COVID-19 Breakthrough Infections in Immune-Mediated Inflammatory Diseases: Data from the SUCCEED (Safety and Immunogenicity of COVID-19 Vaccines in Systemic Autoimmune-Mediated Inflammatory Diseases) Study
Vaccines,
Год журнала:
2025,
Номер
13(2), С. 104 - 104
Опубликована: Янв. 22, 2025
Background:
The
Safety
and
Immunogenicity
of
COVID-19
Vaccines
in
Systemic
Autoimmune-Mediated
Inflammatory
Diseases
(SUCCEED)
study
was
created
to
better
understand
vaccination
immune-mediated
inflammatory
disease
(IMID).
Knowing
the
frequency
breakthrough
infections
is
important,
particularly
IMID.
Our
objective
assess
these
events
Methods:
We
prospectively
studied
IMID
participants
who
had
received
≥three
vaccine
doses.
Individuals
provided
saliva
samples
monthly
(September
2022
August
2023).
These
were
evaluated
by
polymerase
chain
reaction
(PCR)
for
SARS-CoV-2.
also
assessed
antibodies
against
SARS-CoV-2
(anti-spike,
SmT1,
receptor
binding
domain,
RBD,
nucleocapsid,
NP)
based
on
dried
blood
spots.
Multivariable
general
estimating
equation
regression
produced
odd
ratios
(OR)
PCR
positivity,
related
demographics,
immunosuppressives,
antibody
levels.
Results:
Diagnoses
included
rheumatoid
arthritis
RA
(N
=
161,
44%
total),
systemic
lupus,
psoriatic
arthritis,
spondylarthritis,
vasculitis,
sclerosis,
bowel
disease.
Of
366
participants,
most
taking
immunosuppressive
medication.
1266
samples,
56
(5.1%)
positive
PCR.
Higher
anti-SmT1
inversely
associated
with
detection
(adjusted
OR
0.66,
95%
confidence
interval
0.45–0.97).
Antibodies
NP
correlated
thus
could
not
be
a
single
model,
but
when
anti-RBD
used
place
anti-SmT1,
results
similar.
No
other
factor
(including
prior
infection)
clearly
detection.
Conclusions:
This
first
large
prospective
cohort
triple
(or
more)
vaccinated
individuals
IMIDs.
Anti-SmT1
appeared
protective
later
although
recent
past
infection
related.
suggests
importance
maintaining
robust
vaccine-induced
immunity
through
Язык: Английский
COVID-19 mortality amongst the immunosuppresed
Journal of Infection,
Год журнала:
2024,
Номер
88(4), С. 106137 - 106137
Опубликована: Март 11, 2024
Язык: Английский
COVID-19-Associated Sepsis: Potential Role of Phytochemicals as Functional Foods and Nutraceuticals
International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(15), С. 8481 - 8481
Опубликована: Авг. 3, 2024
The
acute
manifestations
of
coronavirus
disease
2019
(COVID-19)
exhibit
the
hallmarks
sepsis-associated
complications
that
reflect
multiple
organ
failure.
inflammatory
cytokine
storm
accompanied
by
an
imbalance
in
pro-inflammatory
and
anti-inflammatory
host
response
to
severe
respiratory
syndrome
2
(SARS-CoV-2)
infection
leads
critical
septic
shock.
sepsis
signature
severely
afflicted
COVID-19
patients
includes
cellular
reprogramming
dysfunction
high
mortality
rates,
emphasizing
importance
improved
clinical
care
advanced
therapeutic
interventions
for
associated
with
COVID-19.
Phytochemicals
functional
foods
nutraceutical
have
incredible
impact
on
healthcare
system,
which
prevention
and/or
treatment
chronic
diseases.
Hence,
present
review,
we
aim
explore
pathogenesis
disrupts
physiological
homeostasis
body,
resulting
damage.
Furthermore,
summarized
diverse
pharmacological
properties
some
potent
phytochemicals,
can
be
used
as
well
nutraceuticals
against
SARS-CoV-2
infection.
phytochemicals
explored
this
article
include
quercetin,
curcumin,
luteolin,
apigenin,
resveratrol,
naringenin,
are
major
phytoconstituents
our
daily
food
intake.
We
compiled
findings
from
various
studies,
including
trials
humans,
more
into
potential
each
phytochemical
COVID-19,
highlights
their
possible
pathogenesis.
conclude
review
will
open
a
new
research
avenue
exploring
phytochemical-derived
agents
preventing
or
treating
life-threatening
Язык: Английский