American Association of Clinical Endocrinology Clinical Practice Guideline on Pharmacologic Management of Adults With Dyslipidemia

Endocrine Practice, Год журнала: 2025, Номер 31(2), С. 236 - 262

Опубликована: Фев. 1, 2025

Язык: Английский

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Statins for Primary Prevention of Cardiovascular Disease—With PREVENT, What’s a Clinician to Do?

JAMA, Год журнала: 2024, Номер 332(12), С. 961 - 961

Опубликована: Июль 29, 2024

This Viewpoint explores decision thresholds and the evidence that informs them as well how clinicians may respond to an updated risk estimation model, such Predicting Risk of cardiovascular disease EVENTs equations.

Язык: Английский

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Differences in Statin Eligibility with the Use of Predicting Risk of Cardiovascular Disease EVENTs Versus Pooled Cohort Equations in the UK Biobank

The American Journal of Cardiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 1, 2025

Язык: Английский

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Equations for Predicting the 10-Year Risk of Atherosclerotic Cardiovascular Disease in Population With Obesity

JACC Advances, Год журнала: 2025, Номер 4(2), С. 101542 - 101542

Опубликована: Янв. 15, 2025

Atherosclerotic cardiovascular disease (ASCVD) is a significant public health issue; however, current risk prediction models have limitations in populations with obesity. The aim of this study was to develop for predicting ASCVD patients Gender-specific equations predict were developed and validated using cohort 3,058 participants obesity (body mass index ≥30 kg/m2) the ARIC (Atherosclerosis Risk In Communities) 1,953 MESA (Multi-Ethnic Study Atherosclerosis). new called "ASCVD estimation Obesity-Specific Equations" or AROSE. We also conducted comparative analysis our algorithms against 2008 Framingham score (FRS) pooled (PCEs) both derivation validation cohorts. (ARIC), C-statistics 0.758 men 0.817 women, demonstrating good discrimination calibration (calibration chi-square = 1.71, P 0.634; χ2 women 0.77, 0.857). (MESA), AROSE outperformed PCEs FRS, 0.707 0.734 compared (0.706 men, 0.705 women) FRS (0.693 0.703 women). showed net reclassification improvements (P < 0.05) higher clinical benefit decision curve FRS. Our provided better 10-year individuals cohort, outperforming

Язык: Английский

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Risk Stratification for Cardiovascular Disease: A Comparative Analysis of Cluster Analysis and Traditional Prediction Models

European Journal of Preventive Cardiology, Год журнала: 2025, Номер unknown

Опубликована: Янв. 15, 2025

Abstract Aim Primary prevention of cardiovascular disease (CVD) relies on effective risk stratification to guide interventions. Current models, primarily developed using regression analysis, can lead inaccurate estimates when applied external populations. This study evaluates the utility cluster analysis as an alternative method for developing CVD comparing its performance with established prediction models. Methods Using data from 3,416 individuals (mean age 66 years and no prior CVD) followed average 5.2 incidence CVD, we a model based factors. We compared our Systematic Coronary Risk Evaluation (SCORE2), Pooled Cohort Equations (PCE) Predicting Cardiovascular Disease Events (PREVENT) used Poisson Cox compare between categories in each model. Predictive accuracy models was evaluated sensitivity, specificity, positive predictive value (PPV), negative (NPV), C-statistic. Results During study, 161 events were detected. The high-risk had sensitivity 59.0%, PPV 7.5% specificity 64.2% NPV 96.9% predict CVD. Compared groups SCORE2, PCE PREVENT, high NPV, but low PPV. No statistically significant differences found C-statistic Conclusions Cluster performed comparably existing identified larger group that included more who though false positives. Further studies larger, diverse cohorts are needed validate clinical stratification.

Язык: Английский

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Evaluation and Comparison of the PREVENT and Pooled Cohort Equations for 10‐Year Atherosclerotic Cardiovascular Risk Prediction

Journal of the American Heart Association, Год журнала: 2025, Номер unknown

Опубликована: Фев. 8, 2025

Background We compared the atherosclerotic cardiovascular disease (ASCVD) risk prediction performance of American Heart Association's Predicting Risk Cardiovascular Disease Events (PREVENT) Base and PREVENT Full equations (includes urine albumin/creatinine ratio, glycated hemoglobin, social deprivation index) with pooled cohort (PCEs). Methods included adults, aged 40 to 75 years, no history ASCVD, diabetes, or statin use in 2009 from Kaiser Permanente Southern California followed up through 2019. ASCVD was defined as myocardial infarction, fatal coronary heart disease, nonfatal ischemic stroke. model discrimination (Harrell C), mean calibration (estimated ratio predicted/observed event rates), curve among overall population stratified by sex race ethnicity. Results Of 559 241 adults (mean age, 54 years; 11% Asian, non‐Hispanic Black, 32% Hispanic), 10 695 developed an (median follow‐up, years). Harrell C 0.741 (95% CI, 0.736–0.745) for Base, 0.743 0.738–0.748) Full, 0.736–0.746) PCEs. Compared PCEs, both improved men but not women, Black other races ethnicities. Both were well calibrated calibration, 0.85–1.36; slope, 0.69–1.27), whereas PCEs overestimated 10‐year 1.80–2.18; 0.32–0.45). Conclusions better predict absolute across racial ethnic groups a contemporary US adult population.

Язык: Английский

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Fractured FRAX: Nurses’ role in reckoning with racism in international osteoporosis fracture risk calculations

Nursing Outlook, Год журнала: 2025, Номер 73(2), С. 102353 - 102353

Опубликована: Фев. 11, 2025

Язык: Английский

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Comprehensive Assessment of Biventricular and Biatrial Myocardial Strain Parameters at 4 Years Postpartum in a Cohort of Women with Previous Gestational Diabetes Mellitus

Journal of Clinical Medicine, Год журнала: 2025, Номер 14(4), С. 1271 - 1271

Опубликована: Фев. 14, 2025

Background/Objectives: No previous study has provided a comprehensive evaluation of all biventricular and biatrial myocardial strain parameters in women with gestational diabetes mellitus (pGDM). Accordingly, we aimed at investigating the structural deformation properties cardiac chambers cohort pGDM 4 years postpartum. Methods: A consecutive was compared to control group healthy uncomplicated pregnancy, matched by age, ethnicity week, Both groups underwent transthoracic echocardiography (TTE) implemented speckle-tracking (STE) subsequent carotid ultrasonography. The primary endpoint subclinical dysfunction, defined as left-ventricular (LV) global longitudinal (GLS) < 20%, whereas secondary early atherosclerosis, common artery (CCA) intima-media thickness (IMT) ≥ 0.7 mm. Results: total 32 (39.1 ± 6.5 yrs) 30 controls (40.8 5.0 were analyzed. Despite normal similar systolic function on conventional TTE, significantly lower than controls. Mean follow-up period 4.0 1.9 yrs. During follow-up, 62.5% developed 78.1% them diagnosed atherosclerosis. Third-trimester BMI (OR 1.88, 95% CI 1.19-2.98) third-trimester glycosylated hemoglobin (HbA1C) 2.34, 1.08-5.04) independently associated endpoint. HbA1C also predicted > 27 kg/m2 33 mmol/mol showed best sensitivity specificity for predicting both endpoints. Conclusions: Women history GDM complicated overweight/obesity uncontrolled have increased risk dysfunction atherosclerosis

Язык: Английский

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Evaluating the Reliability of Cardiovascular Risk Scales in Patients with Chronic Inflammatory Rheumatic Diseases

Seminars in Arthritis and Rheumatism, Год журнала: 2025, Номер 72, С. 152694 - 152694

Опубликована: Фев. 24, 2025

Язык: Английский

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Update in Outpatient General Internal Medicine: Practice-Changing Evidence Published in 2024

The American Journal of Medicine, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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