The emerging role of glucagon-like peptide 1 in binge eating DOI
Katherine N. Balantekin,

Martin J. Kretz,

Elizabeth G. Mietlicki‐Baase

и другие.

Journal of Endocrinology, Год журнала: 2024, Номер 262(1)

Опубликована: Апрель 17, 2024

Binge eating is a central component of two clinical disorders: binge disorder and bulimia nervosa. However, the large treatment gap highlights need to identify other strategies decrease eating. Novel pharmacotherapies may be one such approach. Glucagon-like peptide-1 (GLP-1) an intestinal brain-derived neuroendocrine signal with critical role in promoting glycemic control through its incretin effect. Additionally, energy balance effects GLP-1 are well-established; activation receptor (GLP-1R) reduces food intake body weight. Aligned these beneficial metabolic effects, there GLP-1R agonists that currently used for diabetes obesity. A growing literature suggests also play important Dysregulation endogenous system associated non-human animal models, promising approach suppress overconsumption occurs during Here, we briefly discuss normal reward then review emerging evidence suggesting disruptions signaling We consider potential utility GLP-1-based reducing behavior.

Язык: Английский

Obesity and cardiovascular disease: an ESC clinical consensus statement DOI Creative Commons
Konstantinos C. Koskinas, Emeline M. Van Craenenbroeck, Charalambos Antoniades

и другие.

European Heart Journal, Год журнала: 2024, Номер unknown

Опубликована: Авг. 30, 2024

The global prevalence of obesity has more than doubled over the past four decades, currently affecting a billion individuals. Beyond its recognition as high-risk condition that is causally linked to many chronic illnesses, been declared disease per se results in impaired quality life and reduced expectancy. Notably, two-thirds obesity-related excess mortality attributable cardiovascular disease. Despite increasingly appreciated link between broad range manifestations including atherosclerotic disease, heart failure, thromboembolic arrhythmias, sudden cardiac death, underrecognized sub-optimally addressed compared with other modifiable risk factors. In view major repercussions epidemic on public health, attention focused population-based personalized approaches prevent weight gain maintain healthy body from early childhood throughout adult life, well comprehensive loss interventions for persons established obesity. This clinical consensus statement by European Society Cardiology discusses current evidence epidemiology aetiology obesity; interplay obesity, factors conditions; management patients strategies lifestyle changes, interventional procedures, anti-obesity medications particular focus their impact cardiometabolic outcomes. document aims raise awareness factor provide guidance implementing evidence-based practices prevention optimal within context primary secondary prevention.

Язык: Английский

Процитировано

46
Type 2 diabetes mellitus in adults: pathogenesis, prevention and therapy DOI Creative Commons
Xi Lu,

Qingxing Xie,

Xiaohui Pan

и другие.

Signal Transduction and Targeted Therapy, Год журнала: 2024, Номер 9(1)

Опубликована: Окт. 2, 2024

Язык: Английский

Процитировано

39
Quantified Metrics of Gastric Emptying Delay by Glucagon-Like Peptide-1 Agonists: A Systematic Review and Meta-Analysis With Insights for Periprocedural Management DOI
Brent Hiramoto, Thomas R. McCarty, Nayna A. Lodhia

и другие.

The American Journal of Gastroenterology, Год журнала: 2024, Номер 119(6), С. 1126 - 1140

Опубликована: Апрель 18, 2024

INTRODUCTION: Divergent recommendations for periprocedural management of glucagon-like peptide-1 (GLP-1) receptor agonist (GLP-1 RA) medications rely on limited evidence. We performed a systematic review and meta-analysis to provide quantitative measures gastric emptying relevant mechanisms weight loss GLP-1 RA. hypothesized that the magnitude delay would be low clinical significance procedural sedation risks. METHODS: A protocolized search identified studies RA quantified measures. Pooled estimates using random effects were presented as weighted mean difference with 95% confidence intervals (CIs). Univariate meta-regression was assess influence type, short-acting vs long-acting mechanism action, duration treatment emptying. RESULTS: Fifteen met inclusion criteria. Five (n = 247) utilized scintigraphy. Mean T 1/2 138.4 minutes (95% CI 74.5–202.3) 95.0 54.9–135.0) placebo, pooled 36.0 17.0–55.0, P < 0.01, I 2 79.4%). Ten 411) acetaminophen absorption test, no significant in measured by max , area under curve (AUC) 4hr AUC 5hr ( > 0.05). On meta-regression, type RA, did not impact DISCUSSION: While ∼36 is quantifiable medications, it relative standard fasting periods. There substantial differences modalities reflective liquid (acetaminophen test), particularly at time points care.

Язык: Английский

Процитировано

26
Association of glucagon-like peptide-1 receptor agonists with risk of cancers-evidence from a drug target Mendelian randomization and clinical trials DOI Creative Commons
Yuming Sun, Yongjia Liu,

Yating Dian

и другие.

International Journal of Surgery, Год журнала: 2024, Номер unknown

Опубликована: Май 3, 2024

Glucagon-like peptide-1 receptor (GLP1R) agonists have been approved by Food and Drug Administration for management of obesity. However, the causal relationship GLP1R (GLP1RA) with cancers still unclear.

Язык: Английский

Процитировано

17
Obesity and cardiovascular disease: an ESC clinical consensus statement DOI Creative Commons
Konstantinos C. Koskinas, Emeline M. Van Craenenbroeck, Charalambos Antoniades

и другие.

European Journal of Preventive Cardiology, Год журнала: 2024, Номер unknown

Опубликована: Авг. 30, 2024

The global prevalence of obesity has more than doubled over the past four decades, currently affecting a billion individuals. Beyond its recognition as high-risk condition that is causally linked to many chronic illnesses, been declared disease per se results in impaired quality life and reduced expectancy. Notably, two-thirds obesity-related excess mortality attributable cardiovascular disease. Despite increasingly appreciated link between broad range manifestations including atherosclerotic disease, heart failure, thromboembolic arrhythmias, sudden cardiac death, underrecognized sub-optimally addressed compared with other modifiable risk factors. In view major repercussions epidemic on public health, attention focused population-based personalized approaches prevent weight gain maintain healthy body from early childhood throughout adult life, well comprehensive loss interventions for persons established obesity. This clinical consensus statement by European Society Cardiology discusses current evidence epidemiology aetiology obesity; interplay obesity, factors conditions; management patients strategies lifestyle changes, interventional procedures, anti-obesity medications particular focus their impact cardiometabolic outcomes. document aims raise awareness factor provide guidance implementing evidence-based practices prevention optimal within context primary secondary prevention.

Язык: Английский

Процитировано

16
Evaluating the causal effect of using glucagon-like peptide-1 receptor agonists on the risk of autoimmune diseases DOI
Yuming Sun, Qian Zhou,

Lorraine Edna Onzere

и другие.

Diabetes & Metabolic Syndrome Clinical Research & Reviews, Год журнала: 2025, Номер 19(1), С. 103186 - 103186

Опубликована: Янв. 1, 2025

Язык: Английский

Процитировано

3
Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD) in Children with Obesity: An Obesity Medicine Association (OMA) and Expert Joint Perspective 2025 DOI Creative Commons

Jennifer Panganiban,

Mohit Kehar, Samar H. Ibrahim

и другие.

Obesity Pillars, Год журнала: 2025, Номер 14, С. 100164 - 100164

Опубликована: Фев. 1, 2025

This Obesity Medicine Association (OMA) Expert Joint Perspective examines steatotic liver disease (SLD), which is composed of metabolic dysfunction-associated (MASLD), and steatohepatitis (MASH) in children with obesity. The prevalence obesity increasing, rates have tripled since 1963 from 5 % to now 19 US affected 2018. MASLD, the most common seen children, can be a precursor development Type 2 Diabetes (T2DM) primary reason for transplant listing young adults. We must vigilant prevention treatment MASLD childhood prevent further progression. joint clinical perspective based upon scientific evidence, peer expertise. medical literature was reviewed via PubMed search appropriate articles were included this review. work formulated collaboration eight hepatologists/gastroenterologists expertise two physicians OMA. authors who are experts field, determined sentinel questions often asked by clinicians regarding They created consensus guideline on screening, diagnosis, associated children. comorbidity increasing problem that needs addressed urgently. It well known chronic continue these diseases as adults, leads reduced life expectancy, quality life, healthcare financial burden. paper recommend healthy weight reduction not only through lifestyle modification but pharmacotherapy bariatric surgery. Therefore, guidance reviews available therapies achieve reverse progressive fibrosis, disease.

Язык: Английский

Процитировано

2
Skeletal interoception in osteoarthritis DOI Creative Commons
Dinglong Yang,

Jiawen Xu,

Ke Xu

и другие.

Bone Research, Год журнала: 2024, Номер 12(1)

Опубликована: Апрель 1, 2024

Abstract The interoception maintains proper physiological conditions and metabolic homeostasis by releasing regulatory signals after perceving changes in the internal state of organism. Among its various forms, skeletal specifically regulates bones. Osteoarthritis (OA) is a complex joint disorder involving cartilage, subchondral bone, synovium. bone undergoes continuous remodeling to adapt dynamic loads. Recent findings highlight that mediated aberrant mechanical loads contributes pathological resulting sclerosis OA. also potential mechanism for chronic synovial inflammation In this review, we offer general overview interoception, microenviroment remedeling. We discuss role abnormal OA, as well prospects challenges exploring novel OA therapies target interoception.

Язык: Английский

Процитировано

12
Role of NLRP3 inflammasome in central nervous system diseases DOI Creative Commons
Lu Zhang, Yufen Tang, Peng Huang

и другие.

Cell & Bioscience, Год журнала: 2024, Номер 14(1)

Опубликована: Июнь 7, 2024

Abstract The central nervous system (CNS) is the most delicate in human body, with complex structure and function. It vulnerable to trauma, infection, neurodegeneration autoimmune diseases, activates immune system. An appropriate inflammatory response contributes defence against invading microbes, whereas an excessive can aggravate tissue damage. NLRP3 inflammasome was first one studied brain. Once primed activated, it completes assembly of (sensor NLRP3, adaptor ASC, effector caspase-1), leading caspase-1 activation increased release downstream cytokines, as well pyroptosis. Cumulative studies have confirmed that plays important role regulating innate immunity its inhibitors shown good efficacy animal models various diseases. In this review, we will briefly discuss biological characteristics inflammasome, summarize recent advances clinical impact infectious, inflammatory, immune, degenerative, genetic, vascular diseases CNS, potential challenges a therapeutic target for CNS

Язык: Английский

Процитировано

12
Adiposity, type 2 diabetes and atherosclerotic cardiovascular disease risk: Use and abuse of the body mass index DOI Creative Commons
Benoît J. Arsenault, André C. Carpentier, Paul Poirier

и другие.

Atherosclerosis, Год журнала: 2024, Номер 394, С. 117546 - 117546

Опубликована: Апрель 14, 2024

The worldwide prevalence of individuals with an elevated body weight has increased steadily over the past five decades. Billions research dollars have been invested to improve our understanding causes and consequences having weight. All this knowledge has, however, failed influence populational trajectories most countries around world. Research on definition "obesity" also evolved. Body mass index (BMI), commonly used tool make its diagnosis, major limitations. In review article, we will highlight evidence from observational studies, genetic association studies randomized clinical trials that shown remarkable inter-individual differences in way humans store energy as fat. Increasing suggests that, opposed inclusive, lifestyle-based approaches, weight-centric approaches advising people simply eat less move more are not sustainable for long-term loss maintenance. It is time recognize outdated approach may produced harm than good. On basis pathophysiological, presented review, propose it be shift away traditional approach, which BMI-centric. Rather, emphasis should placed actionable lifestyle-related risk factors aiming at improving overall diet quality increasing physical activity level general population.

Язык: Английский

Процитировано

9