International Journal of Biological Sciences,
Год журнала:
2025,
Номер
21(4), С. 1530 - 1544
Опубликована: Янв. 27, 2025
Globally,
bladder
cancer
is
the
tenth
most
common
cancer.
Mitophagy,
a
critical
process
regulating
mitochondrial
quantity
and
quality,
has
attracted
increasing
attention
for
its
pivotal
function
in
Nonetheless,
roles
underlying
mechanisms
are
yet
to
be
elucidated.
Therefore,
this
study,
16
mitophagy-related
genes
were
screened
construct
robust
prognostic
model
with
exceptional
predictive
accuracy
outcomes
of
patients
Of
these
genes,
DARS2
was
identified
as
key
regulator
that
significantly
affected
progression.
The
findings
established
promoted
G1-to-S
phase
transition
by
upregulating
CDK4
expression,
thereby
suppressing
cellular
senescence
driving
cell
proliferation.
In
addition,
augmented
PINK1
leading
increased
PINK1-mediated
mitophagy.
Both
vitro
vivo
experiments
confirmed
inhibited
facilitated
tumor
progression
enhancing
observations
from
study
have
provided
novel
insights
into
multifaceted
DARS2-mediated
mitophagy
Targeting
regulation
promising
therapeutic
strategy
improve
Ageing Research Reviews,
Год журнала:
2024,
Номер
97, С. 102315 - 102315
Опубликована: Апрель 26, 2024
Lung
cancer
stands
as
the
primary
contributor
to
cancer-related
fatalities
worldwide,
affecting
both
genders.
Two
types
exist
where
non-small
cell
lung
(NSCLC),
accounts
for
80–85%
and
SCLC
10-15%
of
cases.
NSCLC
subtypes
include
adenocarcinoma,
squamous
carcinoma,
large
carcinoma.
Smoking,
second-hand
smoke,
radon
gas,
asbestos,
other
pollutants,
genetic
predisposition,
COPD
are
risk
factors.
On
hand,
stresses
such
DNA
damage,
telomere
shortening,
oncogene
activation
cause
a
prolonged
cycle
halt,
known
senescence.
Despite
its
initial
role
tumor-suppressing
mechanism
that
slows
growth,
excessive
or
improper
control
this
process
can
age-related
diseases,
including
cancer.
Cellular
senescence
has
two
purposes
in
Researchers
report
tumor
growth
by
constraining
multiplication
impaired
cells.
However,
senescent
cells
also
demonstrate
pro-inflammatory
senescence-associated
secretory
phenotype
(SASP),
which
is
widely
reported
promote
This
review
will
look
at
cellular
cancer,
describe
diagnostic
markers,
ask
about
current
treatments
it,
case
studies
clinical
trials
show
how
senescence-targeting
therapies
be
used
talk
problems
currently
being
faced,
possible
solutions
same
future.
Cell Death Discovery,
Год журнала:
2024,
Номер
10(1)
Опубликована: Фев. 5, 2024
Abstract
Cellular
senescence
represents
an
irreversible
state
of
cell-cycle
arrest
during
which
cells
secrete
senescence-associated
secretory
phenotypes,
including
inflammatory
factors
and
chemokines.
Additionally,
these
exhibit
apoptotic
resistance
phenotype.
serves
a
pivotal
role
not
only
in
embryonic
development,
tissue
regeneration,
tumor
suppression
but
also
the
pathogenesis
age-related
degenerative
diseases,
malignancies,
metabolic
kidney
diseases.
The
renal
tubular
epithelial
(RTEC)
constitutes
critical
cellular
event
progression
acute
injury
(AKI).
RTEC
inhibits
regeneration
repair
processes
and,
concurrently,
promotes
transition
AKI
to
chronic
disease
via
mechanisms
underlying
are
multifaceted
include
telomere
shortening
or
damage,
DNA
mitochondrial
autophagy
deficiency,
disorders,
endoplasmic
reticulum
stress,
epigenetic
regulation.
Strategies
aimed
at
inhibiting
senescence,
targeting
clearance
senescent
RTEC,
promoting
apoptosis
hold
promise
for
enhancing
prognosis
AKI.
This
review
primarily
focuses
on
characteristics
impact
intervening
AKI,
aiming
provide
foundation
understanding
providing
potentially
effective
approaches
treatment.
Antioxidants,
Год журнала:
2023,
Номер
12(6), С. 1210 - 1210
Опубликована: Июнь 3, 2023
Cigarette
smoke
(CS)
poses
a
significant
risk
factor
for
respiratory,
vascular,
and
organ
diseases
owing
to
its
high
content
of
harmful
chemicals
reactive
oxygen
species
(ROS).
These
substances
are
known
induce
oxidative
stress,
inflammation,
apoptosis,
senescence
due
their
exposure
environmental
pollutants
the
presence
enzymes.
The
lung
is
particularly
susceptible
stress.
Persistent
stress
caused
by
chronic
CS
can
lead
respiratory
such
as
obstructive
pulmonary
disease
(COPD),
fibrosis
(PF),
cancer.
Avoiding
pollutants,
like
cigarette
air
pollution,
help
mitigate
A
comprehensive
understanding
impact
on
lungs
requires
future
research.
This
includes
identifying
strategies
preventing
treating
well
investigating
underlying
mechanisms
behind
Thus,
this
review
aims
investigate
cellular
processes
induced
CS,
specifically
senescence,
associated
biomarkers.
Furthermore,
will
delve
into
alveolar
response
provoked
emphasizing
roles
potential
therapeutic
target
markers
in
inflammation
Aging and Disease,
Год журнала:
2024,
Номер
unknown
Опубликована: Янв. 1, 2024
Cellular
senescence
is
characterized
by
the
permanent
arrest
of
cell
proliferation
and
a
response
to
endogenous
exogenous
stress.
The
continuous
accumulation
senescent
cells
(SnCs)
in
body
leads
development
aging
age-related
diseases
(such
as
neurodegenerative
diseases,
cancer,
metabolic
cardiovascular
osteoarthritis).
In
face
growing
challenge
several
compounds
have
received
widespread
attention
for
their
potential
target
SnCs.
As
result,
senolytics
(compounds
that
selectively
eliminate
SnCs)
senomorphics
alter
intercellular
communication
modulate
behavior
become
hot
research
topics
field
anti-aging.
addition,
strategies
such
combination
therapies
immune-based
approaches
also
made
significant
progress
anti-aging
therapy.
this
article,
we
discuss
latest
on
targeting
SnCs
gain
deeper
understanding
mechanism
action
impact
different
with
aim
providing
more
effective
references
therapeutic
ideas
clinical
treatment
ever-grave
challenges
diseases.
