A Framework for Assessment of Adverse Events Occurring in Psychedelic Assisted Therapies DOI Open Access
Roman Palitsky, Deanna M. Kaplan,

John Perna

и другие.

Опубликована: Март 5, 2024

Objective: Despite considerable research examining the efficacy of psychedelic-assisted therapies (PATs) for treating psychiatric disorders, assessment adverse events (AEs) in PAT has lagged. Current AE reporting standards trials are poorly calibrated to features that distinguish it from other treatments, leaving many potential AEs unassessed.Methods: A multidisciplinary working group experts involved pooled formally and informally documented observed through experience published literature. This information was integrated with (a) current practices pharmacotherapy psychotherapy trials, (b) findings documenting post-acute dosing impacts psychedelics on subjective states, meaning, psychosocial health variables, produce a set constructs important evaluate as well recommended methods time frames their monitoring. Correspondence between identified examined, including extent coverage by 22 existing measures used relevant research. Results: 53 terms warranting systematized were identified, defined, categorized. Existing demonstrated substantial gaps constructs. Recommendations developed how assess (including patient, clinician, informant reports), when over preparation, session, integration, follow-up. Conclusions: framework addresses need capture PAT, accounting its components, worldviews spirituality.

Язык: Английский

Experiential Training in Psychedelic‐Assisted Therapy: A Risk‐Benefit Analysis DOI Creative Commons
Daniel Rosenbaum,

Crystal Hare,

Emma Hapke

и другие.

The Hastings Center Report, Год журнала: 2024, Номер 54(4), С. 32 - 46

Опубликована: Июль 1, 2024

Abstract Well‐trained, competent therapists are crucial for safe and effective psychedelic‐assisted therapy (PAT). The question whether PAT training programs should require aspiring to undergo their own PAT—commonly referred as “experiential training”—has received much attention within the field. In this article, we analyze potential benefits of experiential in by applying framework developed Rolf Sandell et al. concerning functions any (the therapeutic, modeling, empathic, persuasive, theoretical functions). We then explore six key domains which risks could arise through mandatory training: physical psychological risks; negative impact on therapeutic skill; justice, equity, diversity, inclusion; dual relationships; privacy confidentiality; undue pressure. Ultimately, argue that not be mandatory. Because many already incorporate methods, our exploration harms may used generate comprehensive risk‐mitigation strategies .

Язык: Английский

Процитировано

5
A Psilocybin Experience Gone Wrong: The Importance of Psychedelic Assisted Psychotherapy DOI
Fernando Espí Forcén

Journal of Psychoactive Drugs, Год журнала: 2025, Номер unknown, С. 1 - 3

Опубликована: Янв. 7, 2025

As psilocybin awaits approval by the Food and Drug Administration (FDA), scholars debate whether psychedelic-assisted psychotherapy should be required when prescribing this medicine. Here, we report case of a patient who underwent experience without psychotherapy, resulting in inpatient psychiatric admission. This underscores importance taking controlled clinical settings. Moreover, discuss how could have altered outcome her role experiential learning psychedelics for potential prescribers.

Язык: Английский

Процитировано

0
Psychedelic Ethics in Palliative Care DOI
Keenan Davis, Roman Palitsky, Boadie W. Dunlop

и другие.

The American Journal of Bioethics, Год журнала: 2025, Номер 25(1), С. 95 - 98

Опубликована: Янв. 2, 2025

Язык: Английский

Процитировано

0
Emerging Medications for Treatment-Resistant Depression: A Review with Perspective on Mechanisms and Challenges DOI Creative Commons
Michael J. Lucido, Boadie W. Dunlop

Brain Sciences, Год журнала: 2025, Номер 15(2), С. 161 - 161

Опубликована: Фев. 6, 2025

Background/Objectives: Non-response to initial treatment options for major depressive disorder (MDD) is a common clinical challenge with profound deleterious impacts affected patients. Few treatments have received regulatory approval treatment-resistant depression (TRD). Methods: A systematic search of United States and European Union trials registries was conducted identify Phase II, III, or IV trials, last update posted on after 1 January 2020, that were evaluating medications TRD. For both the US EU registries, condition term "treatment resistant depression" associated lower-level terms (per registry protocol) used. registry, secondary using "depressive disorders" modifying "inadequate" also performed capture registrations not tagged as Two additional searches in "suicide" "anhedonia" transdiagnostic targets investigational medications. Trials categorized based primary mechanism action trial's medication. Results: Fifty TRD, 20 anhedonia, 25 suicide identified. Glutamate system modulation currently most compounds development, including antagonists allosteric modulators NMDA receptors, AMPA metabotropic type 2/3 glutamate intracellular effector molecules downstream signaling. Psychedelics seen greatest surge among mechanistic past 5 years, however, psilocybin particular garnering significant attention. Other mechanisms included GABA modulators, monoamine anti-inflammatory/immune-modulating agents, an orexin 2 receptor antagonist. Conclusions: These investigations offer substantial promise more efficacious potentially personalized medication approaches Challenges detecting efficacy TRD include heterogeneity within population stemming from presumed variety biological dysfunctions underlying disorder, comorbid disorders, chronic psychosocial stressors, enduring effects prior serotonergic antidepressant treatments.

Язык: Английский

Процитировано

0
Exploring the Role of Psychedelic Experiences on Wellbeing and Symptoms of Disordered Eating DOI Creative Commons

Nadine Loh,

David Luke

Psychoactives, Год журнала: 2025, Номер 4(1), С. 7 - 7

Опубликована: Март 4, 2025

Accumulating psychedelic research has demonstrated a potential for improving mental health and wellbeing, yet studies in the context of eating disorders (EDs) are limited. This study aims to explore subjective effects experiences gain insight into benefits risks people with EDs. Semi-structured interviews were conducted eight adults aged 25–54 (mean age = 36.9), reporting have had EDs psychedelics both naturalistic clinical settings. Participants multiple diagnoses suffered chronic EDs, onset 13), diagnosed (N 7) undiagnosed 1). Reports cessation or reduction ED symptoms unanimous long-lasting seven, two participants recovery attributed use. Two reported relapsing, environmental factors months following. Thematic analysis resulted superordinate themes, each comprising three subordinate themes. The first theme, ‘Exploring’ via ‘gateway healing’, illustrates mental, emotional, transcendental elements experiences. second ‘Transformation’ being ‘able do work’, cognitive behavioural outcomes, retrospective safety perceptions. These findings may provide more in-depth information on what can obtain from use drugs inform robust investigations psychedelic-assisted therapy treatment

Язык: Английский

Процитировано

0
Psychedelic iatrogenic structural dissociation: an exploratory hypothesis on dissociative risks in psychedelic use DOI Creative Commons

Steven Elfrink,

Leigh Bergin

Frontiers in Psychology, Год журнала: 2025, Номер 16

Опубликована: Март 4, 2025

This paper introduces the hypothesis of Psychedelic Iatrogenic Structural Dissociation (PISD), proposing that psychedelics may reactivate dissociated traumatic material, increasing risk psychological destabilization in trauma-exposed individuals. Grounded structural dissociation theory, this framework suggests can disrupt balance between daily functioning (the Apparently Normal Personality, ANP) and trauma-related responses Emotional EP), leading to resurfacing unintegrated memories. A review recent studies highlights persistent adverse effects associated with psychedelic use, including emotional dysregulation, identity fragmentation, derealization, perceptual disturbances, particularly among individuals early trauma histories. To mitigate these risks facilitate processing, integration practices, body-focused therapies, structured social support systems are proposed as key interventions. Additionally, emerging neurophysiological models suggest reconfigure dissociative processes through modulation entrenched patterns, potentially facilitating or vulnerability destabilization, depending on individual contextual factors. These findings underscore necessity trauma-informed screening, preparation, protocols enhance safety efficacy for vulnerable populations.

Язык: Английский

Процитировано

0
Self-treatment with psychedelic substances for health and wellbeing in Aotearoa New Zealand: an exploratory descriptive study DOI Creative Commons
Chris Arnison, Richard Egan, John H. Shaver

и другие.

Kōtuitui New Zealand Journal of Social Sciences Online, Год журнала: 2025, Номер unknown, С. 1 - 22

Опубликована: Март 6, 2025

This study draws attention to, and provides a description of, previously unmapped emerging self-medication phenomenon occurring in Aotearoa New Zealand where psychedelic substances are being used the absence of clinical supervision to address wide range health wellbeing issues, partly response unmet mental needs. We interviewed 34 individuals who had self-administered psychedelics with intention improving their or thematic analysis generate themes from interview data that capture salient characteristics this practice. found variety concerns, often after other treatment options have been exhausted. Those we spoke described personalised strategies using which were intended enhance efficacy reduce likelihood adverse outcomes. Positive results, including symptom remission across disorders general improvements psychological wellbeing, alleged. highlight concerns raises for practice, offer suggestions reducing potential harms associated it, draw aspects naturalistic use future trials might consider exploring more systematically.

Язык: Английский

Процитировано

0
Societal Trends and Opportunities in the Aftermath of the Nova Psychedelic Trance Rave, Through Lilla and Benjamin DOI Creative Commons
Demian Halperin,

Tal Bar On,

Nir Tadmor

и другие.

Future Humanities, Год журнала: 2025, Номер 3(1)

Опубликована: Фев. 25, 2025

ABSTRACT This fiction article is about trauma and grief, resilience the celebration of life. It also addresses role psychedelics can play in bringing change our traumatized society by inspiring us showing how to use present as a possibility for fundamental transformation. written form short story exemplify these substances work underline critical importance challenging protocols conventional ways thinking, opening up space unexpected. The discusses societal trends, either already noticeable or hoped for, aftermath terror attack on Nova music festival Re'im, Israel, October 7, 2023, where roughly two‐third partygoers were under influence psychedelics. Lilla, fictitious main protagonist, first describes her experience that day, at interface trauma. part influenced observations from clinical with survivors well preliminary insights phenomenological study. She then goes share fears, thoughts visions, initiating discussion society. Read through lens Walter Benjamin's historical materialism, dialectics between past present, old new, we believe provide view while allowing envision this moment be seized an opportunity, right now, creating break continuum history!

Язык: Английский

Процитировано

0
Metacognitive Feelings of Epistemic Gain are Central to the Understanding of Psychedelic-Induced Mystical-Type Experiences DOI Creative Commons
Federico Seragnoli, Fabienne Picard, Gabriel Thorens

и другие.

Cognitive Therapy and Research, Год журнала: 2025, Номер unknown

Опубликована: Март 29, 2025

Язык: Английский

Процитировано

0
Evaluating the effectiveness of psilocybin in alleviating distress among cancer patients: A systematic review DOI
Maria I. Lapid, Sandeep R. Pagali,

A Randall

и другие.

Palliative & Supportive Care, Год журнала: 2025, Номер 23

Опубликована: Янв. 1, 2025

Abstract Objectives Psychological and existential distress is prevalent among patients with life-threatening cancer, significantly impacting their quality of life. Psilocybin-assisted therapy has shown promise in alleviating these symptoms. This systematic review aims to synthesize the evidence on efficacy safety psilocybin reducing cancer-related distress. Methods We searched MEDLINE, APA PsycINFO, Cochrane database, Embase, Scopus from inception February 8, 2024, for randomized controlled trials (RCTs), open-label trials, qualitative studies, single case reports that evaluated Data were extracted study characteristics, participant demographics, psychotherapy intervention, outcome measures, results. Two authors independently screened, selected, data studies. Risk Bias RCTs Methodological Index Non-Randomized Studies criteria used evaluate quality. was registered PROSPERO (CRD42024511692). Results Fourteen studies met inclusion criteria, comprising three RCTs, five one report. Psilocybin consistently showed significant reductions depression, anxiety, distress, improvements sustained over several months. Adverse effects generally mild transient. Significance results highlights potential psilocybin-assisted as an effective treatment psychological cancer patients. Despite promising findings, further large-scale, well-designed are needed confirm address existing research gaps.

Язык: Английский

Процитировано

0