Low-frequency rTMS modulates small-world network properties in an AVH-related brain network in schizophrenia DOI Creative Commons
Lin Zhang, Li Guo, Xiaohui Liu

и другие.

Frontiers in Psychiatry, Год журнала: 2025, Номер 16

Опубликована: Апрель 15, 2025

Background Auditory verbal hallucinations (AVH) are a core symptom of schizophrenia, often persisting despite pharmacological treatment. Repetitive transcranial magnetic stimulation (rTMS), particularly low-frequency rTMS targeting the left temporoparietal junction (TPJ), has shown promise in alleviating AVH symptoms by modulating dysfunctional brain connectivity. However, network-level effects remain incompletely understood, terms small-world network properties, which provide insights into local and global efficiency. Furthermore, most previous studies have analyzed whole-brain networks, lacking specificity regarding disease-relevant circuits. Objective This study aimed to investigate how modulates properties refined AVH-related composed 35 regions specifically implicated hallucination generation treatment effects, thereby providing more targeted perspective on reorganization. Healthy controls (HCs) were included as reference determine whether normalizes alterations schizophrenia. Additionally, responder vs. non-responder analysis was conducted assess individual variability response. Methods A total 50 schizophrenia patients with persistent underwent 15 sessions 1 Hz over TPJ. Resting-state fMRI data collected before after functional connectivity within predefined 35-region network. small-worldness (σ), normalized clustering coefficient (γ), characteristic path length (λ), well segregation (clustering [Cp], efficiency [El]) integration (global [Eg], [Lp])—were rTMS. Clinical severity assessed using Hallucination Rating Scale (AHRS). Results At baseline, exhibited disrupted significantly lower σ, Cp, El, Eg compared healthy controls, reflecting impaired organization, reduced clustering, inefficient communication. Following rTMS, (El), (Eg) showed significant improvement, suggesting partial restoration Functional analyses revealed reductions hyperconnectivity between right middle temporal gyrus (MTG) superior putamen, TPJ lateral prefrontal cortex (LPFC). Notably, responders greater changes, correlated reduction, highlighting role modulation Conclusion These findings support dysregulation model demonstrate that can modulate connectivity, partially restoring The inclusion HCs provides evidence rTMS-induced changes align normative patterns, suggests is linked clinical improvement. offers new neurobiological mechanisms underscores need for biomarker-driven, individualized neuromodulation strategies

Язык: Английский

Low-frequency rTMS modulates small-world network properties in an AVH-related brain network in schizophrenia DOI Creative Commons
Lin Zhang, Li Guo, Xiaohui Liu

и другие.

Frontiers in Psychiatry, Год журнала: 2025, Номер 16

Опубликована: Апрель 15, 2025

Background Auditory verbal hallucinations (AVH) are a core symptom of schizophrenia, often persisting despite pharmacological treatment. Repetitive transcranial magnetic stimulation (rTMS), particularly low-frequency rTMS targeting the left temporoparietal junction (TPJ), has shown promise in alleviating AVH symptoms by modulating dysfunctional brain connectivity. However, network-level effects remain incompletely understood, terms small-world network properties, which provide insights into local and global efficiency. Furthermore, most previous studies have analyzed whole-brain networks, lacking specificity regarding disease-relevant circuits. Objective This study aimed to investigate how modulates properties refined AVH-related composed 35 regions specifically implicated hallucination generation treatment effects, thereby providing more targeted perspective on reorganization. Healthy controls (HCs) were included as reference determine whether normalizes alterations schizophrenia. Additionally, responder vs. non-responder analysis was conducted assess individual variability response. Methods A total 50 schizophrenia patients with persistent underwent 15 sessions 1 Hz over TPJ. Resting-state fMRI data collected before after functional connectivity within predefined 35-region network. small-worldness (σ), normalized clustering coefficient (γ), characteristic path length (λ), well segregation (clustering [Cp], efficiency [El]) integration (global [Eg], [Lp])—were rTMS. Clinical severity assessed using Hallucination Rating Scale (AHRS). Results At baseline, exhibited disrupted significantly lower σ, Cp, El, Eg compared healthy controls, reflecting impaired organization, reduced clustering, inefficient communication. Following rTMS, (El), (Eg) showed significant improvement, suggesting partial restoration Functional analyses revealed reductions hyperconnectivity between right middle temporal gyrus (MTG) superior putamen, TPJ lateral prefrontal cortex (LPFC). Notably, responders greater changes, correlated reduction, highlighting role modulation Conclusion These findings support dysregulation model demonstrate that can modulate connectivity, partially restoring The inclusion HCs provides evidence rTMS-induced changes align normative patterns, suggests is linked clinical improvement. offers new neurobiological mechanisms underscores need for biomarker-driven, individualized neuromodulation strategies

Язык: Английский

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