Severity and Long-Term Mortality of COVID-19, Influenza, and Respiratory Syncytial Virus

JAMA Internal Medicine, Год журнала: 2025, Номер unknown

Опубликована: Янв. 27, 2025

Importance SARS-CoV-2, influenza, and respiratory syncytial virus (RSV) contribute to many hospitalizations deaths each year. Understanding relative disease severity can help inform vaccination guidance. Objective To compare of COVID-19, RSV among US veterans. Design, Setting, Participants This retrospective cohort study analyzed national Veterans Health Administration electronic health record data nonhospitalized veterans who underwent same-day testing for RSV, were diagnosed with a single infection between August 1, 2022, March 31, 2023, or 2024. Exposures Infection RSV. Main Outcomes Measures Following inverse probability weighting, the cumulative incidence risk differences (RDs) calculated primary outcomes 30-day hospitalization, intensive care unit admission, death, as well secondary outcome long-term death extending through 180 days. Results Among 68 581 patients included in 2022 2023 (6239 [9.1%] 16 947 [24.7%] 45 395 [66.2%] COVID-19) 72 939 2024 (9748 [13.4%] 19 242 [26.4%] 43 949 [60.3%] COVID-19), median (IQR) age was 66 (53-75) years, 123 090 (87.0%) male. During season, hospitalization similar COVID-19 (16.2%) influenza (16.3%) but lower at 14.3% (RD vs 1.9% [95% CI, 0.9%-2.9%]; RD 2.0% 0.8%-3.3%]). The during season slightly higher (1.0%) compared (0.7%) (RD, 0.4% 0.1%-0.6%]) season. Mortality days both seasons (2023-2024 0.8% 0.3%-1.2%]; 0.6% 0.1%-1.1%]). Higher mortality observed without previous year seasonal vaccination. In contrast, groups vaccinated against their respective infections, there no any time point influenza. Conclusions Relevance showed that, SARS-CoV-2 associated more severe than whereas less pronounced seasons, remained milder illness, mortality. Vaccination attenuated

Язык: Английский

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Assessment of the Immunodeficiency Scoring Index for predicting outcomes after Respiratory Syncytial Virus infection in Allogeneic Stem Cell Transplant recipients.

Transplantation and Cellular Therapy, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

Язык: Английский

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Severity of respiratory syncytial virus versus SARS-CoV-2 Omicron and influenza infection amongst hospitalized Singaporean adults: a national cohort study

The Lancet Regional Health - Western Pacific, Год журнала: 2025, Номер 55, С. 101494 - 101494

Опубликована: Фев. 1, 2025

Язык: Английский

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Burden of Respiratory Syncytial Virus Disease in Adults with Asthma and Chronic Obstructive Pulmonary Disease: A Systematic Literature Review

Current Allergy and Asthma Reports, Год журнала: 2025, Номер 25(1)

Опубликована: Фев. 25, 2025

Abstract Purpose of Review Accumulating data indicate that asthma and chronic obstructive pulmonary disease (COPD) increase the risk severe respiratory syncytial virus (RSV) infection. This systematic literature review assessed burden RSV among adults ≥ 18 years with or COPD. Recent Findings Data on prevalence COPD RSV-infected adults, RSV-related hospitalizations, complications, mortality were collected from studies published between January 1, 2000 November 28, 2023 in PubMed, Embase, grey literature. All extracted analyzed descriptively. Pooled estimates calculated generalized linear mixed effects model meta-analyses. Forty included. The was high, especially inpatient settings pooled (95% confidence interval) 19.3% (15.0–24.6) for 30.8% (26.1–36.0) Adults more likely to be hospitalized following infection than those without these conditions. incidence rate ratios hospitalization 2.0–3.6 (crude) 6.7–8.2 (adjusted) 3.2–13.4 9.6–9.7 most frequently reported complications exacerbation (up 64.9%) 83.0%). In-hospital case fatality rates 2.6–4.3% (asthma) 2.8–17.8% (COPD). Summary These comprehensive showing a high can used inform policy decisions around vaccines improve preventive care this high-risk population. Graphical

Язык: Английский

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Comparison of patients presenting to emergency departments infected with respiratory syncytial virus versus influenza virus: a retrospective cohort study

Journal of Clinical Virology, Год журнала: 2025, Номер 177, С. 105775 - 105775

Опубликована: Март 7, 2025

Язык: Английский

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Patient- and Community-Level Characteristics Associated With Respiratory Syncytial Virus Vaccination

JAMA Network Open, Год журнала: 2025, Номер 8(4), С. e252841 - e252841

Опубликована: Апрель 1, 2025

In 2023, the first respiratory syncytial virus (RSV) vaccines were recommended for US adults 60 years or older, but few data are available about which patients most likely to receive vaccine inform future RSV outreach efforts. To assess patient- and community-level characteristics associated with receipt patient knowledge attitudes related disease vaccines. During season of use from October 1, April 30, 2024, older hospitalized RSV-negative acute illness enrolled in this cross-sectional study 26 hospitals 20 states. Sociodemographic clinical abstracted health records, structured interviews conducted Age, sex, race ethnicity, pulmonary disease, immunocompromised status, long-term care facility residence, medical insurance, social vulnerability index (SVI), educational level. The exposures identified a priori as possible factors entered into modified Poisson regression model accounting state clustering, association receipt. Knowledge summarized frequencies proportions. Among 6746 median age was 73 (IQR, 66-80) 3451 (51.2%) female. 6599 self-reported 699 (10.6%) Hispanic, 1288 (19.5%) non-Hispanic Black, 4299 (65.1%) White, 313 (4.7%) other ethnicity. There 700 RSV-vaccinated (10.4%) 6046 unvaccinated (89.6%) adults. 3219 who responded questions, 1519 (47.2%) had not heard unsure; 2525 3218 (78.5%) unsure if they eligible thought not. adjusted analyses, vaccination being 75 (adjusted risk ratio [ARR], 1.23; 95% CI, 1.10-1.38, P < .001), male (ARR, 1.15; 1.01-1.30; = .04), having 1.39; 1.16-1.67; status 1.30; 1.14-1.48; low 1.47; 1.18-1.83, .001) moderate 1.21-1.79; SVI, level consisting 4 more college 2.91; 2.14-3.96; at least some technical training 1.85; 1.35-2.53; grade 12 education General Educational Development 1.44; 1.03-2.00; .03). less among residents facilities, Medicaid coverage, uninsured patients. adults, eligibility low. Older those certain conditions have received vaccine, suggesting appropriate prioritization, sociodemographic differences uptake occurred.

Язык: Английский

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Would senior citizens get vaccinated against RSV? Exploratory analysis using a novel survey instrument

Vacunas (English Edition), Год журнала: 2025, Номер 26(1), С. 100384 - 100384

Опубликована: Янв. 1, 2025

Язык: Английский

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Prevention of respiratory syncytial virus disease across the lifespan in Italy

Pneumonia, Год журнала: 2025, Номер 17(1)

Опубликована: Апрель 5, 2025

Abstract Respiratory syncytial virus (RSV) causes substantial morbidity and mortality across the lifespan, with highest burden seen in infants older adults. Recently approved immunizing agents, including long-acting neutralizing monoclonal antibodies a maternal vaccine for passive immunization of newborns, three vaccines adults aged 60 years who are vulnerable to RSV disease, have potential prevent severe RSV-associated disease if implemented successfully. The use these agents will be some Italian regions over next few months, although no consistent timelines or decisions adoption at national level expected. A multidisciplinary group experts neonatology, obstetrics gynecology, respiratory medicine, geriatric hygiene, public health reviewed evidence on prevention present here their considerations implementing an strategy Italy. Given associated burden, it is essential move quickly deploy populations, enhance surveillance accurately detect/predict seasonal trends activity measure impact strategies. Continuing research combined widespread more sensitive testing needed identify populations risk factors. Policies support preventive measures healthcare system, access must accompanied by educational initiatives advocacy promote acceptance HCPs target population.

Язык: Английский

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Biocompatible lipid nanovehicles for preventive and therapeutic vaccine development

Coordination Chemistry Reviews, Год журнала: 2025, Номер 538, С. 216718 - 216718

Опубликована: Апрель 22, 2025

Язык: Английский

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RSV Risk Profile in Hospitalized Adults and Comparison with Influenza and COVID-19 Controls in Valladolid, Spain, 2010–2022

Infectious Diseases and Therapy, Год журнала: 2024, Номер 13(9), С. 1983 - 1999

Опубликована: Июль 21, 2024

We aimed to describe the risk profile of respiratory syncytial virus (RSV) infections among adults ≥ 60 years in Valladolid from January 2010 August 2022, and compare them with influenza COVID-19 controls. This was a retrospective cohort study all laboratory-confirmed RSV identified centralized microbiology database during 12-year period. analyzed factors for hospitalization severity (length stay, intensive care unit admission, in-hospital death or readmission < 30 days) compared between patients vs. controls using multivariable logistic regression models. included 706 (635 inpatients 71 outpatients), 598 hospitalized comparable sociodemographic profile. Among patients, 96 (15%) had subtype identified: 56% A, 42% B, 2% A + B. Eighty-one percent cardiovascular conditions, 65% endocrine/metabolic, 46% chronic lung, 43% immunocompromising conditions. Thirty-six were coinfected (vs. 21% 20% COVID-19; p = .0001 0.01). Ninety-two signs lower infection 85% 72% COVID-19, .0001) 27% 8% 0.0031 0.0009). Laboratory parameters anemia, inflammation, hypoxemia highest RSV. RSV, being previous smoker (adjusted OR 2.81 [95% CI 1.01, 7.82]), coinfection (4.34 [2.02, 9.34]), having (3.79 [2.17, 6.62]), neurologic (2.20 [1.09, 4.46]), lung (1.93 [1.11, 3.38]) diseases risks hospitalization. Being resident institutions (1.68 2.61]) (1.91[1.36, 2.69]) higher severity, while not associated severity. Whereas did show differences 68% (38–84%) odds experiencing any severe outcome COVID-19. especially affects those comorbidities, coinfections, living institutions. vaccination could have an important public health impact this population.

Язык: Английский

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