Immunomodulatory mechanisms driving tumor escape in Glioblastoma: the central role of IDO and tryptophan metabolism in local and systemic immunotolerance
Critical Reviews in Oncology/Hematology,
Год журнала:
2025,
Номер
unknown, С. 104657 - 104657
Опубликована: Фев. 1, 2025
Язык: Английский
GBM immunotherapy: Exploring molecular and clinical frontiers
Life Sciences,
Год журнала:
2024,
Номер
356, С. 123018 - 123018
Опубликована: Авг. 28, 2024
Язык: Английский
A proteogenomic tool uncovers protein markers for human microglial states
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Май 2, 2025
Abstract
Human
microglial
heterogeneity
has
been
largely
described
using
transcriptomic
data.
Here,
we
introduce
a
proteomic
data
resource
and
Cellular
Indexing
of
Transcriptomes
Epitopes
by
Sequencing
panel
enhanced
with
antibodies
targeting
17
cell
surface
proteins
(mCITE-Seq).
We
evaluated
mCITE-Seq
on
HMC3
microglia-like
cells,
induced-pluripotent
stem
cell-derived
microglia
(iMG),
freshly
isolated
primary
human
microglia.
identified
novel
protein
markers
such
as
CD51
relate
expression
101
to
transcriptional
programs.
This
results
in
the
identification
validation
three
marker
combinations
which
purify
enriched
each
23
programs;
for
example,
CD49D,
HLA-DR
CD32
enrich
GPNMB
high
(“disease
associated”)
Further,
identify
validate
-
SIRPA,
PDPN
CD162
–
that
differentiate
from
infiltrating
macrophages.
The
enables
transition
RNA-based
classification
facilitates
functional
characterization
harmonization
model
systems.
Язык: Английский
IBA1, TMEM119, and CD206 in Glioblastoma: an Immunohistochemical Study exploring associations with Radiological Tumour Growth and Overall Survival
Research Square (Research Square),
Год журнала:
2025,
Номер
unknown
Опубликована: Май 7, 2025
Abstract
Purpose
Tumour-associated
macrophages
and
microglia
(TAMs)
are
important
components
of
the
glioblastoma
microenvironment.
These
cells
may
play
a
central
role
in
tumourigenesis
progression,
making
them
potential
targets
for
novel
therapies.
In
present
study
we
aimed
to
investigate
if
selected
putative
TAM
markers
related
radiological
speed
growth
overall
survival.
Methods
The
was
retrospectively
estimated
88
patients,
classified
into
faster-
slower-growing
groups
based
on
Gompertzian
model.
Tumour
samples
underwent
immunohistochemical
analyses
with
IBA1
(pan-macrophage
marker),
TMEM119
(microglia
marker)
CD206
(perivascular
recruited
macrophages)
their
associations
tumour
immunoreactivity
digitally
assessed
using
QuPath.
Associations
between
markers,
corticosteroids
were
Mann-Whitney
U-test.
Impact
survival
investigated
univariable
Cox
regression.
Correlations
Spearman’s
rank
correlation
test.
Results
We
found
no
significant
association
rate
or
significantly
correlated
there
higher
expressions
patient
group
treated
corticosteroids.
Conclusion
clear
evidence
that
expression
these
influences
our
patients.
Язык: Английский
Understanding brain cancer and exploiting its vulnerabilities
Molecular Oncology,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 25, 2024
Язык: Английский