Understanding brain cancer and exploiting its vulnerabilities DOI Creative Commons

Paolo Salomoni

Molecular Oncology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 25, 2024

Язык: Английский

Immunomodulatory mechanisms driving tumor escape in Glioblastoma: the central role of IDO and tryptophan metabolism in local and systemic immunotolerance DOI
Filippo Gagliardi, Pierfrancesco De Domenico,

Silvia Snider

и другие.

Critical Reviews in Oncology/Hematology, Год журнала: 2025, Номер unknown, С. 104657 - 104657

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

1

GBM immunotherapy: Exploring molecular and clinical frontiers DOI
Mrinal K. Ghosh,

Sunny Kumar,

Sabana Begam

и другие.

Life Sciences, Год журнала: 2024, Номер 356, С. 123018 - 123018

Опубликована: Авг. 28, 2024

Язык: Английский

Процитировано

7

A proteogenomic tool uncovers protein markers for human microglial states DOI
Philip L. De Jager, Verena Haage, Alex Bautista

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Май 2, 2025

Abstract Human microglial heterogeneity has been largely described using transcriptomic data. Here, we introduce a proteomic data resource and Cellular Indexing of Transcriptomes Epitopes by Sequencing panel enhanced with antibodies targeting 17 cell surface proteins (mCITE-Seq). We evaluated mCITE-Seq on HMC3 microglia-like cells, induced-pluripotent stem cell-derived microglia (iMG), freshly isolated primary human microglia. identified novel protein markers such as CD51 relate expression 101 to transcriptional programs. This results in the identification validation three marker combinations which purify enriched each 23 programs; for example, CD49D, HLA-DR CD32 enrich GPNMBhigh (“disease associated”) Further, identify validate - SIRPA, PDPN CD162 – that differentiate from infiltrating macrophages. The enables transition RNA-based classification facilitates functional characterization harmonization model systems.

Язык: Английский

Процитировано

0

IBA1, TMEM119, and CD206 in Glioblastoma: an Immunohistochemical Study exploring associations with Radiological Tumour Growth and Overall Survival DOI

Ida Kaalhus Nordahl,

Magnus Kvisten, Anne Line Stensjøen

и другие.

Research Square (Research Square), Год журнала: 2025, Номер unknown

Опубликована: Май 7, 2025

Abstract Purpose Tumour-associated macrophages and microglia (TAMs) are important components of the glioblastoma microenvironment. These cells may play a central role in tumourigenesis progression, making them potential targets for novel therapies. In present study we aimed to investigate if selected putative TAM markers related radiological speed growth overall survival. Methods The was retrospectively estimated 88 patients, classified into faster- slower-growing groups based on Gompertzian model. Tumour samples underwent immunohistochemical analyses with IBA1 (pan-macrophage marker), TMEM119 (microglia marker) CD206 (perivascular recruited macrophages) their associations tumour immunoreactivity digitally assessed using QuPath. Associations between markers, corticosteroids were Mann-Whitney U-test. Impact survival investigated univariable Cox regression. Correlations Spearman’s rank correlation test. Results We found no significant association rate or significantly correlated there higher expressions patient group treated corticosteroids. Conclusion clear evidence that expression these influences our patients.

Язык: Английский

Процитировано

0

Understanding brain cancer and exploiting its vulnerabilities DOI Creative Commons

Paolo Salomoni

Molecular Oncology, Год журнала: 2024, Номер unknown

Опубликована: Ноя. 25, 2024

Язык: Английский

Процитировано

1