Effect of Esketamine-Based Opioid-Sparing Anesthesia Protocol on the Quality of Early Recovery After Urological Surgery: A Randomized Clinical Trial DOI Creative Commons
Yu Qi, W. Li,

Ying Ren

и другие.

Drug Design Development and Therapy, Год журнала: 2025, Номер Volume 19, С. 2005 - 2016

Опубликована: Март 1, 2025

The quality of postoperative recovery under enhanced after surgery protocols has always been the focus anesthesiologists. It proven that esketamine application during perioperative period can reduce use opioid drugs and improve recovery. present study explored effect esketamine-based opioid-sparing anesthesia protocol on in patients undergoing elective urological surgery. A randomized, double-blind, controlled clinical trial was adopted. Patients aged 18-65 years, with American Society Anesthesiologists physical status grades I-III, scheduled for laparoscopic partial nephrectomy or unilateral surgery, were randomly divided into OSA group control group. received 0.25 mg/kg induction operation, maintenance carried out at a rate 0.125 mg·kg⁻¹·h⁻¹. primary outcome measure Quality Recovery Scale-15 score 24 hours operation. total significantly higher than groups operation (114 [108, 116] vs 106 [102, 109], p < 0.001). level better post-anesthesia care unit, demonstrated by shorter eye-opening time (19 [17 20] 22 [18, 22], = 0.031) extubation (20 [20, 23] 25 25], 0.004). Additionally, incidence nausea vomiting within 0-48 lower groups. early recovery, accelerate rehabilitation

Язык: Английский

The antidepressant actions of ketamine and its enantiomers DOI
Jenessa N. Johnston, Ioline D. Henter, Carlos A. Zarate

и другие.

Pharmacology & Therapeutics, Год журнала: 2023, Номер 246, С. 108431 - 108431

Опубликована: Май 4, 2023

Язык: Английский

Процитировано

72
Efficacy and safety of perioperative application of esketamine on postpartum depression: A meta-analysis of randomized controlled studies DOI
Yazhou Wen, Mingjie Mao, Xian Wang

и другие.

Psychiatry Research, Год журнала: 2024, Номер 333, С. 115765 - 115765

Опубликована: Фев. 2, 2024

Язык: Английский

Процитировано

15
Ketamine and its two enantiomers in anesthesiology and psychiatry: A historical review and future directions DOI Creative Commons
Kenji Hashimoto, Mingming Zhao, Tingting Zhu

и другие.

Journal of Anesthesia and Translational Medicine, Год журнала: 2024, Номер 3(3), С. 65 - 75

Опубликована: Июль 11, 2024

Ketamine, a dissociative anesthetic, is widely utilized in both human and veterinary anesthesia. Its (S)-enantiomer, esketamine, similarly employed for anesthesia analgesia. The anesthetic effects of ketamine esketamine arise from their antagonism the N-methyl-D-aspartate receptor (NMDAR). In field psychiatry, rapid-acting antidepressant properties severe depression have generated significant interest, resulting its increased off-label usage United States (U.S.). 2019, nasal spray received approval use U.S. Europe. However, concerns emerged regarding potential adverse effects, including long-term efficacy, addiction risks, suicide risk clinical settings. contrast, arketamine, (R)-enantiomer ketamine, exhibits superior longer-lasting rodent models depression, with fewer side compared to esketamine. Nevertheless, research on efficacy safety arketamine patients remains limited. This article provides concise exploration historical two enantiomers while also delving into future directions application these fields.

Язык: Английский

Процитировано

11
Association between esketamine interventions and postpartum depression and analgesia following cesarean delivery: a systematic review and meta-analysis DOI

Shijin Ma,

Yuzhe Dou, Wei Wang

и другие.

American Journal of Obstetrics & Gynecology MFM, Год журнала: 2024, Номер 6(3), С. 101241 - 101241

Опубликована: Янв. 21, 2024

Язык: Английский

Процитировано

9
Efficacy and safety of esketamine for perioperative depression in patients undergoing elective surgery: A meta-analysis of randomized controlled trials DOI

Xue-jie Lou,

Di Qiu,

Zhuo-Yu Ren

и другие.

Asian Journal of Psychiatry, Год журнала: 2024, Номер 95, С. 103997 - 103997

Опубликована: Март 11, 2024

Язык: Английский

Процитировано

8
The effects of prophylactic use of esketamine on postoperative depression and quality of life: a meta-analysis DOI Creative Commons

G. Niu,

Xiaozhu ZHENG,

Bigao DENG

и другие.

Minerva Anestesiologica, Год журнала: 2024, Номер 90(4)

Опубликована: Март 18, 2024

INTRODUCTION: The aim of this systemic review and meta-analysis was to assess the impact prophylactic use esketamine on postoperative depression quality life in patients.EVIDENCE ACQUISITION: We searched for all articles patients after surgury electronic data bases, including PubMed, EMBASE, Cochrane Central Register Controlled Trials, Web Science, up June 2023.The included studies compared using placebo through randomized controlled trials. outcome measurements consist indicators that can reflect patients' post Risk Bias tool Review Manager 5.4 adopted risk bias.EVIDENCE SYNTHESIS: study a total 11 trials with 1447 participants. This demonstrated prophylacticuse alleviated depressive symptoms (standardized mean difference [SMD]: -0.61; 95% confidence interval [CI]: -0.96 -0.25; P=0.0008) incidence (relative [RR]:0.37;95% 0.22 0.62; P=0.0001), reducing occurrence depression, anxiety, chronic pain. Additionally, it improved sleep enhanced patients.CONCLUSIONS: Prophylactic during preoperative anesthesia period has shown significant benefits improving life. It effectively alleviate pain, as well enhance quality.

Язык: Английский

Процитировано

8
Perioperative esketamine combined with butorphanol versus butorphanol alone for pain management following video-assisted lobectomy: a randomized controlled trial DOI
Hongjian Wang, Zicheng Wang, Junbao Zhang

и другие.

International Journal of Clinical Pharmacy, Год журнала: 2025, Номер unknown

Опубликована: Янв. 3, 2025

Язык: Английский

Процитировано

1
Effects of remimazolam and propofol on sleep rhythm and delirium after spinal surgery in elderly patients DOI Creative Commons

Li Yaqiu,

Zhou Heng,

Wu Ruimin

и другие.

Perioperative Medicine, Год журнала: 2025, Номер 14(1)

Опубликована: Фев. 11, 2025

This study aims to investigate the effects of remimazolam on postoperative melatonin secretion, sleep rhythm, and delirium (POD) in elderly patients undergoing spinal surgery. We selected 120 scheduled for elective surgery (lumbar interbody fusion via a posterior approach) under general anaesthesia from November 2023 January 2024. They were divided into 2 groups according medication, group (R group) propofol (P group), with 60 each group. The R received an induction dose 0.2 ~ 0.3 mg/kg, followed by continuous infusion at 0.1–0.2 mg/kg/h maintenance. P 1.5 2.0 4–6 Melatonin cortisol concentrations measured 04:00 day days 1, 2, 3. Pittsburgh Sleep Quality Index (PSQI) resting visual analog scale (VAS) pain scores recorded before surgery, 1 as well prior discharge. Additionally, we documented extubation time, PACU stay duration, total effective button presses analgesia pump, instances supplemental analgesia, occurrence complications. Compared group, exhibited significantly shorter time duration < 0.05). On 04:00, higher, lower, PSQI reduced incidence POD disturbance (POSD) was also lower Furthermore, VAS compared There no statistically significant differences between two terms pump presses, rates, intraoperative hypotension, or incidences nausea, vomiting, dizziness, respiratory depression > use has minimal impact secretion rhythms patterns, may reduce alleviate disturbances.

Язык: Английский

Процитировано

1
Mini-dose esketamine–dexmedetomidine combination to supplement analgesia for patients after scoliosis correction surgery: a double-blind randomised trial DOI Creative Commons
Ying Zhang, Fan Cui, Jiahui Ma

и другие.

British Journal of Anaesthesia, Год журнала: 2023, Номер 131(2), С. 385 - 396

Опубликована: Июнь 10, 2023

Patients often experience severe pain after scoliosis correction surgery. Esketamine and dexmedetomidine each improves analgesia but can produce side-effects. We therefore tested the hypothesis that a mini-dose esketamine-dexmedetomidine combination safely analgesia.Two hundred male female adults having surgery were randomised to patient-controlled sufentanil (4 μg kg-1 in normal saline) with either combined supplement (esketamine 0.25 mg ml-1 1 ml-1) or placebo. The primary outcome was incidence of moderate-to-severe within 72 h, defined as numeric rating scale (NRS: 0=no 10=worst pain) score ≥4 at any seven time points. Amongst secondary outcomes, subjective sleep quality assessed an NRS (0=best sleep) for first five postoperative nights.There 199 subjects included intention-to-treat analysis. Mean infusion rates 5.5 h-1 esketamine 0.02 dexmedetomidine. lower (65.7% [65/99]) than placebo (86.0% [86/100]; relative risk 0.76; 95% confidence interval: 0.65-0.90; P=0.001). Subjects given had intensity rest points (median difference -1 point; P≤0.005), movement six P≤0.001), better 5 nights -2 points; P<0.001). Adverse events did not differ between groups.The improved surgery.NCT04791059.

Язык: Английский

Процитировано

21
Safety and efficacy of low-dose esketamine in laparoscopic cholecystectomy: a prospective, double-blind randomized controlled trial DOI Creative Commons

Lu Zhao,

Zhengyu Li,

Bi Jin

и другие.

BMC Anesthesiology, Год журнала: 2024, Номер 24(1)

Опубликована: Фев. 1, 2024

Abstract Background Esketamine, recognized for its analgesic, sedative, and anti-inflammatory qualities, is integral in multimodal analgesia. However, the potential opioid-sparing effects of intravenous esketamine, along with impact on inflammatory responses, cognitive function during laparoscopic surgery, remain unexplored. Methods In this study, 90 patients scheduled cholecystectomy were equally randomized into three groups: a normal saline control group (NS), low-dose esketamine (LS) high-dose (HS). Subsequently, we monitored several parameters: hemodynamics, levels stress intraoperative doses sufentanil, remifentanil, propofol, 24-hour postoperative sufentanil requirements. We also evaluated alterations function, perioperative indicators, adverse reactions among groups. Results Compared to their 5 minutes prior anesthesia (T 0 ) 30 post-operation 4 ), NS exhibited more significant decrease Mean Arterial Pressure (MAP) Heart Rate (HR) at various time intervals: after skin incision 1 post-incision 2 conclusion operation 3 compared LS HS groups( P < 0.05). Furthermore, greater increase adrenaline (AD), noradrenaline (NE), endothelin (ET), C-reactive protein (CRP), tumor necrosis factor-alpha (TNF-α), interleukin-6 (IL-6) T , so than other two 24 hours had significantly higher Montreal Cognitive Assessment (MoCA) scores those group( The groups required lower surgery ( 0.05), experienced shorter recovery times, incidences nausea, vomiting, respiratory depression Conclusion administration has been shown be safe, effective, dependable context gallbladder surgery. It capacity stabilize hemodynamic ameliorate both from hastens recovery. it fosters restoration function. Notably, when combined nalbuphine, exhibits effects, reducing outcomes. Trial registration trial registered China Clinical Trials Registry Registration Number: ChiCTR2300067596. Retrospectively (date registration: 12/01/2023).

Язык: Английский

Процитировано

6