Instability of high polygenic risk classification and mitigation by integrative scoring

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Июль 24, 2024

Polygenic risk scores (PRS) continue to improve with novel methods and expanding genome-wide association studies. Healthcare commercial laboratories are increasingly deploying PRS reports patients, but it is unknown how the classification of high polygenic changes across individual PRS. Here, we assessed performance cataloged for three complex traits. We chronologically ordered all trait-related publications (Pub

Язык: Английский

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Low‐Density Lipoprotein Cholesterol, Cardiovascular Risk Factors, and Predicted Risk in Young Adults

Clinical Cardiology, Год журнала: 2024, Номер 47(9)

Опубликована: Сен. 1, 2024

ABSTRACT Background Young adults with elevated LDL‐C may experience increased burden of additional cardiovascular disease (CVD) risk factors. It is unclear how much levels, a modifiable factor, correlate non‐LDL‐C CVD factors among young or strongly these are associated long‐term predicted risk. We quantified clustering by to assess the association between and in adults. Methods The current analysis cross‐sectional study < 40 years an LDL‐C< 190 mg/dL participating National Health Nutrition Examination Survey (NHANES) January 2015 March 2020. measured prevalence Predicting Risk EVENTs (PREVENT) equations. Results Among 2108 adults, ≥ 130 was 15.5%. Compared 100 mg/dL, those 100–< 130, 130–< 160, 160–< had greater Both were independently 30‐year (OR 1.05, 95% CI 1.03–1.07 OR 1.17, 1.12–1.23, respectively). did not vary factor ( p interaction = 0.43). Conclusion Non‐LDL‐C cluster increasing levels Greater guidance on manage needed.

Язык: Английский

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PREVENT-Risikokalkulator der AHA: Weniger Verordnungen, aber mehr Infarkte möglich

Deutsches Ärzteblatt, Год журнала: 2024, Номер unknown

Опубликована: Сен. 11, 2024

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Polygenic Risk Scores for Coronary Heart Disease

JAMA, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 16, 2024

Sarah A. Abramowitz, BA; Kristin Boulier, MD; Karl Keat, BS; Katie M. Cardone, Manu Shivakumar, John DePaolo, MD, PhD; Renae Judy, MS; Francisca Bermudez, Nour Mimouni, Christopher Neylan, Dokyoon Kim, Daniel J. Rader, Marylyn D. Ritchie, Benjamin F. Voight, Bogdan Pasaniuc, Michael G. Levin, Scott Damrauer, Penn Medicine BioBank; J Rader; D Ritchie; JoEllen Weaver; Nawar Naseer; Giorgio Sirugo; Afiya Poindexter; Yi-An Ko; Kyle P. Nerz; Meghan Livingstone; Fred Vadivieso; Stephanie DerOhannessian; Teo Tran; Julia Stephanowski; Salma Santos; Ned Haubein; Joseph Dunn; Anurag Verma; Colleen Kripke; Marjorie Risman; Judy; Colin Wollack; Shefali S. M Damrauer; Yuki Bradford; Dudek; Theodore Drivas

Язык: Английский

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