Importance
Glucagon-like
peptide
1
receptor
agonists
(GLP1R)
are
increasingly
being
used
for
the
treatment
of
obesity
in
adolescents.
It
is
currently
unknown
whether
GLP1R
associated
with
suicidal
ideation
or
attempts
this
population.
Objective
To
investigate
association
between
initiation
and
adolescents
obesity.
Design,
Setting,
Participants
Retrospective
propensity
score–matched
cohort
study
using
electronic
health
records
from
TriNetX
global
federated
network
December
2019
June
2024.
The
analysis
included
data
120
care
organizations,
mainly
USA.
were
aged
12
to
18
years
a
diagnosis
evidence
an
antiobesity
prescription
lifestyle
intervention
without
within
following
year.
Cohorts
balanced
baseline
demographic
characteristics,
psychiatric
medications
comorbidities,
diagnoses
socioeconomic
status
access
score
matching.
Exposure
Initial
(study
cohort)
(control
cohort).
Main
Outcomes
Measures
Incidence
based
on
International
Statistical
Classification
Diseases
Related
Health
Problems,
Tenth
Revision
codes
recorded
patient
during
months
follow-up.
Diagnoses
upper
respiratory
tract
infections
(URTI)
as
negative
control
outcomes,
gastrointestinal
symptoms
(GI)
positive
outcomes.
Results
A
total
4052
concomitant
identified
50
112
cohort.
Propensity
matching
resulted
3456
participants
each
Prescription
was
33%
reduced
risk
over
follow-up
(1.45%
vs
2.26%;
hazard
ratio
[HR],
0.67;
95%
CI,
0.47-0.95;
P
=
.02)
higher
rate
GI
(6.9%
5.4%;
HR,
1.41;
1.12-1.78;
.003)
but
no
difference
rates
URTI
diagnoses.
Conclusions
Relevance
In
study,
prescribed
had
lower
incidence
compared
matched
patients
not
who
treated
intervention.
These
results
suggest
favorable
safety
profile
detected
reduction
HRs
among
suggests
potential
avenues
future
research.
Psychiatry Research,
Год журнала:
2024,
Номер
333, С. 115763 - 115763
Опубликована: Фев. 2, 2024
The
study
examines
the
prevalence
of
12-month
suicidal
thoughts
and
lifetime
suicide
behaviors
among
young
adults
between
2000
2021.
Data
were
drawn
from
Health
Barometer
survey,
a
cross-sectional
survey
on
French
national
representative
sample.
2000,
2005,
2010,
2014,
2017,
2021
waves
pooled
to
examine
time
trends
in
respondents
aged
18
25
(n
=
13,326),
categorized
based
sex
their
occupational
status:
students,
those
employed,
who
are
neither
employment,
education
or
training
(NEETs).
ideation
(6.8
%)
is
no
different
that
(7.0
%),
despite
U-shape
curve
between.
In
contrast,
overall
attempts
was
significantly
higher
as
compared
what
observed
average
previous
21
years.
multivariate
models,
females
NEETs
at
greatest
risk
for
behaviors.
Additional
attention
prevention
efforts
needed
reach
training.
International Journal of Environmental Research and Public Health,
Год журнала:
2024,
Номер
21(7), С. 919 - 919
Опубликована: Июль 14, 2024
Mississippi
youth
are
demographically
unique
compared
to
those
of
the
nation.
The
aim
study
was
examine
drug
use
among
adolescents
in
that
US,
which
included
determining
prevalence
and
trends
as
well
drugs
on
school
property
estimating
differences
by
gender
race.
National
Youth
Risk
Behavior
Surveillance
System
(YRBSS)
data
from
2001
2021
were
obtained
for
analysis.
Summary
statistics,
ratio,
survey
Chi-squared
tests
independence
statistics
generated
comparison
all
students,
race
separately.
Trend
analysis
conducted
using
logistic
regression
combined
with
joinpoint
regression.
six
questions
being
studied
following:
have
you
ever
used
marijuana,
an
inhalant,
heroin,
methamphetamines,
or
injected
drugs,
offered,
sold,
given
illegal
during
last
12
months.
Survey
packages
R
account
complex
sampling
design
YRBSS
data.
On
national
level,
drug-related
risk
behaviors
showed
a
significant
decrease
2021.
In
Mississippi,
however,
only
"ever
marijuana"
trend,
while
three
remain
unchanged,
two
increased.
show
exhibited
significantly
higher
use,
more
likely
be
sold
property.
This
research
detailed
findings
use-related
issues
is
alarming.
poses
important
challenge
public
health
sounds
urgent
call
intervention
adolescents.
More
concerted
actions
at
community,
government
level
needed
reducing
controlling
traffic
Importance
Glucagon-like
peptide
1
receptor
agonists
(GLP1R)
are
increasingly
being
used
for
the
treatment
of
obesity
in
adolescents.
It
is
currently
unknown
whether
GLP1R
associated
with
suicidal
ideation
or
attempts
this
population.
Objective
To
investigate
association
between
initiation
and
adolescents
obesity.
Design,
Setting,
Participants
Retrospective
propensity
score–matched
cohort
study
using
electronic
health
records
from
TriNetX
global
federated
network
December
2019
June
2024.
The
analysis
included
data
120
care
organizations,
mainly
USA.
were
aged
12
to
18
years
a
diagnosis
evidence
an
antiobesity
prescription
lifestyle
intervention
without
within
following
year.
Cohorts
balanced
baseline
demographic
characteristics,
psychiatric
medications
comorbidities,
diagnoses
socioeconomic
status
access
score
matching.
Exposure
Initial
(study
cohort)
(control
cohort).
Main
Outcomes
Measures
Incidence
based
on
International
Statistical
Classification
Diseases
Related
Health
Problems,
Tenth
Revision
codes
recorded
patient
during
months
follow-up.
Diagnoses
upper
respiratory
tract
infections
(URTI)
as
negative
control
outcomes,
gastrointestinal
symptoms
(GI)
positive
outcomes.
Results
A
total
4052
concomitant
identified
50
112
cohort.
Propensity
matching
resulted
3456
participants
each
Prescription
was
33%
reduced
risk
over
follow-up
(1.45%
vs
2.26%;
hazard
ratio
[HR],
0.67;
95%
CI,
0.47-0.95;
P
=
.02)
higher
rate
GI
(6.9%
5.4%;
HR,
1.41;
1.12-1.78;
.003)
but
no
difference
rates
URTI
diagnoses.
Conclusions
Relevance
In
study,
prescribed
had
lower
incidence
compared
matched
patients
not
who
treated
intervention.
These
results
suggest
favorable
safety
profile
detected
reduction
HRs
among
suggests
potential
avenues
future
research.
