Bulletin of Problems Biology and Medicine, Год журнала: 2024, Номер 1(3), С. 36 - 36
Опубликована: Янв. 1, 2024
Язык: Английский
European Journal of Cancer Prevention, Год журнала: 2024, Номер 34(1), С. 24 - 39
Опубликована: Май 29, 2024
Physical activity (PA) has an established role in the promotion of health and fitness prevention disease. Expected overall benefits include reduction all-cause morbidity death, weight control, improved quality life, bone decreased falls elderly subjects, , deeper cognition, reduced risk depression, anxiety, sleeplessness. Currently, PA is a mainstay management cardiovascular diseases, metabolic syndrome, diabetes, health. Recently, perception its primary secondary prevention, interception, treatment cancer, however, also gaining importance. Regular walking, simplest type PA, associated with disease mortality, cancer increasing interest. Furthermore, improves life patients, attenuating side effects chemotherapy, decreasing sarcopenia, fitness, inhibiting recurrence progression some types. It promotes emotional psychological inducing positive changes. While mechanisms, effective levels useful amount practice are well cardiology, they yet to be fully determined oncology. Nevertheless, recommended reduce general population, it been introduced programs for second cancers. In perspective, will help as integrative therapy patients survivors. The number beneficial continuum highlighted this review.
Язык: Английский
Процитировано
9
AJP Cell Physiology, Год журнала: 2024, Номер 327(3), С. C587 - C598
Опубликована: Июль 9, 2024
Metabolic diseases, notably obesity and type 2 diabetes (T2D), have reached alarming proportions constitute a significant global health challenge, emphasizing the urgent need for effective preventive therapeutic strategies. In contrast, exercise training emerges as potent intervention, exerting numerous positive effects on metabolic through adaptations to tissues. Here, we reviewed major features of our current understanding with respect intricate interplay between diseases key tissues, including adipose tissue, skeletal muscle, liver, describing some main underlying mechanisms driving pathogenesis, well role combat treat disease.
Язык: Английский
Процитировано
4
Frontiers in Psychology, Год журнала: 2025, Номер 16
Опубликована: Янв. 28, 2025
Background Cognitive errors involve negatively biased or distorted thinking patterns that can hinder effective decision-making. When such a phenomenon occurs in the exercise domain, this is referred to as exercise-related cognitive error. Such are typically assessed via questionnaire, but validated instrument for application Chinese-speaking populations lacking. Thus, study aims validate Chinese version of Exercise-related Errors Questionnaire (E-CEQ-C) among emerging adults, self-report measure evaluate context-relevant information related exercise. Methods Following forward-backward translation E-CEQ ( N = 24 items), E-CEQ-C and Distortions (CD-Quest-C) gathering evidence criterion-related validity were administered sample adults 376, 29.0% male) through an online survey. After two-week interval, 105 out 376 participants attended re-test E-CEQ-C. Item analysis, confirmatory factor analysis (CFA), internal consistency, test–retest reliability, concurrent analyzed. Results The findings from CFA support 24-item informed six-factor structure (χ 2 699.038, RMSEA 0.073, CFI 0.919, TLI 0.904, SRMR 0.055). Cronbach’s α six dimensions all above 0.7. reliability coefficients each subscale total scale acceptable, ranging 0.60 0.81. In accordance with literature, we also observed positive associations between constructs CD-Quest-C, which provided Conclusion This showed psychometrically sound assess populations.
Язык: Английский
Процитировано
0
Annals of the Rheumatic Diseases, Год журнала: 2025, Номер unknown
Опубликована: Янв. 1, 2025
Walking offers numerous health benefits, yet its association with symptomatic knee osteoarthritis (SKOA) remains uncertain. The conflation of purposeful walking and unintentional could contribute to this uncertainty. Therefore, we aimed examine the between daily steps, total steps incident SKOA. We conducted a population-based cohort study using data from UK Biobank. Of participants who had valid accelerometer at baseline but no history SKOA (identified through primary care or hospitalisation records), 89,969 were included. Hazard ratios (HRs) for categories (cadence ≥60 steps/min), <60 estimated Cox proportional hazard model. dose-response relationship was assessed restricted cubic spline regression. During mean follow-up 6.85 (SD, 1.14) years, 2711 developed For HRs (95% CIs) 0.84 (0.76-0.92), 0.81 (0.71-0.90), 0.74 (0.64-0.85) those 4000 5999, 6000 7999, ≥8000 steps/d, respectively, compared <4000 steps/d. Restricted regression analysis revealed declining curve potential threshold near 8000 Conversely, more significantly associated higher No significant observed steps. More lower SKOA, suggesting that may promote musculoskeletal help inform future guidelines prevention.
Язык: Английский
Процитировано
0
Canadian Journal of Cardiology, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
American Journal of Preventive Medicine, Год журнала: 2025, Номер unknown
Опубликована: Фев. 1, 2025
Язык: Английский
Процитировано
0
Obesity Reviews, Год журнала: 2024, Номер 25(11)
Опубликована: Июль 29, 2024
Summary Obesity represents a major public health emergency worldwide, and its etiology is shaped by complex interplay of environmental genetic factors. Over the last decade, polygenic risk scores (PRS) have emerged as promising tool to quantify an individual's obesity. The field PRS in obesity genetics rapidly evolving, shedding new lights on mechanisms holding promise for contributing personalized prevention treatment. Challenges persist terms clinical integration, including need further validation large‐scale prospective cohorts, ethical considerations, implications disparities. In this review, we provide comprehensive overview studying obesity, spanning from methodological nuances applications challenges. We summarize latest developments generation refinement advances methodologies aggregating genome‐wide association study data improving predictive accuracy, discuss limitations that be overcome fully realize potential benefits both medicine health.
Язык: Английский
Процитировано
3
European Heart Journal, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 11, 2024
The increasing prevalence of diabetes, obesity, and their cardiometabolic sequelae present major global health challenges highlight shortfalls current approaches to the prevention treatment these conditions. Representing largest burden morbidity mortality, pathobiological processes underlying diseases are in principle preventable and, even when disease is manifest, sometimes reversable. Nevertheless, with clinical public strategies, goals widespread remission remain largely aspirational. Application precision medicine that reduce errors improve accuracy medical recommendations has potential accelerate progress towards goals. Precision must also maintain safety ideally be cost-effective, as well being compatible an individual's preferences, capabilities, needs. Initial was made context rare diseases, much focus on pharmacogenetic studies, owing cause often attributable highly penetrant single gene mutations. By contrast, most obesity type 2 diabetes heterogeneous aetiology presentation, underpinned by complex interactions between genetic non-genetic factors. heterogeneity conditions can leveraged for development therapies. Adequate characterization necessitates diversity synthesis across data types research methods, culminating trials real-world application approaches. This State-of-the-Art Review provides overview state science medicine, outlining a roadmap study designs maximise opportunities address implementation diabetes.
Язык: Английский
Процитировано
3
Опубликована: Май 13, 2024
Despite significant prevention efforts, the numbers of physically inactive individuals, chronic illnesses, exhaustion syndromes and sick leaves are increasing. A still unresolved problem with exercise promotion is low participation sedentary persons. This collective term covers heterogeneous subgroups. Their engagement movement campaigns resistance to change influenced by numerous factors. Our aim was analyse survey data on health, performance, lifestyle habits approachability physical activity obtained from Germany-wide ActIv survey. From 2,888 study participants aged 50-60 years, 668 persons were categorised into subgroups "never-athletes", "sports-dropouts", "always-athletes" "sports-beginners". Large group differences found for BMI, assessment quality life, health fitness, risk factors problems. 42.5% "never-athletes" 32.5% "sports-dropouts" did not state any barriers sport. There substantial disparities between non-athlete groups in terms their motivation exercise. In contrast, there comparatively minor "sports-beginners", whose fitness primary motivators analyses suggest that (i) negative performance trends cannot be compensated appeals voluntary programmes (ii) powerful incentive systems required.
Язык: Английский
Процитировано
1
medRxiv (Cold Spring Harbor Laboratory), Год журнала: 2024, Номер unknown
Опубликована: Июль 30, 2024
The transferability of polygenic scores across population groups is a major concern with respect to the equitable clinical implementation genomic medicine. Since genetic associations are identified relative mean, inevitably differences in disease or trait prevalence among social strata influence relationship between PGS and risk. Here we quantify magnitude PGS-by-Exposure (PGSxE) interactions for seven human diseases (coronary artery disease, type 2 diabetes, obesity thresholded body mass index waist-to-hip ratio, inflammatory bowel chronic kidney asthma) pairs 75 exposures White-British subset UK Biobank study (n=408,801). Across 24,198 PGSxE models, 746 (3.1%) were significant by two criteria, at least three-fold more than expected chance under each criterion. Predictive accuracy significantly improved high-risk including interaction terms effects as large those documented low ancestries. predominant mechanism PGS×E shown be amplification presence adverse such polyunsaturated fatty acids, mediators obesity, determinants ill health. We introduce notion proportion needed benefit (PNB) which cumulative number treat range show that typically this halved 70
Язык: Английский
Процитировано
1