The Chemical Record,
Год журнала:
2024,
Номер
unknown
Опубликована: Фев. 5, 2024
Nanotechnology
has
emerged
as
a
pivotal
tool
in
biomedical
research,
particularly
developing
advanced
sensing
platforms
for
disease
diagnosis
and
therapeutic
monitoring.
Since
gold
nanoparticles
are
biocompatible
have
special
optical
characteristics,
they
excellent
choices
surface-enhanced
Raman
scattering
(SERS)
devices.
Integrating
fluorescence
characteristics
further
enhances
their
utility
real-time
imaging
tracking
within
biological
systems.
The
synergistic
combination
of
SERS
enables
sensitive
selective
detection
biomolecules
at
trace
levels,
providing
versatile
platform
early
cancer
drug
In
detection,
AuNPs
facilitate
the
specific
targeting
biomarkers,
allowing
early-stage
personalized
treatment
strategies.
enhanced
sensitivity
SERS,
coupled
with
tunable
properties
AuNPs,
offers
powerful
identification
cells
microenvironment.
This
dual-mode
not
only
improves
diagnostic
accuracy
but
also
monitoring
response
progression.
integrating
provides
robust
identifying
quantifying
pharmaceutical
compounds.
unique
spectral
fingerprints
obtained
through
enable
discrimination
molecules
even
complex
matrices.
Furthermore,
property
makes
it
easier
to
track
medication
distribution
real-time,
maximizing
effectiveness
reducing
adverse
effects.
review
explores
role
photodynamic
therapy
(PDT).
By
using
complementary
effects
targeted
release
light-induced
cytotoxicity,
SERS-guided
delivery
(PDT)
can
increase
against
cells.
conclusion,
utilization
conjunction
holds
tremendous
potential
revolutionizing
analysis,
therapy.
capabilities
these
nanomaterials
provide
multifaceted
approach
address
challenges
diagnosis,
monitoring,
medicine,
thereby
advancing
landscape
applications.
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Июль 11, 2024
Cancer,
being
one
of
the
deadliest
diseases,
poses
significant
challenges
despite
existence
traditional
treatment
approaches.
This
has
led
to
a
growing
demand
for
innovative
pharmaceutical
agents
that
specifically
target
cancer
cells
effective
treatment.
In
recent
years,
use
metal
nanoparticles
(NPs)
as
promising
alternative
conventional
therapies
gained
prominence
in
research.
Metal
NPs
exhibit
unique
properties
hold
tremendous
potential
various
applications
Studies
have
demonstrated
certain
metals
possess
inherent
or
acquired
anticancer
capabilities
through
their
surfaces.
These
make
an
attractive
focus
therapeutic
development.
this
review,
we
will
investigate
applicability
several
distinct
classes
tumor
targeting
may
include
gold,
silver,
iron
oxide,
and
other
with
can
be
exploited
purposes.
Additionally,
provide
comprehensive
summary
risk
factors
associated
application
NPs.
Understanding
addressing
these
crucial
successful
clinical
translation
mitigate
any
failures
NP-based
therapies.
By
exploring
identifying
factors,
review
aims
contribute
advancement
strategies.
The
anticipated
outcome
is
valuable
insights
pave
way
targeted
utilizing
patients.
Advanced Healthcare Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Июнь 10, 2024
The
recent
decade
has
witnessed
a
remarkable
surge
in
the
field
of
nanoparticles,
from
their
synthesis,
characterization,
and
functionalization
to
diverse
applications.
At
nanoscale,
these
particles
exhibit
distinct
physicochemical
properties
compared
bulk
counterparts,
enabling
multitude
applications
spanning
energy,
catalysis,
environmental
remediation,
biomedicine,
beyond.
This
review
focuses
on
specific
nanoparticle
categories,
including
magnetic,
gold,
silver,
quantum
dots
(QDs),
as
well
hybrid
variants,
specifically
tailored
for
biomedical
A
comprehensive
comparison
prevalent
chemical,
physical,
biological
synthesis
methods
are
presented.
To
enhance
biocompatibility
colloidal
stability,
facilitate
surface
modification
cargo/agent
loading,
surfaces
coated
with
different
synthetic
polymers
very
recently,
cell
membrane
coatings.
utilization
polymer-
or
membrane-coated
nanoparticles
opens
wide
variety
such
magnetic
resonance
imaging
(MRI),
hyperthermia,
photothermia,
sample
enrichment,
bioassays,
drug
delivery,
etc.
With
this
review,
goal
is
provide
toolbox
insights
into
polymer
applications,
while
also
addressing
challenges
involved
translating
laboratory
benchtops
vitro
vivo
Furthermore,
perspectives
future
trends
developments
rapidly
evolving
domain
provided.
Heliyon,
Год журнала:
2025,
Номер
11(4), С. e42738 - e42738
Опубликована: Фев. 1, 2025
In
recent
decades,
significant
attention
has
been
directed
towards
gold
nanoparticles
due
to
their
exceptional
properties,
capturing
the
interest
of
researchers
globally.
Their
unique
characteristics,
such
as
localized
surface
plasmon
resonance,
high
area
volume
ratio,
biocompatibility,
and
facile
functionalization,
render
them
highly
suitable
for
diverse
applications,
ranging
from
optoelectronics
sensing
surface-enhanced
spectroscopies
biomedical
uses,
particularly
in
realm
photothermal
therapy.
Plasmonic
therapy,
an
emerging
technology,
garnered
substantial
its
potential
cancer
treatment
management.
This
approach
employs
agents,
nanoparticles,
which
absorb
light
near-infrared
region.
When
these
agents
accumulate
within
cells,
absorbed
photon
energy
is
converted
into
heat,
inducing
local
hyperthermia.
effect
selectively
eliminates
damaged
cells
adjacent
while
sparing
normal
cells.
Various
shapes
sizes
have
proven
well-suited
candidates
paper
provides
overview
distinctive
properties
nanoparticles.
It
delves
functionalization
techniques
crucial
ensuring
cells'
effective
retention
targeting
this
context,
present
reviews
applications
with
different
plasmonic
encompassing
nanospheres,
nanorods,
nanoshells,
nanostars,
nanocages.
ACS Omega,
Год журнала:
2021,
Номер
6(26), С. 16847 - 16853
Опубликована: Июнь 24, 2021
The
synthesis
of
gold
nanoparticles
is
dependent
on
both
the
concentration
trisodium
citrate
dihydrate
and
time
that
it
interacts
with
tetrachloroauric
acid.
A
wide
range
various
sizes
dispersity
can
be
produced
based
control
variables,
such
as
reaction
acid
concentration,
using
a
similar
approach
to
Turkevich
model.
In
this
model,
pH
solution
decreases
slightly
throughout
(0.005
unit/min)
due
chemical
interactions
between
Dicarboxy
acetone
formed
during
oxidization,
resulting
in
nuclei
formation
over
time.
addition,
nanoparticle
nucleation
causes
fluctuation
sizes.
An
inverse
correlation
(coefficient
smaller
than
−0.97)
was
calculated
at
different
ratios
Regression
analysis
used
develop
model
for
prediction
size
ranging
from
18
38
nm
Molecules,
Год журнала:
2021,
Номер
26(11), С. 3085 - 3085
Опубликована: Май 21, 2021
Cancer
theranostics
is
a
new
concept
of
medical
approach
that
attempts
to
combine
in
unique
nanoplatform
diagnosis,
monitoring
and
therapy
so
as
provide
eradication
solid
tumor
non-invasive
fashion.
There
are
many
available
solutions
tackle
cancer
using
theranostic
agents
such
photothermal
(PTT)
photodynamic
(PDT)
under
the
guidance
imaging
techniques
(e.g.,
magnetic
resonance-MRI,
photoacoustic-PA
or
computed
tomography-CT
imaging).
Additionally,
there
several
potential
nanoplatforms
able
diagnosis
at
once,
gold
nanoparticles
(GNPs),
graphene
oxide
(GO),
superparamagnetic
iron
(SPIONs)
carbon
nanodots
(CDs).
Currently,
surface
functionalization
these
an
extremely
useful
protocol
for
effectively
tuning
their
structures,
interface
features
physicochemical
properties.
This
much
more
reliable
amenable
fine
adjustment,
reaching
both
regulatory
requirements
function
specific
field
application.
Here,
we
summarize
compare
most
promising
metal-
carbon-based
tools
reported
candidates
precision
theranostics.
We
focused
our
review
on
latest
developments
strategies
nanosystems,
hybrid
nanocomposites
consisting
combination,
discuss
main
characteristics
applications
medicine.
Wiley Interdisciplinary Reviews Nanomedicine and Nanobiotechnology,
Год журнала:
2022,
Номер
15(1)
Опубликована: Авг. 5, 2022
Abstract
Advances
in
nanotechnology
and
medical
science
have
spurred
the
development
of
engineered
nanomaterials
nanoparticles
with
particular
focus
on
their
applications
biomedicine.
In
particular,
gold
(AuNPs)
been
great
interest,
due
to
exquisite
intrinsic
properties,
such
as
ease
synthesis
surface
functionalization,
tunable
size
shape,
lack
acute
toxicity
favorable
optical,
electronic,
physicochemical
features,
which
possess
value
for
application
biodetection
diagnostics
purposes,
including
molecular
sensing,
photoimaging,
under
form
portable
simple
biosensors
(e.g.,
lateral
flow
immunoassays
that
extensively
exploited
during
current
COVID‐19
pandemic).
We
shall
discuss
main
properties
AuNPs,
conjugation
biorecognition
moieties,
trends
sensing
detection
biomedicine
diagnostics.
This
article
is
categorized
under:
Diagnostic
Tools
>
Biosensing
Vitro
Nanoparticle‐Based
Sensing
Vivo
Nanodiagnostics
Imaging
Abstract
Cancer
is
a
disease
associated
with
complex
pathology
and
one
of
the
most
prevalent
leading
reasons
for
mortality
in
world.
Current
chemotherapy
has
challenges
cytotoxicity,
selectivity,
multidrug
resistance,
formation
stemlike
cells.
Nanomaterials
(NMs)
have
unique
properties
that
make
them
useful
various
diagnostic
therapeutic
purposes
cancer
research.
NMs
can
be
engineered
to
target
cells
early
detection
deliver
drugs
directly
cells,
reducing
side
effects
improving
treatment
efficacy.
Several
also
used
photothermal
therapy
destroy
or
enhance
immune
response
by
delivering
immune‐stimulating
molecules
modulating
tumor
microenvironment.
are
being
modified
overcome
issues,
such
as
toxicity,
lack
increase
drug
capacity,
bioavailability,
wide
spectrum
therapies.
To
improve
targeted
delivery
using
nano‐carriers,
noteworthy
research
required.
metal‐based
been
studied
expectation
finding
cure
treatment.
In
this
review,
current
development
potential
plant
their
on
size
shape
discussed
along
more
effective
usage
diagnosis
Chemistry & Biodiversity,
Год журнала:
2023,
Номер
20(6)
Опубликована: Март 1, 2023
Abstract
In
this
review,
we
discuss
Nanotechnology
models,
which
have
been
developed
recently
in
cancer
treatment.
manipulates
matter
at
the
atomic
and
molecular
scale
to
create
materials
with
new
advanced
properties.
Nano‐biotechnology
consists
of
branches
nanotechnology
that
applied
biology
(molecular
cellular
genetics)
biotechnology.
allows
us
put
components
compounds
into
cells
build
using
methods
like
assembly.
Cancer
is
a
disease
caused
by
an
uncontrolled
division
abnormal
part
body.
Its
therapeutic
include
chemotherapy,
radiation,
or
surgery,
but
effects
these
techniques
are
not
only
on
tumor
tissue
may
affect
healthy
tissues.
Nano‐Biotech
applications
regarding
drug
delivery,
treatment,
foresight
therapy.
This
review
article
aims
obtain
proper
mentality
current
technologies
for
