Antibiotics,
Год журнала:
2024,
Номер
13(6), С. 513 - 513
Опубликована: Май 31, 2024
Background:
Infective
endocarditis
(IE)
management
is
challenging,
usually
requiring
multidisciplinary
collaboration
from
cardiologists,
infectious
disease
specialists,
interventional
and
cardiovascular
surgeons,
as
more
than
half
of
the
cases
will
require
surgical
procedures.
Therefore,
it
essential
for
all
healthcare
providers
involved
in
managing
IE
to
understand
disease’s
characteristics,
potential
complications,
treatment
options.
While
systemic
embolization
one
most
frequent
complications
IE,
coronary
localization
emboli
causing
acute
myocardial
infarction
(AMI)
less
common,
with
an
incidence
ranging
1%
10%
cases,
but
has
a
much
higher
rate
morbidity
mortality.
There
are
no
guidelines
this
type
AMI
IE.
Methods:
This
narrative
review
summarizes
current
knowledge
regarding
septic
patients
Additionally,
paper
highlights
diagnosis
challenges
such
particularly
due
lack
protocols
or
consensus
field.
Results:
Data
extracted
case
reports
indicate
that
often
occurs
within
first
two
weeks
disease.
The
aortic
valve
commonly
vegetation,
occluded
vessel
frequently
left
anterior
descending
artery.
Broad-spectrum
antibiotic
therapy
followed
by
targeted
infection
control
essential,
offers
promising
results
through
embolectomy,
concomitant
replacement
aspiration
thrombectomy,
without
subsequent
stent
insertion.
Thrombolytics
be
avoided
increased
risk
bleeding.
Conclusions:
All
these
aspects
should
constitute
future
lines
research,
allowing
integration
team
studies
on
larger
patient
cohorts
and,
subsequently,
creating
assessing
guiding
potentially
fatal
complication.
Infection Control and Hospital Epidemiology,
Год журнала:
2025,
Номер
unknown, С. 1 - 8
Опубликована: Янв. 27, 2025
Abstract
Objective:
We
aimed
to
determine
whether
benchmarking
antimicrobial
use
(AU)
resistance
(AR)
using
select
AU/AR
ratios
is
more
informative
than
AU
metrics
in
isolation.
Design:
retrospectively
measured
(antimicrobial
therapy
days
per
1,000
present)
and
(specific
corresponding
AR
event)
two
hospitals
during
2020
through
2022.
then
had
stewardship
committee
members
evaluate
each
value
indicate
they
believed
it
represented
potential
overuse,
appropriate
use,
or
underuse
of
the
antimicrobials,
could
not
provide
an
assessment.
Setting:
Two
acute-care
hospitals.
Patients:
Hospitalized
patients.
Results:
In
semi-annual
facility-wide
analyses,
echinocandins
a
median
ratio
658.5
fluconazole-resistant
Candida
event
Hospital
A,
IV
vancomycin
114.9
108.2
methicillin-resistant
Staphylococcus
aureus
A
B,
respectively,
linezolid
33.8
88.0
vancomycin-resistant
Enterococcus
respectively.
When
values
were
evaluated
by
committees,
respondents
able
assess
based
on
compared
values.
Based
ratios,
most
identified
overuse
B.
Conclusion:
Select
provided
personnel,
which
can
be
used
motivate
audits
administration
appropriateness.
Journal of Clinical Medicine,
Год журнала:
2025,
Номер
14(6), С. 2087 - 2087
Опубликована: Март 19, 2025
Infective
endocarditis
(IE)
is
a
relatively
rare
but
potentially
life-threatening
disease
characterized
by
substantial
mortality
and
long-term
sequelae
among
the
survivors.
In
recent
decades,
dramatic
change
in
profile
of
patients
diagnosed
with
IE
has
been
observed
primarily
developed
countries,
most
likely
due
to
an
aging
population
increase
invasive
medical
procedures.
Nowadays,
typical
patient
usually
older,
complex
comorbidities,
history
significant
for
cardiac
disease,
including
degenerative
heart
valve
prosthetic
valves,
or
cardiovascular
implantable
electronic
devices
(CIEDs).
Moreover,
as
risk
factors
change,
predisposing
them
more
healthcare-associated
IE,
microbiology
also
shifting;
there
are
growing
concerns
regarding
rise
incidence
caused
difficult-to-treat
resistance
(DTR)
bacteria
at-risk
frequent
healthcare
contact.
The
present
review
aims
explore
evolving
landscape
summarize
current
knowledge
on
novel
diagnostics
ensure
timely
diagnosis
outline
optimal
therapy
DTR
bacterial
IE.
Expert Review of Anti-infective Therapy,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 31, 2025
Bloodstream
infections
(BSIs)
caused
by
Staphylococcus
aureus
are
common
worldwide,
representing
one
of
the
most
relevant
issues
in
clinical
infectious
diseases
practice.
In
particular,
BSIs
methicillin-resistant
S.
(MRSA-BSI)
still
today
a
challenge
since
mortality
burden
remains
elevated
although
decades
research.
The
following
topics
regarding
MRSA-BSI
were
reviewed
and
discussed
resorting
to
best
available
evidence
retrieved
from
PubMed/MEDLINE
up
October
2024:
i)
epidemiology;
ii)
microbiology;
iii)
classification,
with
focus
on
complicated
not
forms;
iv)
structured
approach
patient;
v)
pharmacokinetics
pharmacodynamics
main
antimicrobial
options;
vi)
controversies
therapeutic
approach.
Despite
ongoing
efforts
better
stratify
manage
MRSA-BSI,
there
is
no
universally
accepted
classification
system
accurately
distinguishing
between
uncomplicated/low
risk
complicated/high
forms.
Biomarkers
such
as
interleukin(IL)-10
hold
promise
order
enable
more
precise
stratification,
premise
for
an
appropriate
treatment
plan.
There
theoretical
rationale
implementing
combination
therapy
including
beta-lactam
agent
upfront,
especially
patients
considered
at
higher
unfavorable
outcomes,
but
further
data
necessary,
same
applies
newer
adjuvants.
Novel
microbiological
techniques
may
help
guiding
duration.
Frontiers in Cardiovascular Medicine,
Год журнала:
2025,
Номер
12
Опубликована: Апрель 3, 2025
Neurocardiology
is
an
evolving
field
focusing
on
the
interplay
between
nervous
system
and
cardiovascular
that
can
be
used
to
describe
understand
many
pathologies.
Acute
ischemic
stroke
understood
through
this
framework
of
interconnected,
reciprocal
relationship
such
occurs
secondary
cardiac
pathology
(the
Heart-Brain
axis),
injury
various
neurological
disease
processes
Brain-Heart
axis).
The
timely
assessment,
diagnosis,
subsequent
management
cerebrovascular
diseases
essential
part
bettering
patient
outcomes
progression
medicine.
Artificial
intelligence
(AI)
machine
learning
(ML)
are
robust
areas
research
aid
diagnostic
accuracy
clinical
decision
making
better
manage
neurocardiology.
In
review,
we
identify
some
widely
utilized
upcoming
AI/ML
algorithms
for
most
common
sources
stroke,
strokes
undetermined
etiology,
stroke.
We
found
numerous
highly
accurate
efficient
products
that,
when
integrated,
provided
improved
efficacy
prediction,
identification,
prognosis,
within
sphere
focus
cryptogenic
strokes,
there
promising
elucidating
likely
underlying
causes
thus,
treatment
options
prevention.
While
still
require
a
larger
knowledge
base
or
manual
algorithmic
training,
in
neurocardiology
has
potential
provide
more
comprehensive
healthcare
treatment,
increase
access
equitable
healthcare,
improve
outcomes.
Our
review
shows
evident
interest
exciting
new
frontier
with
artificial
learning.
Journal of Pharmaceutical Health Care and Sciences,
Год журнала:
2025,
Номер
11(1)
Опубликована: Апрель 14, 2025
Abstract
Background
Despite
numerous
studies
on
safety,
acute
kidney
injury
(AKI)
caused
by
vancomycin
and/or
gentamicin
remains
a
persistent
medical
issue.
However,
it
unclear
whether
AUC
below
600
mg·h/L
in
combination
with
trough
level
at
least
2
µg/mL
are
reliable
indices
to
reduce
the
risk
of
AKI
patients
treated
concomitant
and
gentamicin.
Objective
The
aim
was
elucidate
pharmacokinetic
factors
associated
development
receiving
use
setting
therapeutic
drug
monitoring
(TDM).
Methods
A
retrospective
study
conducted
15
TDM.
were
classified
into
group
no-AKI
group.
Vancomycin
area
under
curve
(AUC),
levels,
duration
investigated.
Results
Six
(40%)
developed
during
period.
In
(
n
=
6),
significant
higher
[median
(range)
561
(543‒712)
compared
9),
380
(185‒600)
mg·h/L,
p
0.026)],
although
no
differences
treatment
found
between
two
groups.
Receiver
operating
characteristic
analysis
showed
that
best
cut-off
for
predicting
523
0.852,
sensitivity
1.000
specificity
0.778
0.025).
Conclusions
1–2
µg/mL,
530
−
is
risk.
