Role of next‐generation sequencing in revolutionizing healthcare for cancer management
MedComm – Future Medicine,
Год журнала:
2024,
Номер
3(4)
Опубликована: Ноя. 23, 2024
Abstract
Next‐generation
sequencing
(NGS)
has
emerged
as
a
transformative
technology
in
oncology,
revolutionizing
cancer
diagnostics
and
personalized
treatment
strategies.
By
providing
comprehensive
insights
into
the
genetic
landscape
of
tumors,
NGS
enables
identification
critical
somatic
germline
mutations,
copy
number
variations
(CNVs),
gene
fusions.
Over
past
decade,
advancements
platforms
have
led
to
greater
accuracy,
speed,
cost‐effectiveness,
making
it
an
integral
part
research
clinical
diagnostics.
Despite
its
widespread
adoption,
significant
challenges
remain,
including
need
for
improved
methods
detect
minimal
residual
disease
(MRD)
accurately
profile
tumor
heterogeneity.
This
review
explores
evolution
technologies
their
pivotal
role
biology,
from
early
therapeutic
guidance.
It
delves
application
identifying
CNVs
fusions,
monitoring
MRD,
increasing
relevance
targeted
spatial
genomics.
Furthermore,
integration
transcriptomics
is
highlighted
frontier
understanding
microenvironment.
addressing
these
aspects,
this
provides
overview
how
shaping
future
treatment,
offering
complete
potential
applications
scientific
oncology.
Язык: Английский
Immunobiology of MPox Infection and Its Management: Experience From Developing Nations
Reviews in Medical Virology,
Год журнала:
2025,
Номер
35(1)
Опубликована: Янв. 1, 2025
ABSTRACT
Purpose
As
humanity
grapples
with
the
COVID‐19
pandemic
caused
by
novel
SARS‐CoV‐2
virus,
rising
threats
of
MPox
virus
(MPXV)
in
2022
and
2024
have
shown
signs
global
transmission
potential
to
spark
another
pandemic.
Though
MPXV
has
been
present
for
over
5
decades,
cases
traditionally
confined
endemic
regions
West
Central
Africa,
recent
outbreaks
occurred
multiple
non‐endemic
regions,
declaring
itself
as
a
Public
Health
Emergency
International
Concern.
This
study
aims
examine
patterns
transmission,
its
zoonotic
potential,
associated
complications,
viable
strategies
control
spread.
Methods
The
examines
outbreak
data,
case
reports,
literature
on
emphasising
pathways
healthcare‐associated
cases.
A
bibliometric
analysis
also
performed
deepen
understanding
identify
emerging
research
trends.
Results
findings
suggest
that
while
certain
indicate
an
increased
risk
countries,
raising
concerns
about
Data
reveals
much
within
healthcare
settings.
Additionally,
remains
limited
requires
further
exploration
from
various
perspectives,
need
prompt
intervention.
Conclusion
Containing
MPXV's
spread
is
essential
prevent
Effective
management
strategies,
including
enhanced
surveillance,
public
health
interventions,
targeted
education
at‐risk
communities,
are
critical
mitigate
impact
globally.
advocates
proactive
approach
avoid
escalation
into
widespread
crisis.
Язык: Английский
Genomic evidence for hybridization and introgression between blue peafowl and endangered green peafowl and molecular foundation of leucistic plumage of blue peafowl
GigaScience,
Год журнала:
2025,
Номер
14
Опубликована: Янв. 1, 2025
Abstract
Introduction
The
blue
peafowl
(Pavo
cristatus)
and
the
green
muticus)
have
garnered
significant
public
affection
due
to
their
stunning
appearance,
although
is
currently
endangered.
causative
mutation
that
causes
leucistic
plumage
of
(also
called
white
peafowl)
remains
unknown.
Results
In
this
study,
we
generated
a
chromosome-level
reference
genome
with
contig
N50
30.6
Mb,
including
autosomes,
Z
W
sex
chromosomes,
complete
mitochondria
DNA
sequence.
Data
from
77
whole
genomes,
76
mitochondrial
33
chromosomes
genomes
provided
first
substantial
genetic
evidence
for
recent
hybridization
between
peafowls
peafowls.
We
found
3
hybrid
in
zoo
samples
rather
than
wild
samples,
genomic
content
16–34%.
Maternal
analysis
showed
2
female
contained
chromosomes.
Some
animal
protection
agencies
release
captive
order
maintain
population
Therefore,
better
protect
endangered
peafowl,
suggest
purebred
identification
must
be
carried
out
before
releasing
zoos
into
prevent
contaminating
peafowl.
addition,
also
there
were
historical
introgression
events
4
individuals.
introgressed
regions
contain
IGFBP1
IGFBP3
genes
could
affect
body
size.
Finally,
identified
nonsense
(g.4:12583552G>A)
EDNRB2
gene
preventing
melanocytes
being
transported
plumage,
thereby
inhibiting
melanin
deposition.
Conclusion
Our
research
provides
both
theoretical
empirical
support
conservation
high-quality
data
provide
valuable
resource
genomics-assisted
breeding.
Язык: Английский