Association between Chinese visceral adiposity index and cardiovascular events risk in individuals with cardiovascular–kidney–metabolic syndrome stage 0–3: a nationwide cohort study

International Urology and Nephrology, Год журнала: 2025, Номер unknown

Опубликована: Фев. 12, 2025

Язык: Английский

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Finerenone: A Pillar for the Treatment of Diabetic Kidney Disease

Опубликована: Март 1, 2025

Editorial Finerenone: A Pillar for the Treatment of Diabetic Kidney Disease Bharat Nathoo Division Nephrology, Mackenzie Health, Richmond Hill, L6C1R4, Ontario, Canada; [email protected] Received: 26 January 2025; Accepted: 28 Published: 1 March 2025 Abstract: kidney disease[DKD] has potential to progress end stage disease as well increase risk cardiovascular disease.. Remarkable advances have occurred in management DKD., This review highlights role finerenone a novel nonsteroidal minerallocorticoid receptor antagonist DKD.

Язык: Английский

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Breastfeeding and Future Cardiovascular, Kidney, and Metabolic Health—A Narrative Review

Nutrients, Год журнала: 2025, Номер 17(6), С. 995 - 995

Опубликована: Март 12, 2025

The benefits of breastfeeding for both mother and infant are generally recognized; however, the connections between breast milk, lactation, long-term offspring health disease remain incompletely understood. Cardiovascular–kidney–metabolic syndrome (CKMS) has become a major global public challenge. Insufficient milk supply, combined with various early-life environmental factors, markedly increases future risk CKMS, as highlighted by developmental origins (DOHaD) concept. Given its richness in nutrients bioactive components essential health, this review focuses on reprogramming strategies involving to improve offspring’s cardiovascular, kidney, metabolic health. It also highlights recent experimental advances understanding mechanisms driving CKMS programming. Cumulatively, evidence suggests that lactational impairment heightens development. In contrast, early interventions during lactation period focused animal models leverage response cues show potential improving outcomes—an area warranting further investigation clinical translation.

Язык: Английский

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Associations between dietary inflammatory index and cardiovascular kidney metabolic syndrome: insights from NHANES 2005–2018

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Март 20, 2025

Cardiovascular–kidney–metabolic syndrome (CKM) is recognized as a dynamic systemic disorder. Inflammation pivotal in CKM development. The dietary inflammatory index (DII) represents well-validated tool to quantify the overall potential of an individual diet. However, association between DII and remains undetermined. We analyzed data from 10,600 adults aged ≥ 20 years National Health Nutrition Examination Survey (NHANES 2005–2018). stages were classified on basis metabolic risk factors, cardiovascular disease (CVD), chronic kidney (CKD). Our findings indicated that advanced overlapped with high-DII profiles. derived four multivariable logistic regression analysis models revealed significant positive correlation continuous incidence syndrome. Additionally, quartiles demonstrated statistically increased fully adjusted (DII Q4 vs. Q1, odds ratio = 1.44, 95% confidence interval 1.08–1.92, P=0.014). results restricted cubic spline (RCS) suggested linear Subgroup analyses further sex-, depression-, sleep disorder-specific effects. This study indicates may be modifiable lever management, bridging patterns diseases.

Язык: Английский

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Correlation Between Metabolic Score for Visceral Fat and Cardiovascular-Kidney-Metabolic Syndrome: Analysis of NHANES 2011–2020

Healthcare, Год журнала: 2025, Номер 13(7), С. 694 - 694

Опубликована: Март 21, 2025

Background: Cardiovascular-kidney-metabolic (CKM) syndrome with high incidence and mortality rates is a prevalent health issue globally. The Metabolic Score for Visceral Fat (METS-VF), as new index valuating visceral adipose tissue, has been reported to be closely related variety of diseases. However, whether the METS-VF can an indicator predict risk CKM remains unclear. Methods: We selected National Health Nutrition Examination Survey (NHANES) database data from 2011-2020 year cycles conducted analyses between utilizing weighted Cox regression models, subgroup interaction analysis, restricted cubic spline (RCS) analysis. also used receiver operating characteristic (ROC) curves analyze compare diagnostic predictive ability METS-VF, BMI, other indicators assessing including VAI, fat mass, lean in syndrome. Results: In this study, average age was 34.40 ± 0.61 years non-CKM patients, while over 40.38 0.62 patients. Additionally, there greater proportion male patients (over 49.04%) comparison (37.94%). higher 6.63 0.02) compared (5.62 0.03). found had positive correlation hardly affected by confounding factors. more associated 20-59 female addition, better than body mass (BMI) indicators. Conclusions: potentially actionable that risk. may possible reference management

Язык: Английский

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Joint association of estimated glucose disposal rate and systemic inflammation response index with mortality in cardiovascular-kidney-metabolic syndrome stage 0–3: a nationwide prospective cohort study

Cardiovascular Diabetology, Год журнала: 2025, Номер 24(1)

Опубликована: Март 29, 2025

The Cardiovascular-Kidney-Metabolic (CKM) syndrome underscores the complex interactions among metabolic disorders, kidney disease, and cardiovascular conditions. Insulin resistance (IR) inflammation are crucial in CKM development, but their combined effect stages 0–3 remains unclear. Using data from National Health Nutrition Examination Survey (NHANES), we included 18,295 participants with 10 cycles between 1999 2018. IR was assessed using estimated glucose disposal rate (eGDR), systemic evaluated Systemic Inflammation Response Index (SIRI). primary endpoint all-cause mortality, secondary disease (CVD) mortality. Over an average follow-up period of 121 months, recorded 1,998 deaths 539 CVD deaths. Both eGDR SIRI were independent risk factors for hazard ratios (HR) 0.90 (0.86, 0.94) mortality 0.85 (0.78, 0.93) per unit increase eGDR. For SIRI, HRs 1.16 (1.11, 1.21) 1.33 (1.19, 1.46) SIRI. Compared to individuals high low levels, those levels exhibited significantly higher risks, 1.97 (1.58, 2.44) 2.35 (1.48, 3.73) Subgroup analysis revealed that impact particularly significant patients under 60 years old. In 0–3, have joint on Combining these markers can help identify high-risk early, enabling timely monitoring intervention improve outcomes. What is currently known about this topic? key research question? new? How might study influence clinical practice?

Язык: Английский

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Features of the Clinical Course of the Perioperative Period in Patients With Cardiovascular-Kidney-Metabolic Syndrome

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Introduction: Recently introduced concept of Cardiovascular-Kidney-Metabolic Syndrome (CVKMS) is defined as a health disorder associated with obesity, diabetes mellitus, chronic kidney disease, cardiovascular and aims to improve multidisciplinary approach the prevention, risk stratification, treatment these disorders. Aim: To substantiate feasibility for selection CVKMS within framework metabolic syndrome in anesthesiologic support extracardiac operations high-risk patients. Material methods: One hundred two patients were divided into group (n = 34) 68). The severity postoperative complications was classified according Clavien-Dindo definitions. length stay calculated. Results: Patients had significantly higher rate components: arterial hypertension, mellitus (p < 0.005 all comparisons). number 0.005). Clavien–Dindo grade II III 0.001 p 0.001; respectively). duration hospitalization longer 0.022). Conclusion: Compared syndrome, have incidence perioperative adverse events after surgery. This indicates expediency taking it account when providing anesthesia

Язык: Английский

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Racial and ethnic disparities in longitudinal trajectories of hospitalizations in patients diagnosed with heart failure

American Heart Journal, Год журнала: 2025, Номер unknown

Опубликована: Апрель 1, 2025

Язык: Английский

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Combination of Cardiovascular, Kidney, and Metabolic Diseases in a Syndrome Named Cardiovascular-Kidney-Metabolic, With New Risk Prediction Equations

Kidney International Reports, Год журнала: 2024, Номер 9(9), С. 2608 - 2618

Опубликована: Июнь 7, 2024

Associations of chronic kidney disease (CKD) with metabolic syndrome and cardiovascular (CVD) have long been recognized. Until recently, such associations were mainly limited to interrelationships between either heart kidney, syndrome, or kidney. It is the merit American Heart Association (AHA) set up a work group cardiologists, endocrinologists, nephrologists for purpose combining all 3 disorders in single entity, as an appreciation their pathophysiological interrelatedness. To this end, they proposed term cardiovascular-kidney-metabolic (CKM) which reflects multidirectional relationships among risk factors, CKD, system. Following consensus approach defining CKM 5 stages, subsequently developed new prediction equations, named predicting CVD events (PREVENT) included estimated glomerular filtration rate (eGFR) albuminuria variables addition traditional factors. Despite several limitations, development major step forward prediction. Its clinical application should translate into earlier, more appropriate treatment prevention syndrome.

Язык: Английский

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The Potential of Dietary Strategies: The Impact of Low-Carbohydrate Diet on Cardiovascular-Kidney-Metabolic Syndrome

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2025, Номер unknown

Опубликована: Янв. 3, 2025

Abstract This study aims to explore the prevalence of Low-carbohydrate diet (LCD) among individuals with cardiovascular-kidney-metabolic (CKM) syndrome and its relationship prognosis. Methods The included diagnosed CKM from National Health Nutrition Examination Survey (NHANES) database between 2009 2018. Participants were divided into two groups: those on a LCD not LCD. Multivariate logistic regression analysis was conducted assess factors influencing choice individuals. Kaplan-Meier survival curve multivariate Cox performed evaluate association risk all-cause mortality. Stratified consistency results. Results A total 866 non-CKM (stage 0) 26,989 (stages 1, 2, 3, 4) included. proportions for stages 0, 4 2.07%, 0.59%, 1.25%, 2.42%, 1.59%, respectively. indicated that age, gender, race, body mass index, diabetes status might influence revealed compared non-LCD individuals, had 61% reduced mortality (HR=0.39; 95% CI, 0.22-0.71, P=0.002). showed no interaction (P <0.05). Conclusion proportion in is relatively low. Furthermore, can reduce regardless stage.

Язык: Английский

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