Potential of Chitosan/Gelatin-Based Nanofibers in Delivering Drugs for the Management of Varied Complications: A Review
Polymers,
Год журнала:
2025,
Номер
17(4), С. 435 - 435
Опубликована: Фев. 7, 2025
Drug
delivery
systems
have
revolutionized
traditional
drug
administration
methods
by
addressing
various
challenges,
such
as
enhancing
solubility,
prolonging
effectiveness,
minimizing
adverse
effects,
and
preserving
potency.
Nanotechnology-based
systems,
particularly
nanoparticles
(NPs)
nanofibers
(NFs),
emerged
promising
solutions
for
biomedicine
delivery.
NFs,
with
their
ability
to
mimic
the
porous
fibrous
structures
of
biological
tissues,
garnered
significant
interest
in
drug-delivering
applications.
Biopolymers
gelatin
(Ge)
chitosan
(CH)
gained
much
more
attention
due
biocompatibility,
biodegradability,
versatility
biomedical
CH
exhibits
exceptional
anti-bacterial
activity,
wound
healing
capabilities,
whereas
Ge
provides
good
biocompatibility
cell
adhesion
properties.
Ge/CH-based
NFs
stimulate
cellular
connections
facilitate
tissue
regeneration
owing
structural
resemblance
extracellular
matrix.
This
review
explores
additive
preparation,
including
electrospinning,
force
pinning,
template
synthesis,
focusing
on
electrospinning
factors
influencing
fiber
structure.
The
properties
CH,
role
release,
formulation
strategies,
characterization
techniques
electrospun
fibers
are
discussed.
Furthermore,
this
addresses
applications
delivering
active
moieties
management
orthopedics
regulatory
considerations,
along
challenges
related
them.
Thus,
aims
provide
a
comprehensive
overview
potential
Язык: Английский
Fabrication of Chitosan/PEO/Rosmarinic acid based nanofibrous mat for diabetic burn wound healing and its anti-bacterial efficacy in mice
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 140416 - 140416
Опубликована: Янв. 1, 2025
Язык: Английский
Fabrication and in Vivo Evaluation of Hybrid Squalene-Loaded Nanofiber Scaffolds Based on Poly(ε-Caprolactone)/Polyvinyl Alcohol/Chitosan for Wound Healing Applications
Journal of Polymers and the Environment,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 6, 2025
Язык: Английский
Tri-layer gradient fibre-aligned electrospun composite: Accelerating skin wound healing
Materials Today Communications,
Год журнала:
2025,
Номер
45, С. 112320 - 112320
Опубликована: Апрель 1, 2025
Язык: Английский
Safety and feasibility of electrospinning technology for pediatric burns: Insights from a retrospective cohort study
Burns,
Год журнала:
2025,
Номер
unknown, С. 107509 - 107509
Опубликована: Апрель 1, 2025
Язык: Английский
Nanofiber Application in Wound Healing
IGI Global eBooks,
Год журнала:
2025,
Номер
unknown, С. 289 - 326
Опубликована: Апрель 11, 2025
Nanofiber
technology
presents
significant
potential
across
various
medical
applications,
with
particular
emphasis
on
its
role
in
wound
healing.
This
chapter
examines
the
ability
of
nanofibers
to
mimic
extracellular
matrix,
facilitating
critical
processes
such
as
cell
adhesion,
migration,
nutrient
and
oxygen
delivery,
inflammation
modulation,
controlled
release
bioactive
molecules.
These
properties
position
optimal
candidates
for
advanced
dressings,
biodegradable
scaffolds,
cell-seeded
constructs.
Empirical
studies
substantiate
their
efficacy
mitigating
inflammation,
preventing
infections,
minimizing
scar
formation.
However,
challenges
persist,
including
issues
related
scalability,
cost-effectiveness,
mechanical
stability,
biocompatibility,
regulatory
approval.
concludes
by
addressing
these
outlining
research
gaps
that
must
be
bridged
fully
harness
nanofiber
technology,
particularly
long-term
safety,
mechanistic
insights,
adaptation
low-resource
settings.
Язык: Английский
Role of Biomaterials in Promoting Wound Healing
IGI Global eBooks,
Год журнала:
2025,
Номер
unknown, С. 367 - 412
Опубликована: Апрель 25, 2025
Because
biomaterials
can
improve
tissue
repair
and
regeneration,
their
use
in
wound
healing
has
drawn
much
attention.
Biomaterials
facilitate
cellular
connections,
create
favorable
microenvironments,
offer
mechanical
support,
making
them
vital
for
promoting
healing.
These
materials
fall
into
three
categories:
natural,
synthetic,
hybrid.
Natural
polymers
such
as
collagen,
alginate,
chitosan
mimic
the
extracellular
matrix
biocompatibility,
while
synthetic
like
PLGA
provide
adjustable
qualities
strength
degradation
rates.
Advanced
hydrogels,
nanoparticles,
electrospun
fibers
enhance
moisture
retention,
control
drug
release,
reduce
infection.
They
release
bioactive
chemicals
growth
factors
antimicrobial
peptides,
preventing
chronic
wounds.
This
chapter
examines
various
used
healing,
therapeutic
uses,
modes
of
action,
well
future
developments
challenges
design,
scalability.
Язык: Английский
Imino-quaternized chitosan/chitosan nanofibers loaded with norfloxacin as potential bandages for wound healing
International Journal of Biological Macromolecules,
Год журнала:
2025,
Номер
unknown, С. 144304 - 144304
Опубликована: Май 1, 2025
Due
to
the
critical
need
for
effective
wound
dressings
management
of
burn
injuries,
this
paper
focuses
on
addressing
key
gaps
in
infection
prevention
and
control.
The
study
aims
develop
advanced
nanofibrous
based
quaternized
chitosan/chitosan,
loaded
with
norfloxacin
modified
2-formylphenylboronic
acid
enhance
antimicrobial
antioxidant
activity
promote
healing.
materials
combine
beneficial
properties
chitosan/quaternized
chitosan,
such
as
biocompatibility,
biodegradability,
activity.
characterization
was
performed
from
structural
(NMR,
FTIR,
UV-Vis
spectroscopy
thermogravimetric
analysis),
morphological
(SEM,
water
vapor
sorption)
supramolecular
points
view
(X-Ray
Diffraction
Polarized
Microscopy).
Essential
were
evaluated
proved
excellent
performances,
Young's
modulus
up
1250
MPa,
swelling
capacity
till
6
g/g,
radical
scavenging
70
%
enzymatic
degradability
53
21
days.
fibers
presented
antibacterial
properties,
reflected
by
high
inhibition
zones
against
Escherichia
coli
(40
mm)
Staphylococcus
aureus
(34
antifungal
Candida
glabrata
(15
mm).
Preliminary
studies
demonstrated
vitro
safety
Human
Gingival
Fibroblasts,
while
vivo
experiments
Wistar
rats
confirmed
biocompatibility
materials,
emphasizing
their
potential
burns.
Язык: Английский
Antimicrobial Smart Dressings for Combating Antibiotic Resistance in Wound Care
Pharmaceuticals,
Год журнала:
2025,
Номер
18(6), С. 825 - 825
Опубликована: Май 30, 2025
Wound
healing
is
a
complex,
tightly
regulated
process
essential
for
maintaining
skin
barrier
function.
Chronic
wounds,
often
complicated
by
biofilm-forming
bacteria
and
elevated
oxidative
stress,
pose
significant
challenges
in
clinical
management.
The
rise
of
antibiotic-resistant
has
further
exacerbated
the
problem,
limiting
therapeutic
options
complicating
wound
treatment.
Traditional
care
approaches
frequently
fail
to
provide
real-time
accurate
insights
into
status,
leading
delayed
or
suboptimal
treatments.
Recent
advancements
modern
smart
dressings,
which
integrate
various
biosensors,
different
new
drug
delivery
systems,
wireless
communication
technology,
offers
promising
solutions
monitoring
progression
over
time.
These
innovations
enable
early
detection
adverse
events
such
as
bacterial
infections
inflammation,
facilitating
more
effective,
on-demand
This
review
highlights
current
state
antibiotic-embedded
discusses
their
limitations,
explores
potential
next-generation
dressings
incorporating
microelectronic
sensors
adaptive
responses
support
combat
antimicrobial
resistance.
Язык: Английский