Use of Rapid Antigen Detection Tests Versus Viral Culture in De-isolation Decision-Making for Critically Ill Patients Infected with Omicron B.1.1.529 DOI Creative Commons
Abeer N. Alshukairi, Ashraf Dada, Yasser Aldabbagh

и другие.

Dr Sulaiman Al Habib Medical Journal, Год журнала: 2023, Номер 5(3), С. 93 - 99

Опубликована: Авг. 9, 2023

Abstract Background COVID-19 vaccination effectively decreased hospitalization and mortality during the surge of infections with SARS-CoV-2 Omicron variant. However, patients infected variant who did not receive a third vaccine booster often required critical care unit (CCU) admission. The CCU bed utilization posed worldwide burden. decision to stop isolation in CCUs is challenging, given variable viral shedding heterogeneous patient populations. Rapid antigen detection tests (RADTs) have been used communities determine patients’ infectiousness need for quarantine. use RADTs de-isolation had studied. Methods Serial RADTs, RT-PCR culturing were performed case series three critically ill variants. Results duration infectious was 13–46 days post symptom onset (PSO). Concordant negative results observed between cultures on D32 PSO 1; D13 D15 2; D46 D48 3. In addition, concordant positive found D35 2. Significant agreement RADT culture findings (kappa statistic = 1.0 p -value 0.014). Conclusion Given their high predictive value respect cultures, may be promising practical tool ending decreasing burden utilization. Future studies are necessary confirm our findings.

Язык: Английский

Characteristics of symptoms during athletes’ COVID-19 infection and return to training: A descriptive study DOI Creative Commons
Jinhao Wang, Lan Lin, Li Jiang

и другие.

Medicine, Год журнала: 2025, Номер 104(19), С. e42380 - e42380

Опубликована: Май 9, 2025

This study aims to analyze the symptom characteristics and changes in symptoms upon returning training among athletes infected with novel corona virus disease 2019 (COVID-19). The findings provide recommendations for medical support after infection. In-depth analysis was conducted on data from 221 who tested positive COVID-19 between December 2022 January 2023. were collected during a sports performance recovery test series, which included 3 questionnaires assessing occurrence subjective severity infection periods. After initial test, took approximately 7 days negative. main fever, dry cough, fatigue, rates exceeding or approaching 90% fatigue being higher than moderate severity. Upon training, predominant muscle soreness, excessive sleepiness, 50% all lower intensity moderate. With progression of cough sleepiness decreased, while soreness remained relatively stable but reduced intensity. Some less prevalent showed minimal changes. Athletes Omicron variant primarily exhibit typically turn negative days. respiratory subside quickly, persistent mainly consist fatigue. Less may become prolonged if they fail promptly.

Язык: Английский

Процитировано

0
Comparing SARS-CoV-2 testing positivity rates and COVID-19 impact among different isolation strategies: a rapid systematic review and a modelling study DOI Creative Commons
Ya Gao, Yunli Zhao, Xi Zhang

и другие.

EClinicalMedicine, Год журнала: 2023, Номер 61, С. 102058 - 102058

Опубликована: Июнь 22, 2023

The optimal isolation duration for patients with COVID-19 remains unclear. To support an update of World Health Organization (WHO)'s Living Clinical management guidelines (https://www.who.int/publications/i/item/WHO-2019-nCoV-clinical-2022.2), this rapid systematic review and modelling study addresses the effects different periods preventing onward transmission leading to hospitalisation death among secondary cases.We searched WHO database studies up Feb 27, 2023. We included clinical any design confirmed by PCR test or antigen addressing impact strategy on spread COVID-19. There were no restrictions publication language, status, age patients, severity COVID-19, variants SARS-COV-2, comorbidity location, co-interventions. performed random-effects meta-analyses summarise testing rates persistent positivity after infection. pre-specified subgroup analyses symptom status meta-regression proportion fully vaccinated patients. developed a model compare three strategies death. (1) 5-day isolation, release; (2) removal based negative test; (3) 10-day release. incorporates estimates rates, effective reproduction number, adherence, false rate, case fatality rates. assess varying adherence testing, we conducted some sensitivity analyses. used Grading Recommendations Assessment, Development Evaluation approach certainty evidence. protocol is registered PROSPERO (CRD42022348626).Fifteen including 4188 proved eligible. Asymptomatic (27.1%, 95% CI: 15.8%-40.0%) had significantly lower positive rate than symptomatic (68.1%, 40.6%-90.3%) day 5. was 21.5% (95% 0-64.1%; moderate certainty) 10. Our suggested that risk difference (RD) asymptomatic between in hospitalisations (23 more cases per 10,000 isolated, uncertainty interval (UI) 14 33 more) mortality (5 UI 1 9 very small (very low certainty). For potential 5- versus much greater (RD 186 113 276 more; 41 11 73 may be little removing death, but average period (mean -3 days) will shorter (moderate certainty).5 days 10 result amount negligible mortality; however, level concerning lead high evidence is, uncertain.This work done collaboration WHO.

Язык: Английский

Процитировано

4
Use of Rapid Antigen Tests to End Isolation in a University Setting: Observational Study DOI Creative Commons
Liliana Zigo,

Alyson Wilkinson,

Megan Landry

и другие.

JMIR Formative Research, Год журнала: 2023, Номер 7, С. e45003 - e45003

Опубликована: Март 28, 2023

COVID-19 isolation recommendations have evolved over the course of pandemic. Initially, US Centers for Disease Control and Prevention required 10 days after a positive test result. In December 2021, this was reduced to minimum 5 with symptom improvement, followed by mask wearing. As result, several institutions higher education, including George Washington University, persons testing either submit negative rapid antigen (RAT) resolution leave or maintain 10-day period in absence RAT presence continued symptoms. RATs are tools that can be used both shorten periods ensure remain if infectious.The purpose analysis is report on experience implementing policies, examine number via testing, determine factors predicted uploading RAT, positivity percentages illustrate utility using end isolation.In study, 880 individuals at university Washington, DC, uploaded 887 between February 21 April 14, 2022. Daily were calculated, multiple logistic regression analyses examined odds campus residential living status (ie, off campus), student employee designation, age, isolation.A total 76% (669/880) during study period. Overall, 38.6% (342/887) positive. Uploaded 45.6% (118/259) time day 5; 45.4% (55/121) 6; 47.1% (99/210) 7; 11.1% (7/63) beyond. Adjusted modeling indicated cases had increased (odds ratio [OR] 2.54, 95% CI 1.64-3.92), whereas primary affiliation (OR 0.29, 0.12-0.69) 0.45, 0.39-0.52) decreased RAT. Of 545 477 cleared prior their due lack symptoms timely submission, resulting 1547 lost productivity saved compared all being days.RATs beneficial, as they support decision release from when recovered people who may still infectious. Future policies should guided similar protocols research reduce spread minimize disruption individuals' lives.

Язык: Английский

Процитировано

2
Psychological changes in athletes infected with Omicron after return to training: fatigue, sleep, and mood DOI Creative Commons
Chenhao Tan, Jinhao Wang,

Guohuan Cao

и другие.

PeerJ, Год журнала: 2023, Номер 11, С. e15580 - e15580

Опубликована: Июнь 15, 2023

This study aims to analyze the changes of approximately 1 month in fatigue, sleep, and mood athletes after returning training following infection with COVID-19 Omicron strain provide recommendations for infection.

Язык: Английский

Процитировано

1
Probability Distribution of SARS-Cov-2 (COVID) Infectivity Following Onset of Symptoms: Analysis from First Principles DOI Open Access

Mark P. Silverman

Open Journal of Statistics, Год журнала: 2023, Номер 13(02), С. 233 - 263

Опубликована: Янв. 1, 2023

The phasing out of protective measures by governments and public health agencies, despite continued seriousness the coronavirus pandemic, leaves individuals who are concerned for their with two basic options over which they have control: 1) minimize risk infection being vaccinated wearing a face mask when appropriate, 2) transmission upon self-isolating. For latter to be effective, it is essential an accurate sense probability infectivity as function time following onset symptoms. Epidemiological considerations suggest that period follows lognormal distribution. This proposition tested empirically construction density cumulative distribution based on quantiles reported several independent investigations. A comprehensive examination prototypical ideal clinical study, general statistical principles (the Principle Maximum Entropy Central Limit Theorem) reveals random variable. Subsequent evolution new variants may change parameters distribution, can updated methods in this paper, but form expected remain most probable consistent mathematical requirements available information.

Язык: Английский

Процитировано

0
COVID-19: Bases biológicas de una pandemia DOI Creative Commons
José Luis Cabrera

Interciencia médica, Год журнала: 2023, Номер 13(2), С. 28 - 39

Опубликована: Июль 7, 2023

El SARS-CoV-2 es un virus respiratorio altamente infeccioso que surgió a fines del 2019 y se propagó rápidamente hasta convertirse en una pandemia con severas consecuencias principalmente sanitarias, económicas sociales. Sus características virológicas son complejas le han permitido adaptarse produciendo mutaciones aumentado la transmisión, producido escape inmunológico complicar el control de pandemia. En este artículo desarrollamos elimpacto las bases agente causal.

Процитировано

0
Use of Rapid Antigen Detection Tests Versus Viral Culture in De-isolation Decision-Making for Critically Ill Patients Infected with Omicron B.1.1.529 DOI Creative Commons
Abeer N. Alshukairi, Ashraf Dada, Yasser Aldabbagh

и другие.

Dr Sulaiman Al Habib Medical Journal, Год журнала: 2023, Номер 5(3), С. 93 - 99

Опубликована: Авг. 9, 2023

Abstract Background COVID-19 vaccination effectively decreased hospitalization and mortality during the surge of infections with SARS-CoV-2 Omicron variant. However, patients infected variant who did not receive a third vaccine booster often required critical care unit (CCU) admission. The CCU bed utilization posed worldwide burden. decision to stop isolation in CCUs is challenging, given variable viral shedding heterogeneous patient populations. Rapid antigen detection tests (RADTs) have been used communities determine patients’ infectiousness need for quarantine. use RADTs de-isolation had studied. Methods Serial RADTs, RT-PCR culturing were performed case series three critically ill variants. Results duration infectious was 13–46 days post symptom onset (PSO). Concordant negative results observed between cultures on D32 PSO 1; D13 D15 2; D46 D48 3. In addition, concordant positive found D35 2. Significant agreement RADT culture findings (kappa statistic = 1.0 p -value 0.014). Conclusion Given their high predictive value respect cultures, may be promising practical tool ending decreasing burden utilization. Future studies are necessary confirm our findings.

Язык: Английский

Процитировано

0