Chronic traumatic encephalopathy: State-of-the-science update and narrative review

The Clinical Neuropsychologist, Год журнала: 2025, Номер unknown, С. 1 - 25

Опубликована: Янв. 20, 2025

The long-recognized association of brain injury with increased risk dementia has undergone significant refinement and more detailed study in recent decades. Chronic traumatic encephalopathy (CTE) is a specific neurodegenerative tauopathy related to prior exposure repetitive head impacts (RHI). We aim contextualize CTE within historical perspective among emerging data which highlights the scientific conceptual evolution CTE-related research parallel broader field disease dementia. provide narrative state-of-the-science update on neuropathology, clinical manifestations, biomarkers, different types patterns impact relevant for CTE, complicated influence co-pathology symptoms. Now almost 20 years since initial case report former American football player, continues evolving increasing clarity but also several ongoing controversies. Our understanding neuropathology outpaces that disease-specific correlates or development in-vivo biomarkers. Diagnostic criteria symptoms attributable are still being validated, leveraging increasingly available biomarkers other conditions like Alzheimer's may be helpful informing differential diagnosis. As diagnostic efforts advance, clinicians should care and/or referrals providers best suited treat an individual patient's symptoms, many have evidence-based behavioral treatment options etiologically agnostic. Several initiatives gradual accrual gold standard clinico-pathological will pay dividends advancing existing gaps CTE.

Язык: Английский

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A structural haplotype in the 17q21.31 MAPT region is associated with increased risk for chronic traumatic encephalopathy endophenotypes

Cell Reports Medicine, Год журнала: 2025, Номер unknown, С. 102084 - 102084

Опубликована: Апрель 1, 2025

Язык: Английский

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Catecholamine Dysregulation in Former American Football Players

Neurology, Год журнала: 2025, Номер 104(10)

Опубликована: Апрель 21, 2025

Disturbances in brain catecholamine activity may be associated with symptoms after exposure to repetitive head impacts (RHIs) or related chronic traumatic encephalopathy (CTE). In this article, we studied CSF catecholamines former professional and college American football players examined the relationship proxies of RHI exposure, CTE probability, cognitive performance, neuropsychiatric symptoms, parkinsonism. observational cross-sectional study, male players, ("PRO") ("COL") level, asymptomatic unexposed ("UE") individuals from DIAGNOSE Research Project. Catecholamines-norepinephrine (NE) its metabolite, 3,4-dihydroxyphenylglycol (DHPG), dopamine (DA) precursor, 3,4-dihydroxyphenylalanine (l-DOPA), 3,4-dihydroxyphenylacetic acid (DOPAC)-were measured high-performance liquid chromatography compared across groups analysis covariance. Multivariable linear regression models tested between (e.g., total years playing football), factor scores for cognition, neurobehavioral dysregulation (explosivity, emotional dyscontrol, impulsivity, affective lability), as well depressive/anxiety Beck Depression/Anxiety Inventories. probability parkinsonism were assessed using National Institute Neurological Disorders Stroke consensus diagnostic criteria syndrome (TES), biomarkers among different groups. The cohort consisted 120 (85 PRO 35 COL players) UE participants (age 45-75). Former had significantly lower levels NE (mean difference = -0.114, 95% CI -0.190 -0.038), l-DOPA (-0.121, -0.109 -0.027), DOPAC (-0.116, -0.177 -0.054) than participants. For DOPAC, these overall group differences primarily due cohorts. No significant found TES-CTE subgroups TES-parkinsonism Within cohort, post hoc analyses, higher scores, BAI score, worse executive functioning processing speed. DHPG impulsivity only subgroup. We observed reduced concentrations elite although degree clinical impact needs further study.

Язык: Английский

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Substantia(l) Impacts of Contact Sport Play and Parkinsonism

JAMA Neurology, Год журнала: 2024, Номер 81(9), С. 909 - 909

Опубликована: Июль 15, 2024

Язык: Английский

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