Advancements in Wound Dressing Materials: Highlighting Recent Progress in Hydrogels, Foams, and Antimicrobial Dressings

Gels, Год журнала: 2025, Номер 11(2), С. 123 - 123

Опубликована: Фев. 7, 2025

Recent advancements in wound dressing materials have significantly improved acute and chronic management by addressing challenges such as infection control, moisture balance, enhanced healing. Important progress has been made, especially with hydrogels, foams, antimicrobial for creating optimized dressings. Hydrogels are known maintaining optimal levels, while foam dressings excellent exudate absorbents. Meanwhile, incorporates various agents to reduce risks. These options healing time focusing on customized patient needs. Therefore, this review highlights the newest research prototypes applications, emphasizing their particular benefits clinical importance. Innovations stimuli-responsive hydrogels hybrid bioengineered composites discussed relation properties, including responsiveness pH, temperature, glucose, or enzymes drug delivery precision. Moreover, ongoing trials included, demonstrating potential of emerging solutions be soon translated from laboratory settings. By discussing interdisciplinary approaches that integrate advanced materials, nanotechnology, biological insights, work provides a contemporary framework patient-centric, efficient care strategies.

Язык: Английский

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Development of Scalable Elastic Gelatin Hydrogel Films Crosslinked with Waterborne Polyurethane for Enhanced Mechanical Properties and Strain Recovery

Gels, Год журнала: 2025, Номер 11(1), С. 49 - 49

Опубликована: Янв. 8, 2025

Exploiting novel crosslinking chemistry, this study pioneers the use of waterborne polyurethane (WPU) to chemically crosslink porcine-derived gelatin, producing enhanced gelatin hydrogel films through a solvent-casting method. Our innovative approach harnesses reactive isocyanate groups WPU, coupling them effectively with gelatin's hydroxyl and primary amino form robust urea urethane linkages within matrix. This method not only preserves intrinsic elasticity but also significantly augments films' tensile strength strain. Comprehensive characterizations these pre-formed reaction mixtures were conducted using viscosity measurements, Fourier Transform Infrared Spectroscopy (FTIR), Thermogravimetric Analysis (TGA), universal testing machine (UTM) for tensile-recovery assessments, alongside evaluations their biocompatibility. The results demonstrated reduction in pore size an increase WPU concentration from 2 6% developed hydrogels decrease equilibrium swelling ratio 15% 9%, respectively. Further, exhibited highest stress both dry wet state. formed blend growth proliferation CCD-986K (fibroblast) CCD-1102 (keratinocyte) cells up 5 days co-culturing. indicate notable enhancement mechanical properties biocompatibility upon introduction positioning as superior candidates biomedical applications such tissue engineering wound dressing.

Язык: Английский

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Hydrogels and Microgels: Driving Revolutionary Innovations in Targeted Drug Delivery, Strengthening Infection Management, and Advancing Tissue Repair and Regeneration

Gels, Год журнала: 2025, Номер 11(3), С. 179 - 179

Опубликована: Март 3, 2025

Hydrogels and microgels are emerging as pivotal platforms in biomedicine, with significant potential targeted drug delivery, enhanced infection management, tissue repair regeneration. These gels, characterized by their high water content, unique structures, adaptable mechanical properties, interact seamlessly biological systems, making them invaluable for controlled release. In the realm of hydrogels can incorporate antimicrobial agents, offering robust defenses against bacterial infections. This capability is increasingly important fight antibiotic resistance, providing innovative solutions prevention wound dressings, surgical implants, medical devices. Additionally, biocompatibility customizable properties these gels make ideal scaffolds engineering, supporting growth damaged tissues. Despite promising applications, challenges such ensuring long-term stability, enhancing therapeutic agent loading capacities, scaling production must be addressed widespread adoption. review explores current advancements, opportunities, limitations microgels, highlighting research technological directions poised to revolutionize treatment strategies through personalized regenerative approaches.

Язык: Английский

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Hydrogel-Based Biointerfaces: Recent Advances, Challenges, and Future Directions in Human–Machine Integration

Gels, Год журнала: 2025, Номер 11(4), С. 232 - 232

Опубликована: Март 23, 2025

Human–machine interfacing (HMI) has emerged as a critical technology in healthcare, robotics, and wearable electronics, with hydrogels offering unique advantages multifunctional materials that seamlessly connect biological systems electronic devices. This review provides detailed examination of recent advancements hydrogel design, focusing on their properties potential applications HMI. We explore the key characteristics such biocompatibility, mechanical flexibility, responsiveness, which are essential for effective long-term integration tissues. Additionally, we highlight innovations conductive hydrogels, hybrid composite materials, fabrication techniques 3D/4D printing, allow customization to meet demands specific HMI applications. Further, discuss diverse classes polymers contribute conductivity, including conducting, natural, synthetic, polymers, emphasizing role enhancing electrical performance adaptability. In addition material examine regulatory landscape governing hydrogel-based biointerfaces applications, addressing considerations clinical translation commercialization. An analysis patent insights into emerging trends shaping future technologies human–machine interactions. The also covers range neural interfaces, soft haptic systems, where play transformative Thereafter, addresses challenges face issues related stability, scalability, while perspectives continued evolution technologies.

Язык: Английский

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Nanocellulose-hydrogel hybrids: A review on synthesis and applications in agriculture, food packaging and water remediation

International Journal of Biological Macromolecules, Год журнала: 2025, Номер unknown, С. 143081 - 143081

Опубликована: Апрель 1, 2025

Язык: Английский

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Biomimetic Hydrogels from Mixed Gellan Gum and Tryptophan Zipper Self-Assembling Peptides

ACS Macro Letters, Год журнала: 2025, Номер unknown, С. 679 - 686

Опубликована: Май 9, 2025

Peptide self-assembly has been used to fabricate synthetic hydrogels that emulate many of the chemical and physical properties natural hydrogels. However, these materials often lack stability for applications do not display native bioactivity found in tissue. Here we demonstrate a hybrid hydrogel system which self-assembling peptides are integrated with polysaccharides enhance gelation provide improved mechanics bioactivity. A peptide based on tryptophan zipper (trpzip) motif was mixed anionic polysaccharide gellan gum, demonstrating within minutes increased stiffness compared trpzip alone. The material maintained viscoelastic character shear-thinning, self-healing, stress-relaxation order like collagen. All supported cell adhesion viability gum content, promoting assembly into aggregates. enhanced kinetics, stability, make them promising candidates as matrices culture reagents biofabrication syringe extrusion biological delivery.

Язык: Английский

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Additive Manufacturing of Soft Materials and Soft Gel for Bio-organs

Springer tracts in additive manufacturing, Год журнала: 2025, Номер unknown, С. 443 - 473

Опубликована: Янв. 1, 2025

Язык: Английский

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