Maternal vaccination against COVID-19 and neonatal outcomes during Omicron: INTERCOVID-2022 study
American Journal of Obstetrics and Gynecology,
Год журнала:
2024,
Номер
231(4), С. 460.e1 - 460.e17
Опубликована: Фев. 16, 2024
Язык: Английский
COVID‐19 in pregnancy
The Obstetrician & Gynaecologist,
Год журнала:
2025,
Номер
27(1), С. 43 - 56
Опубликована: Янв. 1, 2025
Key
content
COVID‐19
is
known
to
be
associated
with
significant
morbidity
for
pregnant
women
and
their
babies.
This
susceptibility
adverse
clinical
outcomes
may
the
unique
physiological
characteristics
of
host.
Public
health
measures
recommended
management
prevention
critical
in
pregnancy
lactation
evolved
during
2020
pandemic;
some
decisions
were
controversial.
We
highlight
lessons
learnt
considerations
future
pandemic
preparedness.
Learning
objectives
To
outline
pathology
pregnancy,
including
placental
involvement.
summarise
current
evidence‐based
signpost
resources
updates.
discuss
role
vaccines
reduce
mortality
existing
novel
SARS‐CoV‐2
viral
strains.
Ethical
issues
Sustained
international
collaborative
strategies
are
crucial
ensure
global
equity
access
treatment
communicable
diseases.
Язык: Английский
Newborns at risk of COVID-19, the story continues
Journal of Perinatal Medicine,
Год журнала:
2024,
Номер
52(6), С. 567 - 574
Опубликована: Май 14, 2024
After
more
than
4
years
of
the
SARS-CoV-2
pandemic,
a
great
deal
knowledge
on
how
this
virus
affects
pregnant
women,
fetus
and
newborn
has
accumulated.
Guidelines
for
mode
delivery,
cord
clamping,
skin
to
skin,
breastfeeding,
rooming-in
have
become
uniform
across
world.
Vaccination
considerably
improved
outcomes,
but
hesitancy
amongst
patients
emergence
variants
remain
challenged
positivity
during
pregnancy
continues
be
associated
with
an
increased
risk
maternal
complications,
premature
delivery
higher
neonatal
mortality
morbidity.
An
emerging
body
data
now
exists
effect
in
early
medical
education
obstetrics
pediatrics,
longer-term
developmental
outcomes.
In
article,
we
review
development
field
since
our
last
review.
Язык: Английский
COVID-19 vaccination before or during pregnancy results in high, sustained maternal neutralizing activity to SARS-CoV-2 wild-type and Delta/Omicron variants of concern, particularly following a booster dose or infection
International Journal of Infectious Diseases,
Год журнала:
2024,
Номер
146, С. 107121 - 107121
Опубликована: Май 31, 2024
Язык: Английский
Impact of Antenatal SARS-CoV-2 Exposure on SARS-CoV-2 Neutralization Potency
Vaccines,
Год журнала:
2024,
Номер
12(2), С. 164 - 164
Опубликована: Фев. 5, 2024
A
pregnancy
booster
dose
significantly
reduces
the
risk
and
severity
of
COVID-19,
it
is
widely
recommended.
prospective
cohort
study
was
conducted
to
compare
transplacental
passage
maternal
antibodies
from
vaccination
or
infection
during
three
trimesters
against
both
vaccine-targeted
Wuhan
strain
Omicron
SARS-CoV-2.
Maternal–infant
dyads
vaccinated
mothers
were
collected
between
6
June
2022
20
September
2022.
We
analyzed
38
maternal–infant
who
had
been
infected
with
COVID-19
37
without
any
previous
infection.
Pregnant
women
received
their
last
vaccine
in
third
trimester
exhibited
highest
anti-spike
protein
antibody
levels
neutralizing
potency
BA.2
variant
cord
plasma.
Both
second-
third-trimester
could
lead
a
higher
level
neutralization
strains.
negative
effect
on
transfer
ratio
SARS-CoV-2
antibodies.
second
encouraged
for
maximum
humoral
protection
infants.
Язык: Английский
Maternal Immunization with Adjuvanted Recombinant Receptor-Binding Domain Protein Provides Immune Protection against SARS-CoV-2 in Infant Monkeys
Vaccines,
Год журнала:
2024,
Номер
12(8), С. 929 - 929
Опубликована: Авг. 20, 2024
Maternal
vaccinations
administered
prior
to
conception
or
during
pregnancy
enhance
the
immune
protection
of
newborn
infants
against
many
pathogens.
A
feasibility
experiment
was
conducted
determine
if
monkeys
can
be
used
model
placental
transfer
maternal
antibody
SARS-CoV-2.
Six
adult
rhesus
were
immunized
with
adjuvanted
recombinant-protein
antigens
comprised
receptor-binding
domain
human
IgG1-Fc
fusion
proteins
(RBD-Fc)
containing
protein
sequences
from
ancestral-Wuhan
Gamma
variants.
The
female
mounted
robust
and
sustained
anti-SARS-CoV-2
responses.
Blood
samples
collected
their
after
delivery
verified
prenatal
high
levels
spike-specific
IgG,
which
positively
correlated
IgG
titers
at
term.
In
addition,
an
in
vitro
test
ACE2
neutralization
indicated
that
infants'
demonstrated
antigen
specificity,
reflecting
immunization
either
Wuhan
Gamma-variant
antigens.
All
sera
showed
stronger
ACE2-RBD
binding
inhibition
when
variants
assay
more
closely
resembled
vaccine
RBD
sequence
than
distantly
related
(i.e.,
Delta
Omicron).
Monkeys
are
a
valuable
animal
for
evaluating
new
vaccines
promote
infant
health.
Further,
findings
highlight
enduring
nature
safety
elicited
by
recombinant
RBD-Fc
vaccine.
Язык: Английский
Efficacy of vaccination during pregnancy in reducing the risk of SARS-CoV-2 infection in infants younger than 12 months. Puglia (Italy), 2021–23
Cesare De Virgilio Suglia,
Pasquale Stefanizzi,
Giusy Graziano
и другие.
Human Vaccines & Immunotherapeutics,
Год журнала:
2024,
Номер
20(1)
Опубликована: Сен. 17, 2024
This
retrospective
cohort
study
evaluated
the
effectiveness
of
maternal
vaccination
against
COVID-19
in
reducing
risk
SARS-CoV-2
infection
infants
younger
than
12
months.
The
study,
conducted
at
"Policlinico"
University
Hospital
Bari,
included
3346
newborns
and
their
mothers.
explored
degree
protection
offered
by
depending
on
timing,
type,
trimester
vaccination,
also
taking
into
account
mother's
history
infection.
We
compared
incidence
rate
between
children
vaccinated
unvaccinated
mothers;
values
were
10.2%
18.1%,
respectively,
difference
was
statistically
significant.
overall
vaccine
45%.
Further
analysis
revealed
increasing
efficacy
as
doses
administered
to
mother
increased
case
a
previous
Dual
immune
stimulation
(vaccination
natural
infection)
83%
effective
preventing
among
newborns.
multivariable
models
confirmed
protective
effect
with
all
types
vaccines
used.
infection's
an
interesting
temporal
trend,
time,
suggesting
possible
correlation
persistence
antibodies
or
gradual
weaning.
results
capacity
are
line
global
literature.
Strengths
include
sample
size,
robust
methodology,
multivariate
analyses.
Institutions
could
intensify
awareness
campaigns
encourage
both
pregnant
women
those
who
would
like
become
receive
vaccination.
Язык: Английский
How to Manage a Neonate Born from a SARS-CoV2-Positive Mother: A Narrative Review
Pathogens,
Год журнала:
2024,
Номер
13(11), С. 977 - 977
Опубликована: Ноя. 8, 2024
From
2020
to
today,
considerable
knowledge
on
SARS-CoV-2
has
been
collected,
even
pregnant
women
and
their
fetuses
newborns,
clinical
guidelines
have
written
implemented
worldwide.
Vaccination
considerably
improved
outcomes,
but
hesitancy
amongst
patients
the
emergence
of
variants
remain
challenging,
positivity
during
pregnancy
continues
be
associated
with
an
increased
risk
maternal
complications,
premature
delivery,
higher
neonatal
mortality
morbidity.
A
body
data
now
exists
effect
early
medical
education
in
obstetrics
pediatrics,
longer-term
developmental
outcomes.
This
review
aimed
present
important
findings
outcomes
health
recommendations
for
neonate
born
from
a
SARS-CoV-2-positive
mother
order
summarize
effective
preventive
healthcare
guidelines.
Язык: Английский