Dendritic mGluR2 and perisomatic Kv3 signaling regulate dendritic computation of mouse starburst amacrine cells DOI Creative Commons
Héctor Acarón Ledesma, Jennifer Ding, Swen Oosterboer

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Фев. 28, 2024

Abstract Dendritic mechanisms driving input-output transformation in starburst amacrine cells (SACs) are not fully understood. Here, we combine two-photon subcellular voltage and calcium imaging electrophysiological recording to determine the computational architecture of mouse SAC dendrites. We found that perisomatic region integrates motion signals over entire dendritic field, providing a low-pass-filtered global depolarization Dendrites integrate local synaptic inputs with this signal direction-selective manner. Coincidental outward direction generate suprathreshold transients. Moreover, metabotropic glutamate receptor 2 (mGluR2) signaling SACs modulates initiation transients dendrites but at soma. In contrast, voltage-gated potassium channel 3 (Kv3) dampens fast Together, complementary mGluR2 Kv3 different regions leads compartmentalization selectivity, highlighting importance these computation.

Язык: Английский

Dendritic mGluR2 and perisomatic Kv3 signaling regulate dendritic computation of mouse starburst amacrine cells DOI Creative Commons
Héctor Acarón Ledesma, Jennifer Ding, Swen Oosterboer

и другие.

Nature Communications, Год журнала: 2024, Номер 15(1)

Опубликована: Фев. 28, 2024

Abstract Dendritic mechanisms driving input-output transformation in starburst amacrine cells (SACs) are not fully understood. Here, we combine two-photon subcellular voltage and calcium imaging electrophysiological recording to determine the computational architecture of mouse SAC dendrites. We found that perisomatic region integrates motion signals over entire dendritic field, providing a low-pass-filtered global depolarization Dendrites integrate local synaptic inputs with this signal direction-selective manner. Coincidental outward direction generate suprathreshold transients. Moreover, metabotropic glutamate receptor 2 (mGluR2) signaling SACs modulates initiation transients dendrites but at soma. In contrast, voltage-gated potassium channel 3 (Kv3) dampens fast Together, complementary mGluR2 Kv3 different regions leads compartmentalization selectivity, highlighting importance these computation.

Язык: Английский

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