Advanced Functional Materials,
Год журнала:
2018,
Номер
28(22)
Опубликована: Апрель 16, 2018
Abstract
Nanomaterials
with
high
biocompatibility
and
efficient
photothermal
conversion
have
drawn
tremendous
attention
for
tumor
diagnosis
treatment.
In
this
study,
spiky
Fe
3
O
4
@Au
supraparticles
(SPs)
are
used
as
phototherapy
multimodal
imaging
agents.
The
SPs
show
excellent
photodynamic
therapeutic
effects,
a
efficiency
of
31%,
allow
tumor‐targeted
imaging,
including
computed
tomographic,
photoacoustic,
magnetic
resonance
imaging.
both
in
vitro
vivo.
Furthermore,
because
their
remarkable
absorption
at
near‐infrared
region,
the
obliterate
under
808
nm
irradiation.
With
capacity
highly
integrated
multiple
functions,
promising
agent
application
to
clinical
practice.
Abstract
Glucose
oxidase
(GOx)
can
react
with
intracellular
glucose
and
oxygen
(O
2
)
to
produce
hydrogen
peroxide
(H
O
gluconic
acid,
which
cut
off
the
nutrition
source
of
cancer
cells
consequently
inhibit
their
proliferation.
Therefore,
GOx
is
recognised
as
an
ideal
endogenous
oxido‐reductase
for
starvation
therapy.
This
process
further
regulate
tumor
microenvironment
by
increasing
hypoxia
acidity.
Thus,
offers
new
possibilities
elaborate
design
multifunctional
nanocomposites
However,
natural
expensive
prepare
purify
exhibits
immunogenicity,
short
in
vivo
half‐life,
systemic
toxicity.
Furthermore,
highly
prone
degrade
after
exposure
biological
conditions.
These
intrinsic
shortcomings
will
undoubtedly
limit
its
biomedical
applications.
Accordingly,
some
nanocarriers
be
used
protect
from
surrounding
environment,
thus
controlling
or
preserving
activity.
A
variety
including
hollow
mesoporous
silica
nanoparticles,
metal–organic
frameworks,
organic
polymers,
magnetic
nanoparticles
are
summarized
construction
GOx‐based
multimodal
synergistic
In
addition,
current
challenges
promising
developments
this
area
highlighted.
ACS Nano,
Год журнала:
2017,
Номер
11(6), С. 5633 - 5645
Опубликована: Май 19, 2017
Nanoscale
ternary
chalcogenides
have
attracted
intense
research
interest
due
to
their
wealth
of
tunable
properties
and
diverse
applications
in
energy
environmental
biomedical
fields.
In
this
article,
ultrasmall
magnetic
CuFeSe2
nanocrystals
(<5.0
nm)
were
fabricated
the
presence
thiol-functionalized
poly(methacrylic
acid)
by
an
environmentally
friendly
aqueous
method
under
ambient
conditions.
The
small
band
gap
existence
intermediate
bands
lead
a
broad
NIR
absorbance
range
500–1100
nm
high
photothermal
conversion
efficiency
(82%)
nanocrystals.
resultant
show
superparamagnetism
effective
attenuation
for
X-rays.
addition,
they
also
exhibit
excellent
water
solubility,
colloidal
stability,
biocompatibility,
multifunctional
groups.
These
enable
them
be
ideal
nanotheranostic
agent
multimodal
imaging
[e.g.,
photoacoustic
(PAI),
resonance
(MRI),
computed
tomography
(CT)
imaging]
guided
therapy
cancer.
ACS Nano,
Год журнала:
2018,
Номер
12(3), С. 2695 - 2707
Опубликована: Март 8, 2018
The
treatment
of
melanoma
requires
complete
removal
tumor
cells
and
simultaneous
tissue
regeneration
tumor-initiated
cutaneous
defects.
Herein,
copper
silicate
hollow
microspheres
(CSO
HMSs)-incorporated
bioactive
scaffolds
were
designed
for
chemo-photothermal
therapy
skin
cancers
tissue.
CSO
HMSs
synthesized
with
interior
external
nanoneedle
microstructure,
showing
excellent
drug-loading
capacity
photothermal
effects.
With
incorporation
drug-loaded
into
the
electrospun
scaffolds,
composite
exhibited
effects
controlled
NIR-triggered
drug
release,
leading
to
distinctly
synergistic
cancer
both
in
vitro
vivo.
Furthermore,
such
HMSs-incorporated
could
promote
proliferation
attachment
normal
accelerate
healing
tumor-bearing
diabetic
mice.
Taken
together,
may
be
used
eradication
remaining
after
surgery
healing,
which
offers
an
effective
strategy
ACS Applied Nano Materials,
Год журнала:
2021,
Номер
4(11), С. 11353 - 11385
Опубликована: Ноя. 16, 2021
Photothermal
therapy
(PTT)
is
recognized
as
a
promising
approach
for
cancer
theranostics
via
the
nonradiative
conversion
of
light
into
heat
energy.
PTT
treatment
able
to
reduce
adverse
side
effects
traditional
chemotherapy.
Some
nanomaterials
functionalized
with
unique
physical
and
chemical
properties
have
been
integrated
multiple
imaging
modalities
therapeutic
function
applications.
In
past
decade,
various
applications
reviewed,
but
comprehensive
survey
all
classes
photothermal
developed
in
recent
years
has
not
done.
A
discussion
mechanisms
using
different
their
application
combination
useful
providing
insights
material
development
disease
future.
this
review,
advancement
excellence
combined
therapies
field
anticancer
are
discussed.
The
momentous
property
tailored
advancing
noninvasive
also
highlighted.
Because
great
deal
decades
reviewed
years,
we
only
include
latest
results
reported
5
comparison.
Chemical Reviews,
Год журнала:
2022,
Номер
122(6), С. 5411 - 5475
Опубликована: Янв. 11, 2022
In
recent
years,
the
continuous
development
of
magnetic
nanostructures
(MNSs)
has
tremendously
promoted
both
fundamental
scientific
research
and
technological
applications.
Different
from
bulk
magnet,
systematic
engineering
on
MNSs
brought
a
great
breakthrough
in
some
emerging
fields
such
as
construction
MNSs,
magnetism
exploration
multidimensional
their
potential
translational
this
review,
we
give
detailed
description
synthetic
strategies
based
features
application
discuss
progress
nanomedicines,
advanced
nanobiotechnology,
catalysis,
electromagnetic
wave
adsorption
(EMWA),
aiming
to
provide
guidance
for
fabrication
toward
diverse
ACS Nano,
Год журнала:
2018,
Номер
12(7), С. 6806 - 6818
Опубликована: Июль 2, 2018
Breast
cancer
therapy
has
always
been
a
hard
but
urgent
issue.
Disruption
of
mitochondrial
Ca2+
homeostasis
reported
as
an
effective
antitumor
strategy,
while
how
to
contribute
overload
effectively
is
critical
To
solve
this
issue,
we
designed
and
engineered
dual
enhanced
nanogenerator
(DECaNG),
which
can
induce
elevation
intracellular
through
the
following
three
ways:
Calcium
phosphate
(CaP)-doped
hollow
mesoporous
copper
sulfide
was
basic
generate
directly
persistently
in
lysosomes
(low
pH).
Near-infrared
light
radiation
(NIR,
such
808
nm
laser)
accelerate
generation
from
by
disturbing
crystal
lattice
via
NIR-induced
heat.
Curcumin
facilitate
release
endoplasmic
reticulum
cytoplasm
inhibit
expelling
cytoplasmic
membrane.
The
vitro
study
showed
that
DECaNG
could
produce
large
amount
flow
mitochondria,
leading
upregulation
Caspase-3,
cytochrome
c,
downregulation
Bcl-2
ATP
followed
cell
apoptosis.
In
addition,
had
outstanding
photothermal
effect.
Interestingly,
it
found
exerted
stronger
effect
at
lower
pH
due
super
small
nanoparticles
effect,
thus
enhancing
therapy.
vivo
study,
nanoplatform
good
tumor
targeting
treatment
efficacy
combination
disruption
metabolism
CaNG
sped
up
disintegration
into
smaller
nanoparticles,
reducing
retention
time
vivo.
Therefore,
be
promising
drug
delivery
system
for
breast
Nanoscale,
Год журнала:
2018,
Номер
10(29), С. 14304 - 14313
Опубликована: Янв. 1, 2018
CuCo2S4
nanosheets
on
carbon
fiber
textile
were
synthesized
by
a
one-step
hydrothermal
procedure
for
high-performance
supercapacitors
and
non-enzymatic
glucose
sensors.
Transition
metal
dichalcogenides
(TMDs)
have
received
considerable
attention
due
to
their
strong
absorption
in
the
near-infrared
(NIR)
region,
spin-orbit
coupling,
and
excellent
photothermal
conversion
efficiency
(PCE).
Herein,
CoFeMn
dichalcogenide
nanosheets
(CFMS
NSs)
are
prepared
via
facile
vulcanization
of
a
lamellar
CoFeMn-layered
double
hydroxide
(LDH)
precursor
followed
by
polyvinyl
pyrrolidone
modification
(to
give
CFMS-PVP
NSs),
found
show
photoacoustic
(PA)
imaging
synergistic
photothermal/chemodynamic
therapy
(PTT/CDT)
performance.
The
as-prepared
NSs
inherit
ultrathin
morphology
CoFeMn-LDH
exhibit
an
outstanding
performance
with
η
89.0%,
highest
PCE
reported
date
for
2D
TMD
materials.
Moreover,
50%
maximum
catalytic
activity
(Michaelis-Menten
constant,
Km)
is
attained
0.26
×
10-3
m
H2O2
at
318
K,
markedly
lower
than
endogenous
concentration
inside
tumor
cells.
In
addition,
complete
apoptosis
HepG2
cancer
cells
elimination
vivo
observed
after
treatment
low
dose,
substantiating
NSs'
remarkable
PTT/CDT
efficacy.
This
work
provides
new
approach
synthesis
high-quality
multicomponent
precise
process
control,
potential
mass
production,
performance,
providing
great
promise
theranostics.
