease,
weight
loss);
complications
(sepsis,
acute
myocardial
infarction,
deep
vein
thrombosis,
gastrointestinal
hemorrhage,
pneumonia,
stroke,
wound
infection,
rupture,
embolism,
transfusion,
postoperative
delirium).
Conclusions
The
findings
suggest
that
identifying
these
can
lead
improved
preventive
strategies
management
patients.
Counseling
should
be
done
prior
surgery
reduce
PUTIs.
manuscript
adds
current
knowledge
In
practice,
identification
patient
prevention
treatment
strategies.
noted
stay,
cost,
pre-existing
comorbidities,
hospital,
hospitals,
also
play
role
UTI’s.
Clinical
topics
Urogynecology
Язык: Английский
New resorcylic acid derivatives of Lysimachia tengyuehensis against MRSA and VRE by interfering with bacterial metabolic imbalance
European Journal of Medicinal Chemistry,
Год журнала:
2024,
Номер
277, С. 116714 - 116714
Опубликована: Июль 31, 2024
Язык: Английский
Current innovations in mRNA vaccines for targeting multidrug-resistant ESKAPE pathogens
Biotechnology Advances,
Год журнала:
2024,
Номер
unknown, С. 108492 - 108492
Опубликована: Дек. 1, 2024
The
prevalence
of
multidrug-resistant
(MDR)
ESKAPE
pathogens,
including
Enterococcus
faecium,
Staphylococcus
aureus,
Klebsiella
pneumoniae,
Acinetobacter
baumannii,
and
Pseudomonas
aeruginosa,
represents
a
critical
global
public
health
challenge.
In
response,
mRNA
vaccines
offer
an
adaptable
scalable
platform
for
immunotherapy
against
pathogens
by
encoding
specific
antigens
that
stimulate
B-cell-driven
antibody
production
CD8
Язык: Английский