Cardiac Fibroblastic Niches in Homeostasis and Inflammation
Circulation Research,
Год журнала:
2024,
Номер
134(12), С. 1703 - 1717
Опубликована: Июнь 6, 2024
Fibroblasts
are
essential
for
building
and
maintaining
the
structural
integrity
of
all
organs.
Moreover,
fibroblasts
can
acquire
an
inflammatory
phenotype
to
accommodate
immune
cells
in
specific
niches
provide
migration,
differentiation,
growth
factors.
In
heart,
balancing
fibroblast
activity
is
critical
cardiac
homeostasis
optimal
organ
function
during
inflammation.
sustain
by
generating
local
niche
environments
that
support
housekeeping
functions
actively
engaging
intercellular
cross
talk.
During
perturbations,
rapidly
switch
state
communicate
with
infiltrating
orchestrate
cell
migration
activity.
Here,
we
summarize
current
knowledge
on
molecular
landscape
fibroblasts,
focusing
their
dual
role
promoting
tissue
modulating
cell–cardiomyocyte
interaction.
addition,
discuss
potential
future
avenues
manipulating
myocardial
Язык: Английский
The Role of Extracellular Vesicles in the Pathogenesis of Metabolic Dysfunction-Associated Steatotic Liver Disease and Other Liver Diseases
International Journal of Molecular Sciences,
Год журнала:
2025,
Номер
26(11), С. 5033 - 5033
Опубликована: Май 23, 2025
The
increasing
prevalence
of
liver
diseases,
such
as
metabolic
dysfunction-associated
steatotic
disease
(MASLD),
presents
considerable
medical
challenges,
particularly
given
the
absence
approved
pharmacological
treatments,
which
underscores
necessity
to
comprehend
its
underlying
mechanisms.
Extracellular
vesicles
(EVs),
are
tiny
particles
released
by
cells,
play
a
crucial
role
in
facilitating
communication
and
can
transport
harmful
molecules
that
promote
inflammation
tissue
damage.
These
EVs
involved
progression
various
types
disorders
since
they
aggravate
oxidative
stress.
Because
their
critical
role,
it
is
believed
widely
initiation
MASLD,
well
viral
hepatitis,
alcoholic
disease,
drug-induced
injury,
hepatocellular
carcinoma.
This
review
emphasizes
recent
findings
regarding
functions
above
pathologies
potential
new
therapeutic
targets,
paving
way
for
innovative
approaches
address
those
detrimental
conditions.
Язык: Английский
Impact of genetic background as a risk factor for atherosclerotic cardiovascular disease: A protocol for a nationwide genetic case-control (CV-GENES) study in Brazil
PLoS ONE,
Год журнала:
2024,
Номер
19(3), С. e0289439 - e0289439
Опубликована: Март 13, 2024
Atherosclerotic
Cardiovascular
Disease
(ASCVD)
represents
the
leading
cause
of
death
worldwide,
and
individual
screening
should
be
based
on
behavioral,
metabolic,
genetic
profile
derived
from
data
collected
in
large
population-based
studies.
Due
to
polygenic
nature
ASCVD,
we
aimed
assess
association
genomics
with
ASCVD
risk
its
impact
occurrence
acute
myocardial
infarction,
stroke,
or
peripheral
artery
thrombotic-ischemic
events
at
population
level.
CardioVascular
Genes
(CV-GENES)
is
a
nationwide,
multicenter,
1:1
case-control
study
3,734
patients
Brazil.
Inclusion
criterion
for
cases
first
one
events.
Individuals
without
known
will
eligible
as
controls.
A
core
lab
perform
analyses
through
low-pass
whole
genome
sequencing
exome
sequencing.
In
order
estimate
independent
between
polymorphisms
score
(PRS)
built
hybrid
approach
including
effect
size
each
Single
Nucleotide
Polymorphism
(SNP),
number
alleles
observed,
sample
ploidy,
total
SNPs
included
PRS,
non-missing
sample.
addition,
presence
pathogenic
likely
variants
screened
8
genes
(
ABCG5
,
ABCG8
APOB
APOE
LDLR
LDLRAP1
LIPA
PCSK9
)
associated
atherosclerosis.
Multiple
logistic
regression
applied
adjusted
odds
ratios
(OR)
95%
confidence
intervals
(CI),
attributable
risks
calculated.
Clinical
trial
registration:
This
registered
clinicaltrials.gov
NCT05515653
).
Язык: Английский
Aberrant DNA methylation associated with the development of metabolic dysfunction-associated fatty liver disease
CHILD`S HEALTH,
Год журнала:
2024,
Номер
19(4), С. 230 - 242
Опубликована: Июль 28, 2024
The
literature
review
deals
with
DNA
methylation,
a
key
epigenetic
mechanism
that
controls
the
activity
of
gene
transcription,
plays
decisive
role
in
formation
genomic
imprinting,
silencing,
X-chromosome
inactivation,
RNA
splicing,
repair,
cell
differentiation
and
reprogramming,
also
determines
occurrence
development
liver
steatotic
lesions
metabolic
disorders.
Methylation
cytosine
dinucleotide
(CpG)
can
be
represented
two
types:
de
novo
CpG
which
is
carried
out
by
5mC
writers
—
DNA-(cytosine-5)-methyltransferase
(DNMT)
3a
3b,
supporting
performed
DNMT1
during
replication.
It
has
been
found
maintenance
methylation
allows
preservation
pattern
characteristic
progenitor
cells
new
generation,
body
associated
its
increased
expression.
Active
demethylation
TET
dioxygenases,
including
three
enzymatic
representatives:
TET1,
TET2
TET3.
demonstrated
aberrant
nucleotides
directly
related
to
lipid
synthesis,
degree
oxidative
stress,
steatosis,
low-grade
inflammation,
insulin
resistance,
progression
fibrosis.
authors
presented
detail
functions
features
methyltransferases,
erasers,
readers
sites;
possible
violations
balance
erasers
DNA;
landscape
patterns;
clinical
significance
signatures
dysfunction-associated
fatty
disease.
Global
hypomethylation
genome,
at
least
55
genes,
observed
patients
emphasize
use
promising
direction
for
early
diagnosis
prognosis
course
disease,
while
study
molecular
components
mechanisms
involved
regulation
expression,
dependence
their
on
exposure
exposome
will
allow
personalize
improve
recommendations
lifestyle
diet
modification
Язык: Английский