European Journal of Clinical Pharmacology,
Год журнала:
2024,
Номер
80(4), С. 603 - 612
Опубликована: Фев. 6, 2024
Abstract
Purpose
This
study
aims
to
identify
PIM
prevalence
in
older
adults
according
the
2019
Beers
criteria,
Screening
Tool
of
Older
Person’s
Prescriptions
version
2
(STOPP
v2)
and
Portuguese
EU(7)-PIM
list
also
analyze
concordance
between
these
criteria.
Methods
A
retrospective
was
conducted
among
1200
(≥
65
years
old),
users
primary
health
care.
Demographic,
clinical,
pharmacological
data
were
collected
concerning
period
April
2021
August
2022.
comparative
analysis
performed
three
identification
determined
Lin
correlation
coefficient.
Results
The
mean
age
76.3
(SD
7.7)
old
57.6%
females.
Our
findings
indicate
varying
rates
criteria
with
63.8%
(95%
CI
61.0–66.6%),
66.8%
64.1–69.5%),
50.1%
47.2–53.0%)
take
at
least
one
list,
2019,
STOPP
v2
respectively.
highest
observed
for
proton
pump
inhibitors
(30.1%,
95%
27.6–32.9)
alprazolam
(10.1%,
8.4–11.9%).
poor
(<
0.834).
coefficient
found
(0.833),
lowest
(0.735).
Conclusion
reveals
adults,
as
assessed
by
different
highlights
need
targeted
interventions
improved
prescribing
practices.
In
future,
studies
should
focus
on
occurrence
negative
outcomes
associated
consumption.
Frontiers in Pharmacology,
Год журнала:
2025,
Номер
16
Опубликована: Апрель 8, 2025
Introduction
Potential
inappropriate
medications
(PIMs)
and
potential
drug–drug
interactions
(pDDIs)
are
important
factors
leading
to
adverse
drug
reactions
(ADRs)
in
the
elderly.
This
study
aimed
evaluate
incidence
pattern
of
PIMs
pDDIs
elderly
based
on
a
real-world
pharmacovigilance
database
identify
variables
associated
with
them.
Methods
retrospective
evaluated
by
updated
Beers
criteria
Lexi-Interact
online,
respectively,
using
ADRs
reported
for
those
aged
≥65
years
submitted
between
2011
2023
from
tertiary
care
teaching
hospital.
Correlation
were
investigated
binary
multiple
logistic
regression
analyses.
Results
A
total
1,423
included
involved
2,238
prescribed
drugs;
54.11%
men,
23.47%
classified
as
serious.
The
most
commonly
implicated
pharmacological
group
was
antimicrobial
agents.
Aspirin
clopidogrel
emerged
drugs
causing
majority
ADRs.
detected
32.04%
all
ADR
reports.
diclofenac
common
active
pharmaceutical
ingredients
involved,
gastrointestinal
bleeding
primary
clinical
manifestation
severe
caused
or
PIM-related
risk
factors.
Age,
number
diagnosed
diseases
drugs,
severity
preventability,
hypertension,
coronary
heart
disease,
arthritis
independent
influencing
PIMs.
Among
498
reports
≥2
202
cases
(14.20%)
had
pDDIs.
Blood
hematopoietic
organ
cardiovascular
agents
categories.
frequent
combinations
classes
C,
D,
X
aspirin–clopidogrel,
aspirin–heparin,
potassium
chloride–promethazine,
respectively.
increased
through
pharmacodynamic
mechanisms.
diseases,
stroke,
diabetes,
along
PIM
use,
predictors
Conclusion
found
be
relatively
high
elderly,
especially
treatment
cerebrovascular
non-steroidal
anti-inflammatory
(NSAIDs),
relevant
have
been
identified.
Healthcare
institutions
should
reinforce
management
rational
use
mitigate
occurrence
pDDIs,
thereby
enhancing
medication
safety.
Revista Foco,
Год журнала:
2025,
Номер
18(4), С. e8207 - e8207
Опубликована: Апрель 9, 2025
Objetivo:
Identificar
as
principais
alterações
gastrointestinais
decorrentes
da
polifarmácia
em
idosos.
Introdução:
O
aumento
longevidade
e
a
alta
prevalência
de
doenças
crônicas
tornam
o
uso
múltiplos
medicamentos
uma
realidade
comum
nessa
população,
elevando
risco
eventos
adversos
como
dispepsia,
refluxo,
gastrite,
úlceras,
má
absorção
na
motilidade
intestinal.
Tais
condições
comprometem
qualidade
vida
reforçam
necessidade
um
manejo
clínico
cuidadoso.
Referencial
Teórico:
envelhecimento
torna
os
indivíduos
mais
suscetíveis
consumidores
frequentes
medicamentos,
que
aumenta
chances
interações
medicamentosas
hospitalizações.
Ferramentas
Critérios
Beers
STOPP/START
são
importantes
para
identificar
prescrições
inadequadas
promover
racional
medicamentos.
Métodos:
Essa
revisão
integrativa
seguiu
modelo
proposto
por
Souza
(2010),
com
busca
nas
bases
BVS,
SciELO
PubMed,
considerando
publicações
entre
2015
2025.
Após
aplicação
dos
critérios
inclusão
exclusão,
14
artigos
foram
analisados.
Resultados:
Foram
inicialmente
identificadas
1.323
publicações,
sendo
selecionadas.
Nos
quais
indicam
idosos
polifarmácia,
especialmente
utilizam
anti-hipertensivos,
metformina,
antidepressivos,
antitrombóticos
AINE’s,
apresentam
maior
incidência
distúrbios
gastrointestinais.
Discussão:
A
está
fortemente
associada
complicações
gastrointestinais,
principalmente
pacientes
hipertensão
diabetes,
reforçando
importância
do
acompanhamento
multiprofissional
periódica
das
prescrições.
Conclusão:
evidenciou
é
fator
relevante
idosos,
necessária
implementação
estratégias
prescrição
segura
minimizar
riscos
melhorar
vida.
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Апрель 17, 2025
Abstract
Objectives
Many
older
adults
living
in
Resident
Care
Homes
for
the
Elderly
(RCHEs)
are
at
risk
of
polypharmacy
and
use
potentially
inappropriate
medication
(PIM).
Few
studies
have
evaluated
prevalence
consequences
PIM
among
RCHEs.
The
objectives
this
study
(1)
to
evaluate
29
RCHEs
Hong
Kong,
(2)
investigate
association
between
hospitalization
population.
Methods
This
is
a
prospective,
observational,
cohort
which
utilized
final-administered
data
from
that
participated
management
program.
Data
on
medications
administered
all
residents
participating
were
extracted
SafeMed
Medication
Management
System
(SMMS®),
purpose-built
Information
Technology
supporting
entire
process
outcome
interest
12-month
period
(January
1
December
31,
2023),
was
obtained
by
comparing
with
2023
Beers
criteria.
Hospital
admissions
during
SMMS®.Multivariable
logistic
regression
conducted
hospital
admissions.
Results
We
included
6,346
(age
82.9
±
8.6
years;
female
61.9%).
average
number
current
6.8
7.4.
Over
half
(51.5%)
had
(≥
5
medications).
34.5%.
Among
PIMs,
65.1%,
25.5%
9.4%
used
1,
2
>
respectively.
Residents
PIMs
associated
higher
rates
(Odds
Ratio
[OR]
1.73,
95%
confidence
interval
[CI]
1.54
1.69),
after
adjusting
age,
sex
comorbidities.
significantly
(OR:
2.17,
CI:
1.82
2.59
vs
0).
Conclusions
observed
one-third
RCHEs,
an
increased
hospitalization.
Our
findings
highlighted
urgent
need
strategies
improve
clinicians’
awareness
their
adverse
impact,
implement
pharmacist-led
reviews
European Journal of Clinical Pharmacology,
Год журнала:
2024,
Номер
80(4), С. 603 - 612
Опубликована: Фев. 6, 2024
Abstract
Purpose
This
study
aims
to
identify
PIM
prevalence
in
older
adults
according
the
2019
Beers
criteria,
Screening
Tool
of
Older
Person’s
Prescriptions
version
2
(STOPP
v2)
and
Portuguese
EU(7)-PIM
list
also
analyze
concordance
between
these
criteria.
Methods
A
retrospective
was
conducted
among
1200
(≥
65
years
old),
users
primary
health
care.
Demographic,
clinical,
pharmacological
data
were
collected
concerning
period
April
2021
August
2022.
comparative
analysis
performed
three
identification
determined
Lin
correlation
coefficient.
Results
The
mean
age
76.3
(SD
7.7)
old
57.6%
females.
Our
findings
indicate
varying
rates
criteria
with
63.8%
(95%
CI
61.0–66.6%),
66.8%
64.1–69.5%),
50.1%
47.2–53.0%)
take
at
least
one
list,
2019,
STOPP
v2
respectively.
highest
observed
for
proton
pump
inhibitors
(30.1%,
95%
27.6–32.9)
alprazolam
(10.1%,
8.4–11.9%).
poor
(<
0.834).
coefficient
found
(0.833),
lowest
(0.735).
Conclusion
reveals
adults,
as
assessed
by
different
highlights
need
targeted
interventions
improved
prescribing
practices.
In
future,
studies
should
focus
on
occurrence
negative
outcomes
associated
consumption.
