Potentially Inappropriate Medication Use in Primary Care in Switzerland
JAMA Network Open,
Год журнала:
2024,
Номер
7(6), С. e2417988 - e2417988
Опубликована: Июнь 21, 2024
Potentially
inappropriate
medication
(PIM)
exposes
patients
to
an
increased
risk
of
adverse
outcomes.
Many
lists
explicit
criteria
provide
guidance
on
identifying
PIM
and
recommend
alternative
prescribing,
but
the
complexity
available
limits
their
applicability
amount
data
prescribing.
Язык: Английский
Assessing the prevalence of anticholinergic and sedative medications to avoid in older adults from the French Health Data System
Journal of the American Geriatrics Society,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 3, 2025
Abstract
Background
In
older
people,
medications
with
anticholinergic
or
sedative
properties
are
associated
falls,
frailty,
and
functional
cognitive
impairment.
These
often
described
as
a
subset
of
potentially
inappropriate
(PIMs).
We
examined
the
prevalence
to
avoid
in
people
France
2023.
Methods
This
cross‐sectional
study
used
anonymized
data
from
large
electronic
healthcare
database,
French
National
Health
Data
System
(Système
des
Données
de
Santé,
SNDS).
All
aged
65
years
January
1,
2023,
December
31,
were
included
this
study.
Dispensations
identified
according
PIM
criteria
(2023
American
Geriatrics
Society
Beers
Criteria
REMEDI[e]S
tool).
The
was
assessed
for
population
by
age
(65–84
85
older)
living
place
(home
institutionalized
patients)
subgroups
terms
number
percentage
patients.
Results
16,938,152
patients
(55%
women).
Among
all
patients,
79.8%
between
84
20.2%
older.
Most
lived
at
home
(97.0%),
3.0%
institutionalized.
32.8%
among
32.3%
65–84
34.8%
32.1%
54.5%
most
commonly
dispensed
oxazepam
(5.27%),
alprazolam
zopiclone
(4.85%),
bromazepam
(4.23%),
metopimazine
(2.88%),
paroxetine
(2.70%),
nefopam
(2.57%),
hydroxyzine
(2.17%).
Conclusions
highlighted
that
still
frequently
prescribed
despite
development
regular
updating
criteria.
Future
studies
needed
assess
whether
has
led
worsened
outcomes
adults
who
utilized
these
medications,
new
initiatives
should
be
developed
further
promote
deprescribing
prescribers
pharmacists.
Язык: Английский
Association of potentially inappropriate medications with frailty and frailty components in community‐dwelling older women in Japan: The Otassha Study
Geriatrics and gerontology international/Geriatrics & gerontology international,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 21, 2025
Aim
The
use
of
potentially
inappropriate
medications
(PIMs)
in
older
adults
can
increase
the
risk
drug‐related
adverse
events.
We
aimed
to
examine
associations
between
PIMs,
frailty,
and
each
frailty
component
community‐dwelling
women.
Methods
This
cross‐sectional
study
included
participants
aged
≥65
years
from
a
prospective
cohort
Japanese
Frailty
was
classified
using
version
Fried's
Criteria,
comprising
five
components.
PIMs
were
identified
screening
tool
for
among
regular
prescription
collected
participants'
notebooks.
Multivariable
logistic
regression
models
adjusted
age
comorbidities
used
association
(0,
1,
2,
≥3),
component.
possible
interactions
groups
(65–74
≥75
years)
investigated.
Age‐stratified
analyses
also
performed.
Results
analyzed
530
women
(median
[interquartile
range],
71
[68,
75]
with
prevalence
5.5%.
Three
or
more
associated
weight
loss
(adjusted
odds
ratio
[95%
confidence
interval],
3.80
[1.23,
11.80],
2.53
[1.15,
5.39]).
In
age‐stratified
analyses,
≥3
(8.39
[1.79,
48.98])
years,
whereas
1
2
(4.52
[1.17,
19.08])
weakness
(3.13
[1.22,
7.78])
those
65–74
years.
Conclusions
Our
results
may
suggest
that
number
PIM
prescriptions
is
components
Longitudinal
studies
are
required
clarify
causality
frailty.
Geriatr
Gerontol
Int
2025;
••:
••–••
.
Язык: Английский
Polypharmacy, drug–drug interactions, and potentially inappropriate medications among older adults: a cross-sectional study in Northeast Ethiopia
Frontiers in Public Health,
Год журнала:
2025,
Номер
13
Опубликована: Апрель 17, 2025
Background
The
global
older
adult
population
is
expected
to
increase
from
524
million
in
2010
1.5
billion
by
2050,
mainly
developing
countries.
Age-related
diseases,
comorbidities,
and
polypharmacy
make
appropriate
prescribing
crucial.
This
study
aimed
assess
the
prevalence
of
polypharmacy,
drug–drug
interaction,
potentially
inappropriate
medication
use
its
factors
an
Ethiopian
hospital.
Methods
A
facility-based
cross-sectional
on
236
patients
aged
65
above
at
Dessie
Comprehensive
Specialized
Hospital
(Jan
2022–Apr
2023)
used
2023
Beers
Criteria
START/STOP
V.3
identify
medications.
Polypharmacy
potential
interactions
were
assessed
using
Micromedex®,
with
descriptive
statistics
binary
logistic
regression
performed
SPSS
version
26.
Result
Of
this
study,
94
(39.8,
95%
CI:
35.7–44.5%)
prescribed
least
one
per
STOPP/START
criteria,
81
(34.3%)
identified
STOPP
13
(5.5%)
START.
According
Criteria,
108
(45.7,
40.1–51.0%)
received
medication.
was
observed
80
(33.9,
29.1–38.5%),
111
(47.0%).
Being
female
(AOR:
2.93),
age
≥75
1.52),
3.20)
linked
Criteria.
Age
70–74
2.30)
3.10)
also
associated
criteria.
Conclusion
Polypharmacy,
interactions,
medications
are
common
among
patients,
age,
sex,
as
contributing
factors.
Future
studies
needed
health
economic
impacts
use.
Язык: Английский
Characteristics of drugs with oral frailty patients among community pharmacy visitors: a cross-sectional study
BMC Oral Health,
Год журнала:
2024,
Номер
24(1)
Опубликована: Дек. 19, 2024
With
the
rise
in
older
population,
it
has
become
important
to
understand
relationship
between
oral
frailty
and
drug
use
consider
appropriate
medical
interventions
for
persons.
To
clarify
among
frailty,
use,
other
patient
backgrounds
identify
relevant
factors
using
information
from
questionnaires
pharmacy
medication
history
records.
This
cross-sectional
study
involved
community-dwelling
adults.
Older
adults
aged
≥
65
years
who
visited
44
pharmacies
Tochigi
Prefecture,
Japan,
with
their
prescriptions
July
1
September
10,
2021,
were
able
complete
questionnaire
independently
eligible
study.
An
Frailty
Index-8
score
4
was
used
define
group,
while
a
of
0–3
non-oral
group.
A
multivariate
logistic
regression
analysis
conducted
as
dependent
variable
items
survey
independent
variables.
total
1,386
participants
included
this
study,
761
(54.9%)
had
frailty.
Multivariate
showed
that
number
natural
teeth
(fewer
than
20),
benzodiazepine
significantly
associated
(p
<
0.001,
p
=
0.037,
respectively).
Our
results
will
provide
evidence
community
pharmacists
education,
recommend
consultations
dental
care
providers,
assist
healthcare
coordination.
Язык: Английский
Incidence of Potentially Inappropriate Prescribing: Longitudinal Investigation of Outpatient EHR Prescriptions
Journal of the American Geriatrics Society,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 31, 2024
ABSTRACT
Importance
The
incidence
of
potentially
inappropriate
medication
(PIM)
prescribing
among
older
adults
is
not
as
well
studied
its
prevalence.
Estimates
factors
associated
with
PIM
incidence,
such
patient
age,
sex,
race‐ethnicity,
subsidy
support,
and
comorbidity,
are
also
limited.
Objective
To
estimate
the
in
adult
outpatients,
predictors
for
each
class,
a
large
outpatient
electronic
health
records
(EHR)
cohort.
Design
Retrospective
study
outpatients
encounters
leading
to
prescription
orders,
2015–2018,
excluding
prevalent
cases.
Setting
Outpatients
receiving
care
from
multi‐site
system
western
Pennsylvania.
Participants
342,405
patients,
contributing
893,754
person‐years
follow‐up.
Main
Outcomes
Measures
based
on
automated
coding
2019
Beers
criteria.
A
multivariable
Poisson
regression
model
was
estimated
assess
impact
(PACE/PACENET)
risk.
For
association
between
time
evaluated
using
proportional
hazard
models.
Results
rate
(IR)
1
or
more
193.5
per
1000
person‐years,
led
by
short‐
intermediate‐acting
benzodiazepines
(37.6),
first‐generation
antihistamines
(32.8),
skeletal
muscle
relaxants
(22.0).
15%
higher
white
patients
35%
lower
males.
High
comorbidity
(Charlson
score
≥
3)
59%
Participation
PACE/PACENET
program,
an
83%
increase
incidence.
Each
additional
year
age
1.2%
reduction
Conclusions
Relevance
This
establishes
benchmarks
identifies
important
disparities
risk,
which
vary
class.
Язык: Английский