Community Threat, Positive Parenting, and Accelerated Epigenetic Aging: Longitudinal Links from Childhood to Adolescence DOI Creative Commons

Georgette Metrailer,

Karina Tavares,

Mikayla Ver Pault

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 26, 2024

Early Life Adversity (ELA) has been linked to accelerated epigenetic aging. While positive parenting is hypothesized buffer the detrimental effects of ELA on child development, its role in mitigating age acceleration remains unclear. Data from 2,039 children (49.7% female) Future Families and Child Wellbeing Study (FFCWS) were included current study (46.7% Black, 26.5% Hispanic, 19% White non-Hispanic). Home community threat observed measured ages 3 9. Salivary was at 9 15. Positive reduces pace aging low, but not high, community-threat environments. Interventions across home environments may be necessary prevent ELA's biological embedding.

Язык: Английский

Common DNA sequence variation influences epigenetic aging in African populations DOI Creative Commons
Gillian Meeks, Brooke A. Scelza,

Hana M. Asnake

и другие.

bioRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Авг. 26, 2024

Abstract Aging is associated with genome-wide changes in DNA methylation humans, facilitating the development of epigenetic age prediction models. However, most these models have been trained primarily on European-ancestry individuals, and none account for impact quantitative trait loci (meQTL). To address gaps, we analyzed relationships between age, genotype, CpG 3 understudied populations: central African Baka (n = 35), southern ‡Khomani San 52), Himba 51). We find that published methods yield higher mean errors cohorts compared to unaccounted-for sequence variation may be a significant factor underlying this loss accuracy. leverage information about associations genotype develop an predictor minimally influenced by meQTL, show model remains accurate across broad range genetic backgrounds. Intriguingly, also older individuals those exhibiting relatively lower acceleration our tend carry more age-reducing variants, suggesting novel mechanism which heritable factors can influence longevity.

Язык: Английский

Процитировано

4
Childhood Adversity and Adolescent Epigenetic Age Acceleration: The Role of Adolescent Sleep Health DOI Creative Commons
Karissa DiMarzio, Darlynn M. Rojo‐Wissar, Evelyn M. Hernandez

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Сен. 3, 2024

We investigated how a dimension of early life adversity (ELA) capturing threat in the home relates to later epigenetic age acceleration adolescence through sleep (duration, efficiency, and timing), empirically test theoretical models suggesting importance as key mechanism linking ELA with poor health outcomes, expand limited literature on aging among youth.

Язык: Английский

Процитировано

0
Community Threat, Positive Parenting, and Accelerated Epigenetic Aging: Longitudinal Links from Childhood to Adolescence DOI Creative Commons

Georgette Metrailer,

Karina Tavares,

Mikayla Ver Pault

и другие.

medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown

Опубликована: Дек. 26, 2024

Early Life Adversity (ELA) has been linked to accelerated epigenetic aging. While positive parenting is hypothesized buffer the detrimental effects of ELA on child development, its role in mitigating age acceleration remains unclear. Data from 2,039 children (49.7% female) Future Families and Child Wellbeing Study (FFCWS) were included current study (46.7% Black, 26.5% Hispanic, 19% White non-Hispanic). Home community threat observed measured ages 3 9. Salivary was at 9 15. Positive reduces pace aging low, but not high, community-threat environments. Interventions across home environments may be necessary prevent ELA's biological embedding.

Язык: Английский

Процитировано

0