Frontiers in Immunology,
Год журнала:
2024,
Номер
15
Опубликована: Март 5, 2024
The
development
of
age-associated
diseases
is
related
to
the
accumulation
senescent
cells
in
body.
These
are
old
non-functional
with
impaired
metabolism,
which
unable
divide.
Such
also
resistant
programmed
cell
death
and
prone
spontaneous
production
some
inflammatory
factors.
dysfunction
organs
tissues
as
well
chronic
inflammation
that
enhances
age.
In
young
organism,
removed
innate
immunity
system.
However,
efficiency
this
process
decreases
Nowadays,
more
evidences
accumulating
support
involvement
specific
T-lymphocytes
fight
against
cells.
It
has
great
physiological
importance
since
efficient
elimination
requires
a
high
diversity
antigen-recognizing
receptors
cover
entire
spectrum
senescent-associated
antigens
precision
specificity.
Developing
approaches
T-cell
stimulation
generate
or
amplify
immune
response
can
provide
new
perspectives
extend
active
longevity.
mini-review,
authors
summarize
current
understanding
role
discuss
prospects
stimulating
adaptive
for
combating
occurs
Ageing Research Reviews,
Год журнала:
2024,
Номер
97, С. 102315 - 102315
Опубликована: Апрель 26, 2024
Lung
cancer
stands
as
the
primary
contributor
to
cancer-related
fatalities
worldwide,
affecting
both
genders.
Two
types
exist
where
non-small
cell
lung
(NSCLC),
accounts
for
80–85%
and
SCLC
10-15%
of
cases.
NSCLC
subtypes
include
adenocarcinoma,
squamous
carcinoma,
large
carcinoma.
Smoking,
second-hand
smoke,
radon
gas,
asbestos,
other
pollutants,
genetic
predisposition,
COPD
are
risk
factors.
On
hand,
stresses
such
DNA
damage,
telomere
shortening,
oncogene
activation
cause
a
prolonged
cycle
halt,
known
senescence.
Despite
its
initial
role
tumor-suppressing
mechanism
that
slows
growth,
excessive
or
improper
control
this
process
can
age-related
diseases,
including
cancer.
Cellular
senescence
has
two
purposes
in
Researchers
report
tumor
growth
by
constraining
multiplication
impaired
cells.
However,
senescent
cells
also
demonstrate
pro-inflammatory
senescence-associated
secretory
phenotype
(SASP),
which
is
widely
reported
promote
This
review
will
look
at
cellular
cancer,
describe
diagnostic
markers,
ask
about
current
treatments
it,
case
studies
clinical
trials
show
how
senescence-targeting
therapies
be
used
talk
problems
currently
being
faced,
possible
solutions
same
future.
Cell Death Discovery,
Год журнала:
2024,
Номер
10(1)
Опубликована: Фев. 5, 2024
Abstract
Cellular
senescence
represents
an
irreversible
state
of
cell-cycle
arrest
during
which
cells
secrete
senescence-associated
secretory
phenotypes,
including
inflammatory
factors
and
chemokines.
Additionally,
these
exhibit
apoptotic
resistance
phenotype.
serves
a
pivotal
role
not
only
in
embryonic
development,
tissue
regeneration,
tumor
suppression
but
also
the
pathogenesis
age-related
degenerative
diseases,
malignancies,
metabolic
kidney
diseases.
The
renal
tubular
epithelial
(RTEC)
constitutes
critical
cellular
event
progression
acute
injury
(AKI).
RTEC
inhibits
regeneration
repair
processes
and,
concurrently,
promotes
transition
AKI
to
chronic
disease
via
mechanisms
underlying
are
multifaceted
include
telomere
shortening
or
damage,
DNA
mitochondrial
autophagy
deficiency,
disorders,
endoplasmic
reticulum
stress,
epigenetic
regulation.
Strategies
aimed
at
inhibiting
senescence,
targeting
clearance
senescent
RTEC,
promoting
apoptosis
hold
promise
for
enhancing
prognosis
AKI.
This
review
primarily
focuses
on
characteristics
impact
intervening
AKI,
aiming
provide
foundation
understanding
providing
potentially
effective
approaches
treatment.
Antioxidants,
Год журнала:
2023,
Номер
12(6), С. 1210 - 1210
Опубликована: Июнь 3, 2023
Cigarette
smoke
(CS)
poses
a
significant
risk
factor
for
respiratory,
vascular,
and
organ
diseases
owing
to
its
high
content
of
harmful
chemicals
reactive
oxygen
species
(ROS).
These
substances
are
known
induce
oxidative
stress,
inflammation,
apoptosis,
senescence
due
their
exposure
environmental
pollutants
the
presence
enzymes.
The
lung
is
particularly
susceptible
stress.
Persistent
stress
caused
by
chronic
CS
can
lead
respiratory
such
as
obstructive
pulmonary
disease
(COPD),
fibrosis
(PF),
cancer.
Avoiding
pollutants,
like
cigarette
air
pollution,
help
mitigate
A
comprehensive
understanding
impact
on
lungs
requires
future
research.
This
includes
identifying
strategies
preventing
treating
well
investigating
underlying
mechanisms
behind
Thus,
this
review
aims
investigate
cellular
processes
induced
CS,
specifically
senescence,
associated
biomarkers.
Furthermore,
will
delve
into
alveolar
response
provoked
emphasizing
roles
potential
therapeutic
target
markers
in
inflammation
Biomedicine & Pharmacotherapy,
Год журнала:
2023,
Номер
162, С. 114653 - 114653
Опубликована: Апрель 21, 2023
In
recent
study,
the
pathological
mechanism
of
liver
fibrosis
has
been
associated
with
hepatic
stellate
cell
(HSC)
senescence.
Targeted
induction
HSC
senescence
is
considered
as
a
new
strategy
to
remove
activated
HSC.
Nevertheless,
little
known
about
role
ferritinophagy
in
this
we
reported
that
Oroxylin
A
from
Scutellaria
baicalensis
Georgi
can
regulate
induced
by
through
cGAS-STING
pathway
reduce
fibrosis.
We
first
found
treatment
alleviated
changes
fibrosis,
reduced
collagen
deposition,
and
significantly
inhibited
Interestingly,
activate
further
induce
It
noteworthy
mediated
nuclear
receptor
coactivator
4
(NCOA4),
an
important
selective
mediator
for
ferritin
degradation.
NCOA4
siRNA
causes
degree
telomerase
activity
HSCs
expression
markers,
such
SA-β-Gal
related
marker
proteins.
Importantly,
crucial
activation
A.
Specifically,
promote
secretion
cytokines
like
IFN-β
ferritinophagy.
cGAS
resulted
dose-dependent
decrease
NCOA4,
significant
reduction
level
autophagy-related
phenotype,
content
ROS
iron
ions
HSCs.
conclusion,
identified
GAS-STING
-mediated
anti-hepatic
