Effect of Treatment on Steroidome in Women with Multiple Sclerosis
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(5), С. 1835 - 1835
Опубликована: Фев. 20, 2025
Multiple
sclerosis
(MS)
is
a
chronic
inflammatory
neurodegenerative
disease
of
the
central
nervous
system.
The
manifestation
MS
related
to
steroid
changes
during
menstrual
cycle
and
pregnancy.
As
data
focusing
on
effect
anti-MS
drug
treatment
steroidome
are
scarce,
we
evaluated
steroidomic
(79
steroids)
in
61
female
patients
reproductive
age
39
(29,
47)
years
(median
with
quartiles)
after
drugs
GC-MS/MS
platform
immunoassays
(cortisol
estradiol).
were
assessed
using
levels
molar
ratios
(SMRs)
that
may
reflect
activities
steroidogenic
enzymes
(SMRs).
A
repeated
measures
ANOVA,
followed
by
multiple
comparisons
OPLS
models,
used
for
statistical
analyses.
decreased
follicular
phase.
Anti-CD20
monoclonal
antibodies
(mAb),
such
as
ofatumumab
ocrelizumab;
inhibitors
sphingosine-1-phosphate
receptor
(S1PRI);
IFNβ-1a
circulating
17-hydroxy-pregnanes
shifted
CYP17A1
functioning
from
hydroxylase-
toward
lyase
step.
Decreased
conjugated/unconjugated
found
drugs,
especially
glatiramer
acetate
anti-CD20
mAb.
In
luteal
phase,
IFN-β1a
increased
steroidogenesis;
both
ocrelizumab
AKR1D1,
S1PRI
SRD5A
functioning.
mAb
reduced
catalyzing
synthesis
immunomodulatory
7α/β
16α-hydroxy-androgens,
which
affect
severity
MS.
above
findings
be
important
concerning
alterations
bioactive
steroids,
cortisol;
active
androgens
estrogens;
neuroactive,
neuroprotective,
steroids
terms
optimization
treatment.
Язык: Английский
Recent Advances in Metabolomics and Lipidomics Studies in Human and Animal Models of Multiple Sclerosis
Metabolites,
Год журнала:
2024,
Номер
14(10), С. 545 - 545
Опубликована: Окт. 13, 2024
Multiple
sclerosis
(MS)
is
a
neurodegenerative
and
inflammatory
disease
of
the
central
nervous
system
(CNS)
that
leads
to
loss
myelin.
There
are
three
main
types
MS:
relapsing-remitting
MS
(RRMS)
primary
secondary
progressive
(PPMS,
SPMS).
The
differentiation
in
pathogenesis
these
two
latter
courses
still
unclear.
underlying
mechanisms
yet
be
elucidated,
treatment
relies
on
immune-modifying
agents.
Recently,
lipidomics
metabolomics
studies
using
human
biofluids,
mainly
plasma
cerebrospinal
fluid
(CSF),
have
suggested
an
important
role
lipids
metabolites
pathophysiology
MS.
In
this
review,
results
from
analyses
performed
biological
samples
patients
MS-like
animal
models
presented
analyzed.
Based
collected
findings,
biochemical
pathways
cohorts
involved
were
investigated
potential
they
discussed.
Limitations
challenges
approaches
while
concluding
may
provide
more
holistic
approach
biomarkers
for
early
diagnosis
disease.
Язык: Английский