Cardiovascular risk emerges earlier by birth weight and preterm birth status in the United States add health sample

International Journal of Cardiology, Год журнала: 2025, Номер unknown, С. 132994 - 132994

Опубликована: Янв. 1, 2025

Язык: Английский

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Long-term expiratory airflow of infants born moderate-late preterm: A systematic review and meta-analysis

EClinicalMedicine, Год журнала: 2022, Номер 52, С. 101597 - 101597

Опубликована: Июль 30, 2022

Summary

Background

Moderate-late preterm (MLP; 32 to <37 weeks' gestation) birth is associated with reduced expiratory airflow during child, adolescent and adult years. However, some studies have reported only minimal limitation hence it unclear if clinical assessment in later life warranted. Our aim was compare maximal children adults born MLP term-born controls, expected norms.

Methods

We systematically reviewed reporting z-scores for spirometric indices (forced expired volume 1 second [FEV₁], forced vital capacity [FVC], FEV₁/FVC ratio flow at 25-75% of FVC [FEF_25-75%]) from participants aged five years or older, without a control group 4 databases (MEDLINE, CINAHL, Embase, Emcare). Publications were searched between the 22^nd September 2021 29^th 2021. A meta-analysis eligible conducted using random effects model. The study protocol published PROSPERO (CRD #42021281518).

Findings

screened 4970 articles identified 18 relevant studies, 15 which (8 controls 7 without). Compared had lower (mean difference [95% confidence interval] I²) FEV₁: -0.22 [-0.35, -0.09] 49.3%, FVC: -0.23 [-0.4, -0.06] 71.8%, FEV₁/FVC: -0.11 [-0.20 -0.03] 9.3% FEF_25-75%: -0.27 [-0.41 -0.12] 21.9%. Participants also z-scores, on average, when compared z-score 0 CI] -0.26 [-0.40 -0.11] 85.2%, -0.18 [-0.34 -0.02] 88.3%, -0.24 [-0.43 -0.05] 90.5% -0.33 [-0.54 -0.20] 94.7%.

Interpretation

Those worse airflows than those term, norms, although reductions modest. Clinicians should be aware that may higher risk obstructive lung disease peers.

Funding

This work supported by grants National Health Medical Research Council (Centre Excellence #1153176, Project grant #1161304); Future Fund (Career Development Fellowship J.L.Y Cheong #1141354) Victorian Government's Operational Infrastructure Support Programme. C. Du Berry's PhD candidature Melbourne Scholarship Centre Newborn Medicine.

Язык: Английский

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Unravelling the respiratory health path across the lifespan for survivors of preterm birth

The Lancet Respiratory Medicine, Год журнала: 2023, Номер 12(2), С. 167 - 180

Опубликована: Ноя. 14, 2023

Язык: Английский

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Preterm Birth, Family Income, and Intergenerational Income Mobility

JAMA Network Open, Год журнала: 2024, Номер 7(6), С. e2415921 - e2415921

Опубликована: Июнь 10, 2024

Importance Preterm birth (PTB) has been associated with lower income in adulthood, but associations intergenerational mobility and the role of family socioeconomic status (SES) as modifying factor are unclear. Objectives To assess whether association between PTB differs according to SES at mobility. Design, Setting, Participants This study comprised a matched cohort live births Canada January 1, 1990, December 31, 1996, follow-up until 2018. Statistical analysis was performed May 2023 March 2024. Exposure birth, defined 24 37 weeks’ gestational age (with subcategories 34-36, 32-33, 28-31, 24-27 weeks) vs early full term (gestational age, 37-41 weeks). Main Outcomes Measures Associations annual adulthood 2018 Canadian dollars were assessed overall (current exhange rate: $1 = CAD $1.37) stratified by quintiles, using generalized estimating equation regression models. percentile rank change (ie, difference individuals their parents distribution within respective generations) upward or downward (based on quintile) linear multinomial logistic regressions, respectively. Results Of 1.6 million included (51.1% boys 48.9% girls), 6.9% infants born preterm (5.4% 34-36 weeks, 0.7% 32-33 0.5% 28-31 0.2% After matching baseline characteristics (eg, sex, province parental demographics) adjusting for period effects, (mean difference, −$687 [95% CI, −$788 −$586]; 3% per year), differences greater among those belonging families lowest quintile −$807 −$998 −$617]; 5% year). also higher mobility, particularly earlier than 31 (24-27 weeks: mean change, −8.7 points −10.5 −6.8 points]). Conclusions Relevance In this population-based study, income, social economically disadvantaged families. Interventions optimize outcomes preterm-born would need define target population considering SES.

Язык: Английский

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Cardiovascular Morbidities in Adults Born Preterm: Getting to the Heart of the Matter!

Children, Год журнала: 2022, Номер 9(12), С. 1843 - 1843

Опубликована: Ноя. 28, 2022

Advances in perinatal and neonatal care have led to improved survival of preterm infants into adulthood. However, the shift focus long-term health adults born requires a clear understanding impact prematurity on developing organ systems development adult-oriented disease. A less well-recognized area risk for surviving is their cardiometabolic health. Epidemiologic evidence has linked birth systemic hypertension, type 2 diabetes, metabolic syndrome, heart failure, ischemic Of more significant concern that disorders higher compared full-term infants. The interconnected nature cardio-pulmonary system means worsening morbidity mortality preterm. Addressing problems holistically would help promote cardiovascular health, wellness, quality life over lifetime. Recognizing are unique subset population challenge current healthcare environment. issues relevant clinically research domain, using technology characterize cardiopulmonary physiology exercise tolerance, screening tools early diagnosis treatment, robust follow-up these with access longitudinal data improve both longevity

Язык: Английский

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Deciphering the tripartite interaction of urbanized environment, gut microbiome and cardio-metabolic disease

Journal of Environmental Management, Год журнала: 2025, Номер 377, С. 124693 - 124693

Опубликована: Фев. 28, 2025

Язык: Английский

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Long-term health outcomes of preterm birth: a narrative review

Frontiers in Pediatrics, Год журнала: 2025, Номер 13

Опубликована: Апрель 23, 2025

Despite a significant reduction in neonatal mortality due to advances care, preterm birth (PTB) continues pose challenge the escalating incidence of long-term complications, which refer health issues that persist or emerge beyond immediate period. The impact PTB, particularly extremely infants born before 28 weeks gestational age, is not confined early years but extends across lifespan, influencing physical, cognitive, and social development, as well outcomes. These often from childhood into adulthood, span multiple systems create broad spectrum concerns. This comprehensive narrative review literature delves breadth well-characterized complications associated with including neurodevelopmental, respiratory, cardiovascular, renal, gastrointestinal, endocrine system disorders. By providing care providers holistic understanding potential following this aims summarize current underscore value monitoring strategies proactive evaluations population. Our objective foster clinical approach anticipates these enabling interventions better management at-risk infants.

Язык: Английский

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Sex-specific effect of maternal thyroid peroxidase antibody exposure during pregnancy on 5- to 6-year-old children’s cardiometabolic risk score: The Ma'anshan birth cohort (MABC) study

European Journal of Endocrinology, Год журнала: 2024, Номер 191(3), С. 323 - 333

Опубликована: Авг. 22, 2024

Abstract Objective To explore the association between maternal thyroid peroxidase antibody (TPOAb) exposure and 5- to 6-year-old children's cardiometabolic risk (CMR). Methods A total of 2129 mother–child pairs were recruited from Ma'anshan Birth Cohort (MABC) study. Serum TPOAb was retrospectively measured in pregnant women using an electrochemiluminescence immunoassay. CMR score evaluated by serum glycolipids, blood pressure, waist circumference for children aged 5-6 years. Growth mixture modelling used fit trajectories levels throughout pregnancy. Multiple linear regression models logistic statistical analyses. Results Two thousand one hundred twenty-nine (mean [SD] age, 26.6 [3.6] years) enrolled final Maternal first trimester increased overall CMR, glucose level, HOMA-IR, triglyceride boys’ girls’ level. also associated with lower high-density lipoprotein cholesterol (HDL-C) In second trimester, positively Compared low trajectory, high trajectory had developing (OR = 3.40; 95% CI, 1.30-8.90), hyperglycemia 5.20; 2.20-12.28), insulin-resistance (adjusted OR 2.12; 1.10-4.07), hypertriglyceridemia 2.55; 1.06-6.14). Conclusions The pregnancy is a critical period affect children, some sex specificity, mainly detriment boys.

Язык: Английский

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Formula with large, milk phospholipid-coated lipid droplets in late-moderate preterm infants: a double-blind RCT

Pediatric Research, Год журнала: 2024, Номер unknown

Опубликована: Сен. 18, 2024

Язык: Английский

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Late preterm birth and growth trajectories during childhood: a linked retrospective cohort study

BMC Pediatrics, Год журнала: 2023, Номер 23(1)

Опубликована: Сен. 8, 2023

Evidence suggests that accelerated postnatal growth in children is detrimental for adult cardiovascular health. It unclear whether born late preterm (34-36 weeks) compared to full term (≥ 39 weeks), have different trajectories. Our objective was evaluate the association between gestational age groups and trajectories of 2006-2014 followed 2021 Ontario, Canada.We conducted a retrospective cohort study from singleton births TARGet Kids! primary care network with repeated measures weight height/length birth 14 years, who were linked health administrative databases. Piecewise linear mixed models used model (kg/month) height (cm/month) knots at 3, 12, 84 months. Analyses based on chronological age.There 4423 included mean 11 per child. The last visit 5.9 years (Standard Deviation: 3.1). Generally, more preterm, lower value until early adolescence. Differences very/moderate evident 12 months age. Weight similar small differences 84-168 (mean difference (MD) -0.04 kg/month, 95% CI -0.06, -0.03). Children had faster gain 0-3 (MD 0.70 cm/month, 0.42, 0.97) 3-12 0.17 0.11, 0.22).Compared term, average slightly slower rate after 0-12 Follow-up needed determine if are associated long-term disease risk.

Язык: Английский

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