Gut-brain axis as a bridge in obesity and depression: Mechanistic exploration and therapeutic prospects DOI

Ruiying Fang,

Xiaoxia Pan, Xuejun Zeng

и другие.

World Journal of Psychiatry, Год журнала: 2024, Номер 15(1)

Опубликована: Дек. 18, 2024

A recent study by Wang et al, published in the World Journal of Psychiatry, provided preventative and therapeutic strategies for comorbidity obesity depression. The gut-brain axis, which acts as a two-way communication system between gastrointestinal tract central nervous system, plays pivotal role pathogenesis these conditions. Evidence suggests that metabolic byproducts, such short-chain fatty acids, lipopolysaccharide bile are generated gut microbiota, along with neurotransmitters inflammatory mediators within modulate host's processes, neuronal regulation, immune responses through diverse mechanisms. interaction depression via axis involves disruptions microbiota balance, responses, alterations neuroendocrine system. Modulating example, ketogenic diet, use probiotics, supplementation antioxidants, offers new remedial approaches Future research explores mechanisms is needed to provide more evidence clinical treatment.

Язык: Английский

Preventing weight gain in adults who emotionally eat: An open pilot DOI
Rachel W. Goode, Loneke T. Blackman Carr, Yiwen Xu

и другие.

Eating Behaviors, Год журнала: 2025, Номер 57, С. 101960 - 101960

Опубликована: Фев. 21, 2025

Язык: Английский

Процитировано

0

The Effect of Motivational Interview‐Based Education on Nutrition Exercise Behavior, Sedentary Activity Duration, and Anthropometric Outcomes in Obese Adolescents DOI
Hasan EVCİMEN, Sonay Bilgin

Public Health Nursing, Год журнала: 2025, Номер unknown

Опубликована: Янв. 2, 2025

ABSTRACT Purpose The aim of this study was to examine the effect motivational interview‐based training on nutrition exercise behavior, sedentary behavior duration, and anthropometric outcomes in adolescents. Method This randomized controlled single‐blind experimental conducted between January 2021 March 2023. research sample consisted 76 adolescents with obesity (intervention: 38 control: 38) determined by power analysis. intervention group received a 6‐session program. No applied control group. Data were collected using personal information form, scale, adolescent activity questionnaire, body mass ındex measurement form. collection tools administered both groups before intervention, at last session 3rd month follow‐up. In analysis data, chi‐square test, independent t ‐test two‐way mixed design ANOVA used. Results There no statistically significant difference pretest index z‐scores ( p > 0.05). After education program, behaviors improved : 0.00), duration BMI decreased 0.00) observed Nutritional values showed compared 0.00). Conclusıon It that interviewing created positive change nutritional durations, results. is recommended nurses should use management obesity. Trial Registration Clinical Trials ID: NCT05268653.

Язык: Английский

Процитировано

0

Brief Cognitive Analytic Therapy (CAT)‐Informed Reformulation for Young People With Eating Disorders: A Case Series DOI Creative Commons
C. Green, Gail Mannion,

I. Gill

и другие.

Clinical Psychology & Psychotherapy, Год журнала: 2025, Номер 32(2)

Опубликована: Март 1, 2025

Onset of Eating Disorder (ED) peaks in young people, and interpersonal factors can influence development maintenance. With increased referrals to ED services, accessible, brief interventions may support early intervention improve outcomes. Cognitive Analytic Therapy (CAT) is a transdiagnostic relational approach, which offer benefit for range presenting difficulties. This study aimed assess the feasibility acceptability brief, CAT-informed reformulation people with ED. A case series design recruited eight who met inclusion exclusion criteria participate five-session intervention. Recruitment took place from NHS services. Feasibility were measured via recruitment, retention, qualitative feedback missing data. Psychological distress, severity, personal recovery motivation change assessed at baseline, post-intervention follow-up. Participants also completed sessional measures psychological distress alliance. Eight eligible participants aged 15-24 years (M = 20.25, SD 3.58) consented take part received All attended all sessions assessments. reported positive experiences There was an associated reduction across clinical outcomes, including severity. showed promising results on However, had small sample size no comparator control group. Larger scale exploration EDs among warranted. The preregistered clinicaltrials.gov (NCT05746364).

Язык: Английский

Процитировано

0

Efficacy, Safety and Acceptability of a Very-Low-Energy Diet in Adolescents with Obesity: A Fast Track to Health Sub-Study DOI Open Access
Megan L. Gow, Hiba Jebeile, Eve T House

и другие.

Nutrients, Год журнала: 2024, Номер 16(18), С. 3125 - 3125

Опубликована: Сен. 16, 2024

The aim of this study was to determine the efficacy, safety and acceptability a 4-week very-low-energy diet (VLED) program for adolescents with obesity. Adolescents (13–17 years) obesity ≥1 obesity-related complication were Fast Track Health 52-week randomized controlled trial participants. undertook micronutrient-complete VLED (800 kcal/day), weekly dietitian support. Anthropometric data recorded at baseline week-4 side-effects day 3–4, week-1, -2, -3 -4. completed an survey week-4. A total 134 (14.9 ± 1.2 years, 50% male) had 5.5 2.9 kg (p < 0.001) mean weight loss week-4: 95% experienced 70% ≥3 during program, especially first week. Hunger, fatigue, headache, irritability, loose stools, constipation nausea most common. Reporting more 3–4 correlated greater (r = −0.188, p 0.03). reported ‘losing weight’ (34%) ‘prescriptive structure’ (28%) as positive aspects VLED, while ‘restrictive nature’ (45%) ‘meal replacement taste’ (20%) least liked. dietitian-monitored short-term can be implemented safely is acceptable many seeking loss, despite frequent side-effects. Investigating predictors effectiveness could suited programs.

Язык: Английский

Процитировано

2

Intermittent fasting as a treatment for obesity in young people: a scoping review DOI Creative Commons
Jomanah A. Bakhsh, Sarah‐Jeanne Salvy, Alaina P. Vidmar

и другие.

npj Metabolic Health and Disease, Год журнала: 2024, Номер 2(1)

Опубликована: Дек. 30, 2024

Intermittent fasting focuses on the timing of eating rather than diet quality or energy intake, with evidence supporting its effects weight loss and improvements in cardiometabolic outcomes adults obesity. However, there is limited for feasibility efficacy young people. To address this, a scoping review was conducted to examine intermittent regimens individuals aged 10 25 treatment obesity focusing methodology, intervention parameters, outcomes, adherence, feasibility, efficacy. Due paucity this age group, adequately assess all published studies category, regardless status intention, were included review. The 34 (28 interventional 6 observational studies) 893 participants 12 25. Interventions varied 9 cohorts utilizing as an treatment. Thirteen utilized 8-h time-restricted eating. Primary risk factors (7/28), anthropometric measurements body composition (5/28), muscular performance (4/28), (1/28), others (4/28). All people reported some degree loss, although comparator groups significantly. This underscores various utilizations group highlights potential treating findings emphasize need rigorous standardized frameworks ensure comparability determine fasting's practicality depending outcome interest.

Язык: Английский

Процитировано

1

Gut-brain axis as a bridge in obesity and depression: Mechanistic exploration and therapeutic prospects DOI

Ruiying Fang,

Xiaoxia Pan, Xuejun Zeng

и другие.

World Journal of Psychiatry, Год журнала: 2024, Номер 15(1)

Опубликована: Дек. 18, 2024

A recent study by Wang et al, published in the World Journal of Psychiatry, provided preventative and therapeutic strategies for comorbidity obesity depression. The gut-brain axis, which acts as a two-way communication system between gastrointestinal tract central nervous system, plays pivotal role pathogenesis these conditions. Evidence suggests that metabolic byproducts, such short-chain fatty acids, lipopolysaccharide bile are generated gut microbiota, along with neurotransmitters inflammatory mediators within modulate host's processes, neuronal regulation, immune responses through diverse mechanisms. interaction depression via axis involves disruptions microbiota balance, responses, alterations neuroendocrine system. Modulating example, ketogenic diet, use probiotics, supplementation antioxidants, offers new remedial approaches Future research explores mechanisms is needed to provide more evidence clinical treatment.

Язык: Английский

Процитировано

0