Combined Bulk and Single-Cell Transcriptomic Analysis to Reveal the Potential Influences of Intestinal Inflammatory Disease on Multiple Sclerosis DOI Creative Commons
Xu Zhu, Junyu Zhu, Zhuo Ma

и другие.

Inflammation, Год журнала: 2024, Номер unknown

Опубликована: Дек. 16, 2024

Multiple sclerosis (MS) and inflammatory bowel disease (IBD) are both autoimmune disorders caused by dysregulated immune responses. Still, there is a growing awareness of the comorbidity between MS IBD. However, shared pathophysiological mechanisms these two diseases still lacking. RNA sequencing datasets (GSE126124, GSE9686, GSE36807, GSE21942) were analyzed to identify differential expressed genes (DEGs) for IBD experimental allergic encephalomyelitis (EAE). Other (GSE17048, GSE75214, GSE16879) downloaded further verification analysis. Shared pathways regulatory networks explored based on DEGs. The single-cell transcriptome central nervous system (CNS) cells sequenced from EAE brains public (PRJCA003980) characteristics Mass cytometry time-of-flight (CyTOF) peripheral blood mononuclear (PBMCs) was performed systematic response in model. Machine learning algorithms also used diagnostic biomarkers MS. We identified 74 common DEGs selected datasets, data intestinal tissues patients showed that 56 highly enriched IL1B+ macrophages. These DEGs, defined as inflammation-related (IRGs), pro-inflammatory macrophages mice patients. abundance CD14+ monocytes validated CyTOF data. IRGs response, NOD-like receptor signaling pathway, IL-18 other related pathways. In addition, 'AddModuleScore_UCell' analysis (such IL1B, S100A8, factors) mainly macrophages, which play an essential role activation multiple sclerosis, such IL-17 NF-kappa B TNF pathway. Finally, suppressors cytokine 3(SOCS3) formyl peptide 2(FPR2) potential machine learning. Two compared control, experiments revealed SOCS3 FPR2 samples. IRGs, encode cytokines, exhibit high expression levels may significant storm biomarkers, FPR2, screened out with great value

Язык: Английский

Gut-brain axis: A cutting-edge approach to target neurological disorders and potential synbiotic application DOI Creative Commons
Sumel Ashique, Sourav Mohanto, Mohammed Gulzar Ahmed

и другие.

Heliyon, Год журнала: 2024, Номер 10(13), С. e34092 - e34092

Опубликована: Июль 1, 2024

Язык: Английский

Процитировано

35
Inflammatory Bowel Disease and Neurodegenerative Diseases DOI Creative Commons
Jin Sun Kim, Mu‐Hong Chen, Hohui E. Wang

и другие.

Gut and Liver, Год журнала: 2023, Номер 17(4), С. 495 - 504

Опубликована: Фев. 27, 2023

A growing body of evidence has demonstrated an intricate association between inflammatory bowel disease (IBD) and neurodegenerative conditions, expanding beyond previous foci comorbidities IBD mood disorders.These new discoveries stem from improved understanding the gut-microbiome-brain axis: specifically, ability intestinal microbiota to modulate inflammation regulate neuromodulatory compounds.Clinical retrospective studies incorporating large sample sizes population-based cohorts have confirmed relevance chronic neurodegeneration in clinical medicine.In this review, we expound upon current knowledge on axis, highlighting several plausible mechanisms linking with neurodegeneration.We also summarize known associations Parkinson disease, Alzheimer vascular dementia ischemic stroke, multiple sclerosis a context.Finally, discuss implications axis preventing, diagnosing, managing among non-IBD patients.(

Язык: Английский

Процитировано

26
Lack of Causal Associations of Inflammatory Bowel Disease with Parkinson's Disease and Other Neurodegenerative Disorders DOI
Ruijie Zeng, Jinghua Wang, Chunwen Zheng

и другие.

Movement Disorders, Год журнала: 2023, Номер 38(6), С. 1082 - 1088

Опубликована: Март 23, 2023

Observational studies have indicated associations between inflammatory bowel disease (IBD) and neurodegenerative diseases, including Parkinson's (PD).To evaluate the causal of IBD with PD other selected disorders using updated data.Bidirectional two-sample Mendelian randomization genome-wide association summary statistics PD.We found a lack evidence for on (odds ratio [OR], 1.014; 95% confidence interval [CI], 0.967-1.063; P = 0.573). Reverse analysis also no effect (OR, 0.978; CI, 0.910-1.052; 0.549). The causality Alzheimer's disease, amyotrophic lateral sclerosis, multiple sclerosis was unfounded (all > 0.05).The analyses provide clear or three diseases. Potential confounders might contribute to previously observed associations, further investigations are warranted. © 2023 International Parkinson Movement Disorder Society.

Язык: Английский

Процитировано

22
Risk of Common Neurological Disorders in Adult Patients with Inflammatory Bowel Disease: A Systematic Review and Meta-analysis DOI
Mohammad Zamani, Forough Ebrahimtabar, Shaghayegh Alizadeh‐Tabari

и другие.

Inflammatory Bowel Diseases, Год журнала: 2024, Номер unknown

Опубликована: Янв. 25, 2024

Abstract Background Several studies investigated the risks of neurological conditions in patients with inflammatory bowel disease (IBD), some variability findings. We aimed to perform a systematic review and meta-analysis available evidence elucidate association between IBD common disorders. Methods conducted literature search through Embase, PubMed, Scopus, ProQuest databases from inception June 30, 2023, identify cohort assessing risk developing stroke, all-cause dementia, Parkinson’s (PD), multiple sclerosis (MS), seizure/epilepsy, peripheral neuropathy adult compared non-IBD population. combined hazard ratios (HRs) 95% confidence intervals (CIs) compute pooled estimates using random-effects model. Results In total, 22 were included, which 9 reported 7074 stroke events 202 460 patients, 5 3783 dementia diagnoses 109 602 7 932 PD 354 792 1 study 6 MS 35 581 patients. observed increased incident (pooled HR = 1.19; CI, 1.06-1.31), 1.22; 1.05-1.38), 1.39; 1.20-1.58), (HR 2.89; 1.02-8.42). No eligible found on seizure/epilepsy. Conclusions Inflammatory may be modestly associated PD. Further longitudinal are warranted investigate potential links MS, neuropathy, as well their clinical significance.

Язык: Английский

Процитировано

9
The gut–organ axis: Clinical aspects and immune mechanisms DOI Creative Commons

Nobuhiko FUKASAWA,

Junya Tsunoda,

Shogo Sunaga

и другие.

Allergology International, Год журнала: 2025, Номер unknown

Опубликована: Фев. 1, 2025

The gut-brain axis exemplifies the bidirectional connection between intestines and brain, as evidenced by impact of severe stress on gastrointestinal symptoms including abdominal pain diarrhea, conversely, influence discomfort mood. Clinical observations support notion connection, an increased prevalence inflammatory bowel disease (IBD) in patients with depression anxiety, well association changes gut microbiota neurological disorders such multiple sclerosis, Parkinson's disease, stroke Alzheimer's disease. brain communicate via complex mechanisms involving cytokines, immune cells, autonomic nerves, microbiota, which contribute to pathogenesis certain diseases. Two primary pathways mediate information exchange intestinal tract brain: signal transduction through bloodstream factors, bacterial metabolites neural pathways, neurotransmitters cytokines within nervous system interaction nerve cells beyond. In recent years, basic pathophysiology have been gradually elucidated. Beyond interaction, emerging evidence suggests extends other organs, liver lungs, intricate inter-organ communication pathways. An increasing number reports this clinical cross-organ interactions underscore potential for better understanding novel therapeutic strategies targeting inter-organs networks. Further clarification multiorgans premises transformative insights into strategies.

Язык: Английский

Процитировано

1
Inflammatory bowel disease and immune-mediated inflammatory diseases: looking at the less frequent associations DOI Creative Commons
Cristina Bezzio,

C. Della Corte,

Marta Vernero

и другие.

Therapeutic Advances in Gastroenterology, Год журнала: 2022, Номер 15

Опубликована: Янв. 1, 2022

Patients with inflammatory bowel disease (IBD) often have other immune-mediated diseases (IMIDs), and the prevalence of any IMID is higher in IBD patients than general population. IMIDs involve alterations innate adaptive immune responses. Their co-occurrence depends on shared processes, pathogenic mechanisms, genetic environmental risk factors, including drugs, especially tumor necrosis factor inhibitors. The more common associated been widely described, so this review focuses less frequent associations. discussed here are skin disorders (psoriasis, atopic dermatitis, vitiligo, epidermolysis bullosa acquisita, cutaneous polyarteritis nodosa, hidradenitis suppurativa), hepato-pancreatic (autoimmune hepatitis, granulomatous autoimmune pancreatitis), endocrine thyroid diseases, type 1 diabetes mellitus), multiple sclerosis, respiratory (asthma, bronchiectasis, interstitial pneumonia). early detection important to prevent their deleterious clinical course limit psychological impact. Care for should be multispecialist, a single therapeutic strategy instead treating each separately.

Язык: Английский

Процитировано

30
Impact of Microbiome–Brain Communication on Neuroinflammation and Neurodegeneration DOI Open Access

Iris Stolzer,

E Scherer, Patrick Süß

и другие.

International Journal of Molecular Sciences, Год журнала: 2023, Номер 24(19), С. 14925 - 14925

Опубликована: Окт. 5, 2023

The gut microbiome plays a pivotal role in maintaining human health, with numerous studies demonstrating that alterations microbial compositions can significantly affect the development and progression of various immune-mediated diseases affecting both digestive tract central nervous system (CNS). This complex interplay between microbiota, gut, CNS is referred to as gut-brain axis. microbiota pathogenesis neurodegenerative has gained increasing attention recent years, evidence suggests dysbiosis may contribute disease progression. Clinical have shown composition multiple sclerosis patients, decrease beneficial bacteria an increase pro-inflammatory bacteria. Furthermore, changes within community been linked Parkinson's Alzheimer's disease. Microbiota-gut-brain communication impact through mechanisms, including regulation immune function, production metabolites, well modulation host-derived soluble factors. review describes current literature on axis highlights novel systems allow cross-talk host might influence neuroinflammation neurodegeneration.

Язык: Английский

Процитировано

18
Anti-CD20 monoclonal antibody (mAb) therapy and colitis: A case series and review DOI

Sarah Tolaymat,

Kanika Sharma, Yusuf Kagzi

и другие.

Multiple Sclerosis and Related Disorders, Год журнала: 2023, Номер 75, С. 104763 - 104763

Опубликована: Май 15, 2023

Язык: Английский

Процитировано

13
From Skin and Gut to the Brain: The Infectious Journey of the Human Commensal Fungus Malassezia and Its Neurological Consequences DOI

Bharati Naik,

Jayaprakash Sasikumar, Shankar Das

и другие.

Molecular Neurobiology, Год журнала: 2024, Номер unknown

Опубликована: Июнь 14, 2024

Язык: Английский

Процитировано

5
Risk factors for inflammatory bowel disease: an umbrella review DOI Creative Commons

Tingping Wu,

Honghui Cheng,

Jiamei Zhuang

и другие.

Frontiers in Cellular and Infection Microbiology, Год журнала: 2025, Номер 14

Опубликована: Янв. 24, 2025

Introduction Inflammatory bowel disease (IBD) represents a cluster of chronic idiopathic inflammatory disorders situated at the nexus intricate interplays. The primary aim present investigation is to perform an umbrella review metaanalyses, systematically offering comprehensive overview evidence concerning risk factors for IBD. Methods To achieve this, we searched reputable databases, including PubMed, Embase, Web Science, and Cochrane Database Systematic Reviews, from inception through April 2023. Two authors independently assessed methodological quality each metaanalysis using AMSTAR tool adhered classification criteria. Results In total, extracted 191 unique in meta-analyses, 92 significantly associated factors. top ten were human cytomegalovirus (HCMV) infection, IBD family history, periodontal disease, poliomyelitis, campylobacter species hidradenitis suppurativa, psoriasis, use proton pump inhibitors, obstructive pulmonary western dietary pattern. Discussion conclusion, this 62 30 protective factors, most which related underlying diseases, personal lifestyle environmental findings paper help develop better prevention treatment measures reduce incidence IBD, delay its progression, burden IBD-related worldwide. registration https://www.crd.york.ac.uk/PROSPERO/ , identifier CRD42023417175.

Язык: Английский

Процитировано

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