Photothermal Nanomaterials: A Powerful Light-to-Heat Converter

Chemical Reviews, Год журнала: 2023, Номер 123(11), С. 6891 - 6952

Опубликована: Май 3, 2023

All forms of energy follow the law conservation energy, by which they can be neither created nor destroyed. Light-to-heat conversion as a traditional yet constantly evolving means converting light into thermal has been enduring appeal to researchers and public. With continuous development advanced nanotechnologies, variety photothermal nanomaterials have endowed with excellent harvesting capabilities for exploring fascinating prospective applications. Herein we review latest progresses on nanomaterials, focus their underlying mechanisms powerful light-to-heat converters. We present an extensive catalogue nanostructured materials, including metallic/semiconductor structures, carbon organic polymers, two-dimensional materials. The proper material selection rational structural design improving performance are then discussed. also provide representative overview techniques probing photothermally generated heat at nanoscale. finally recent significant developments applications give brief outlook current challenges future directions nanomaterials.

Язык: Английский

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Multifunctional Photoactive Hydrogels for Wound Healing Acceleration

ACS Nano, Год журнала: 2021, Номер 15(12), С. 18895 - 18930

Опубликована: Дек. 6, 2021

Light is an attractive tool that has a profound impact on modern medicine. Particularly, light-based photothermal therapy (PTT) and photodynamic (PDT) show great application prospects in the prevention of wound infection promoting healing. In addition, hydrogels have shown advantages field dressings due to their excellent biochemical effects. Therefore, multifunctional photoresponsive (MPRHs) integrate light are increasingly used biomedicine, especially repair. However, comprehensive review MPRHs for regeneration still lacking. This first focuses various types prepared by diverse photosensitizers, agents (PHTAs) including transition metal sulfide/oxides nanomaterials, nanostructure-based PHTAs, carbon-based conjugated polymer or complex-based and/or (PHDAs) such as ZnO-based, black-phosphorus-based, TiO2-based, small organic molecule-based PHDAs. We also then discuss how PTT, PDT, photothermal/photodynamic synergistic can modulate microenvironments bacteria inhibit infection. Overall, with both therapeutic tissue capabilities been discussed existing challenges, well future research directions management argued.

Язык: Английский

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Aggregation behaviour of pyrene-based luminescent materials, from molecular design and optical properties to application

Chemical Society Reviews, Год журнала: 2023, Номер 52(19), С. 6715 - 6753

Опубликована: Янв. 1, 2023

This review not only highlights the progress of emission and electronic behaviour new pyrene-based luminescence molecules in aggregated state, but also provides a perspective for understanding mechanism optoelectronic properties pyrenes.

Язык: Английский

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Targeting drug delivery with light: A highly focused approach

Advanced Drug Delivery Reviews, Год журнала: 2021, Номер 171, С. 94 - 107

Опубликована: Янв. 22, 2021

Язык: Английский

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Spatiotemporal control of CRISPR/Cas9 gene editing

Signal Transduction and Targeted Therapy, Год журнала: 2021, Номер 6(1)

Опубликована: Июнь 20, 2021

Abstract The clustered regularly interspaced short palindromic repeats (CRISPR)/associated protein 9 (CRISPR/Cas9) gene editing technology, as a revolutionary breakthrough in genetic engineering, offers promising platform to improve the treatment of various and infectious diseases because its simple design powerful ability edit different loci simultaneously. However, failure conduct precise specific tissues or cells within certain time may result undesirable consequences, such serious off-target effects, representing critical challenge for clinical translation technology. Recently, some emerging strategies using regulation, chemical physical regulate activity CRISPR/Cas9 have shown results improvement spatiotemporal controllability. Herein, this review, we first summarize latest progress these advanced involving cell-specific promoters, small-molecule activation inhibition, bioresponsive delivery carriers, optical/thermal/ultrasonic/magnetic activation. Next, highlight advantages disadvantages discuss their obstacles limitations translation. Finally, propose viewpoints on directions that can be explored further operability CRISPR/Cas9.

Язык: Английский

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Rational Design in Photopharmacology with Molecular Photoswitches

Angewandte Chemie International Edition, Год журнала: 2023, Номер 62(30)

Опубликована: Апрель 7, 2023

Photopharmacology is an attractive approach for achieving targeted drug action with the use of light. In photopharmacology, molecular photoswitches are introduced into structure biologically active small molecules to allow optical control their potency. Going beyond trial and error, photopharmacology has progressively applied rational design methodologies devise light-controlled bioactive ligands. this review, we categorize photopharmacological efforts from standpoint medicinal chemistry strategies, focusing on diffusible photochromic ligands modified that operate through E-Z bond isomerization. vast majority cases, photoswitchable designed as analogs existing compounds, a variety approaches. By analyzing in detail comprehensive list instructive examples, describe state art discuss future opportunities photopharmacology.

Язык: Английский

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Near‐Infrared Light‐Activatable Dual‐Action Nanoparticle Combats the Established Biofilms of Methicillin‐Resistant Staphylococcus aureus and Its Accompanying Inflammation

Small, Год журнала: 2021, Номер 17(13)

Опубликована: Март 10, 2021

Abstract Clinically, inhibition of both bacterial infection and excessive inflammation is a crucial step for improved wound treatments. Herein, the fabrication near‐infrared‐light (NIR)‐activatable deoxyribonuclease (DNase)–carbon monoxide (CO)@mesoporous polydopamine nanoparticles (MPDA NPs) demonstrated efficient elimination methicillin‐resistant Staphylococcus aureus (MRSA) biofilms following anti‐inflammatory activity. Specifically, thermosensitive CO‐gas‐releasing donors (CO releasing molecules, FeCO) are first encapsulated into MPDA NPs, followed by covalently immobilizing I (DNase I) on surfaces NPs. DNase can degrade extracellular DNA in biofilms, which site specifically destroys compactness biofilms. With NIR irradiation, DNase–CO@MPDA NPs display great photothermal ability, further trigger on‐demand delivery bactericidal CO gas that adequately permeate impaired Eventually, they achieve effective MRSA biofilm virtue synergistic effects participation CO‐gas‐potentiated therapy. Importantly, inflammatory responses NIR‐treated wounds simultaneously alleviated owing to features released CO. Finally, NIR‐activatable accelerate healing process MRSA‐biofilm‐infected cutaneous wounds. Taken together, this phototherapeutic strategy displays therapeutic potential treating formidable clinical problems caused accompanying inflammation.

Язык: Английский

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Nanocarrier cancer therapeutics with functional stimuli-responsive mechanisms

Journal of Nanobiotechnology, Год журнала: 2022, Номер 20(1)

Опубликована: Март 24, 2022

Presently, nanocarriers (NCs) have gained huge attention for their structural ability, good biocompatibility, and biodegradability. The development of effective NCs with stimuli-responsive properties has acquired a interest among scientists. When developing drug delivery NCs, the fundamental goal is to tackle delivery-related problems associated standard chemotherapy carry medicines intended sites action while avoiding undesirable side effects. These were able delivering drugs tumors through regulating pH, temperature, enzyme responsiveness. With use nanocarriers, chemotherapeutic could be supplied more accurately that can equally encapsulate deliver them. Material carriers are discussed in this review keeping viewpoint targeting methods make these therapeutically effective, addition metabolic pathways triggered by drug-loaded NCs. Largely, countering endogenous exogenous stimuli tumor regions understanding mechanisms would encourage progress therapy precision diagnosis future.

Язык: Английский

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Photon-Controlled Pyroptosis Activation (PhotoPyro): An Emerging Trigger for Antitumor Immune Response

Journal of the American Chemical Society, Год журнала: 2023, Номер 145(11), С. 6007 - 6023

Опубликована: Март 7, 2023

Pyroptosis refers to the process of gasdermin-mediated lytic programmed cell death (PCD) characterized by release pro-inflammatory cytokines. Our knowledge pyroptosis has expanded beyond cellular level and now includes extracellular responses. In recent years, attracted considerable attention due its potential induce host immunity. For instance, at 2022 International Medicinal Chemistry Natural Active Ligand Metal-Based Drugs (MCNALMD) conference, numerous researchers demonstrated an interest in photon-controlled activation ("PhotoPyro"), emerging pyroptosis-engineered approach for activating systemic immunity via photoirradiation. Given this enthusiasm, we share Perspective our views on area expound how why "PhotoPyro" could trigger antitumor (i.e., turning so-called "cold" tumors "hot"). doing so, have tried highlight cutting-edge breakthroughs PhotoPyro while suggesting areas future contributions. By providing insights into current state art serving as a resource individuals interested working area, it is hoped that will set stage evolve broadly applicable cancer treatment strategy.

Язык: Английский

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Light responsive hydrogels for controlled drug delivery

Frontiers in Bioengineering and Biotechnology, Год журнала: 2022, Номер 10

Опубликована: Дек. 16, 2022

Light is an easy acquired, effective and non-invasive external stimulus with great flexibility focusability. Thus, light responsive hydrogels are of particular interests to researchers in developing accurate controlled drug delivery systems. obtained by incorporating photosensitive moieties into their polymeric structures. Drug release can be realized through three major mechanisms: photoisomerization, photochemical reaction photothermal reaction. Recent advances material science have resulted development photosensitizers, such as rare metal nanostructures black phosphorus nanoparticles, order respond a variety sources. Hydrogels incorporated photosensitizers crucial for clinical applications, the use ultraviolet near-infrared well up-conversion nanoparticles has greatly increased therapeutic effects. Existing systems been utilized delivering drugs, proteins genes chemotherapy, immunotherapy, photodynamic therapy, gene wound healing other applications. Principles associated site-specific targeting, metabolism, toxicity used optimize efficacy safety, improve patient compliance convenience. In view importance this field, we review current development, challenges future perspectives delivery.

Язык: Английский

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