Depression and Accelerated Aging: The Eveningness Chronotype and Low Adherence to the Mediterranean Diet Are Associated with Depressive Symptoms in Older Subjects DOI Open Access
José V. Sorlí,

Edurne de la Cámara,

Rebeca Fernández-Carrión

и другие.

Nutrients, Год журнала: 2024, Номер 17(1), С. 104 - 104

Опубликована: Дек. 30, 2024

Background and objectives: Depression often results in premature aging, which increases the risk of other chronic diseases, but very few studies have analyzed association between epigenetic biomarkers aging depressive symptoms. Similarly, limited research has examined joint effects adherence to Mediterranean diet (MedDiet) chronotype on symptoms, accounting for sex differences. Therefore, these are objectives our investigation a population at high cardiovascular risk. Methods: We 465 older subjects (aged 55–75) with metabolic syndrome assessed symptoms by Beck Inventory (BDI-II). MedDiet was measured 17-item score, Morningness–Eveningness Questionnaire (MEQ). Blood DNA methylation analyzed, epigenomic age acceleration were determined. focused Dunedin Pace Aging Computed from Epigenome (DunedinPACE). fitted multivariable models interaction terms. Results: Prevalence depression statistically higher women (p < 0.001). strongly inversely associated whole 0.01), while MEQ score 0.05). In analysis, both remained BDI-II 0.05), showing additive effects. No observed. women, significantly faster (measured DunedinPACE biomarker). This significant even after adjustment chronotype. Conclusions: syndrome, eveningness greater could potentially counteract Women showed stronger associations, importantly, we reported first time this that accelerated aging.

Язык: Английский

Association between epigenetic age and type 2 diabetes mellitus or glycemic traits: A longitudinal twin study DOI Creative Commons
Ke Miao, Xuanming Hong,

Weihua Cao

и другие.

Aging Cell, Год журнала: 2024, Номер 23(7)

Опубликована: Апрель 25, 2024

Abstract Epigenetic clocks based on DNA methylation have been known as biomarkers of aging, including principal component (PC) representing the degree aging and DunedinPACE pace aging. Prior studies shown associations between epigenetic T2DM, but results vary by age metrics people. This study explored T2DM or glycemic traits, 1070 twins (535 twin pairs) from Chinese National Twin Registry. It also temporal relationships traits in 314 (157 who participated baseline follow‐up visits after a mean 4.6 years. data were used to calculate metrics, PCGrimAge acceleration (PCGrimAA), PCPhenoAge (PCPhenoAA), DunedinPACE, longitudinal change rate PCGrimAge/PCPhenoAge. Mixed‐effects cross‐lagged modelling assessed cross‐sectional respectively. In analysis, positive identified well PCPhenoAA fasting plasma glucose, which may be not confounded shared genetic factors. Cross‐lagged models revealed that (fasting HbA1c, TyG index) preceded increases, index PCGrimAA increases. Glycemic are positively associated with especially DunedinPACE. increases PCGrimAA. Lowering levels reduce PCGrimAA, thereby mitigating age‐related comorbidities.

Язык: Английский

Процитировано

7
Bildungsarmut und Gesundheit DOI
Katharina Rathmann

Springer eBooks, Год журнала: 2025, Номер unknown, С. 1 - 33

Опубликована: Янв. 1, 2025

Процитировано

0
Associations between shift work and biological age acceleration: A population-based study DOI
Jianing Wang, Wei Hu, Bao-Peng Liu

и другие.

GeroScience, Год журнала: 2025, Номер unknown

Опубликована: Март 1, 2025

Язык: Английский

Процитировано

0
Lifespan Fluidity and Its Biological Limitations in Socio‐Economic Health Differences DOI

Caleb E. Finch,

Marja Jylhä

Journal of the American Geriatrics Society, Год журнала: 2025, Номер unknown

Опубликована: Апрель 5, 2025

Язык: Английский

Процитировано

0
Causal relationship between neuroticism and frailty: A bidirectional Mendelian randomization study DOI
Qingyan Chen,

Da Gan,

Yingjuan Zhang

и другие.

Journal of Affective Disorders, Год журнала: 2024, Номер 360, С. 71 - 78

Опубликована: Май 22, 2024

Язык: Английский

Процитировано

2
Depression and Accelerated Aging: The Eveningness Chronotype and Low Adherence to the Mediterranean Diet Are Associated with Depressive Symptoms in Older Subjects DOI Open Access
José V. Sorlí,

Edurne de la Cámara,

Rebeca Fernández-Carrión

и другие.

Nutrients, Год журнала: 2024, Номер 17(1), С. 104 - 104

Опубликована: Дек. 30, 2024

Background and objectives: Depression often results in premature aging, which increases the risk of other chronic diseases, but very few studies have analyzed association between epigenetic biomarkers aging depressive symptoms. Similarly, limited research has examined joint effects adherence to Mediterranean diet (MedDiet) chronotype on symptoms, accounting for sex differences. Therefore, these are objectives our investigation a population at high cardiovascular risk. Methods: We 465 older subjects (aged 55–75) with metabolic syndrome assessed symptoms by Beck Inventory (BDI-II). MedDiet was measured 17-item score, Morningness–Eveningness Questionnaire (MEQ). Blood DNA methylation analyzed, epigenomic age acceleration were determined. focused Dunedin Pace Aging Computed from Epigenome (DunedinPACE). fitted multivariable models interaction terms. Results: Prevalence depression statistically higher women (p < 0.001). strongly inversely associated whole 0.01), while MEQ score 0.05). In analysis, both remained BDI-II 0.05), showing additive effects. No observed. women, significantly faster (measured DunedinPACE biomarker). This significant even after adjustment chronotype. Conclusions: syndrome, eveningness greater could potentially counteract Women showed stronger associations, importantly, we reported first time this that accelerated aging.

Язык: Английский

Процитировано

0