Chemical Reviews,
Год журнала:
2022,
Номер
123(2), С. 834 - 873
Опубликована: Авг. 5, 2022
Biomaterials
with
the
ability
to
self-heal
and
recover
their
structural
integrity
offer
many
advantages
for
applications
in
biomedicine.
The
past
decade
has
witnessed
rapid
emergence
of
a
new
class
self-healing
biomaterials
commonly
termed
injectable,
or
printable
context
3D
printing.
These
injectable
biomaterials,
mostly
hydrogels
other
soft
condensed
matter
based
on
reversible
chemistry,
are
able
temporarily
fluidize
under
shear
stress
subsequently
original
mechanical
properties.
Self-healing
distinct
compared
traditional
biomaterials.
Most
notably,
they
can
be
administered
locally
targeted
minimally
invasive
manner
through
narrow
syringe
without
need
surgery.
Their
moldability
allows
patient-specific
intervention
shows
great
prospects
personalized
medicine.
Injected
facilitate
tissue
regeneration
multiple
ways
owing
viscoelastic
diffusive
nature,
ranging
from
simple
support,
spatiotemporally
controlled
delivery
cells
therapeutics,
local
recruitment
modulation
host
promote
regeneration.
Consequently,
have
been
at
forefront
cutting-edge
strategies.
This
study
provides
critical
review
current
state
As
key
challenges
toward
further
maturation
this
exciting
research
field,
we
identify
(i)
trade-off
between
injectability
vs
physical
stability,
(ii)
lack
consensus
rheological
characterization
quantitative
benchmarks
hydrogels,
particularly
regarding
capillary
flow
syringes,
(iii)
practical
limitations
translation
therapeutically
effective
formulations
specific
tissues.
Hence,
here
chemical
design
strategies
provide
guide
analysis,
showcase
applicability
various
tissues
printing
complex
organoids.
ACS Nano,
Год журнала:
2021,
Номер
15(12), С. 18895 - 18930
Опубликована: Дек. 6, 2021
Light
is
an
attractive
tool
that
has
a
profound
impact
on
modern
medicine.
Particularly,
light-based
photothermal
therapy
(PTT)
and
photodynamic
(PDT)
show
great
application
prospects
in
the
prevention
of
wound
infection
promoting
healing.
In
addition,
hydrogels
have
shown
advantages
field
dressings
due
to
their
excellent
biochemical
effects.
Therefore,
multifunctional
photoresponsive
(MPRHs)
integrate
light
are
increasingly
used
biomedicine,
especially
repair.
However,
comprehensive
review
MPRHs
for
regeneration
still
lacking.
This
first
focuses
various
types
prepared
by
diverse
photosensitizers,
agents
(PHTAs)
including
transition
metal
sulfide/oxides
nanomaterials,
nanostructure-based
PHTAs,
carbon-based
conjugated
polymer
or
complex-based
and/or
(PHDAs)
such
as
ZnO-based,
black-phosphorus-based,
TiO2-based,
small
organic
molecule-based
PHDAs.
We
also
then
discuss
how
PTT,
PDT,
photothermal/photodynamic
synergistic
can
modulate
microenvironments
bacteria
inhibit
infection.
Overall,
with
both
therapeutic
tissue
capabilities
been
discussed
existing
challenges,
well
future
research
directions
management
argued.
ACS Nano,
Год журнала:
2022,
Номер
16(8), С. 13022 - 13036
Опубликована: Авг. 3, 2022
Burns
are
a
common
health
problem
worldwide
and
highly
susceptible
to
bacterial
infections
that
difficult
handle
with
ordinary
wound
dressings.
Therefore,
burn
repair
is
extremely
challenging
in
clinical
practice.
Herein,
series
of
self-healing
hydrogels
(QCS/OD/TOB/PPY@PDA)
good
electrical
conductivity
antioxidant
activity
were
prepared
on
the
basis
quaternized
chitosan
(QCS),
oxidized
dextran
(OD),
tobramycin
(TOB),
polydopamine-coated
polypyrrole
nanowires
(PPY@PDA
NWs).
These
Schiff
base
cross-links
between
aminoglycoside
antibiotic
TOB
OD
enable
be
slowly
released
responsive
pH.
Interestingly,
acidic
substances
during
bacteria
growth
process
can
induce
on-demand
release
TOB,
avoiding
abuse
antibiotics.
The
antibacterial
results
showed
QCS/OD/TOB/PPY@PDA9
hydrogel
could
kill
high
concentrations
Pseudomonas
aeruginosa
(PA),
Staphylococcus
aureus,
Escherichia
coli
short
time
bactericidal
effect
for
up
11
days
an
agar
plate
diffusion
experiment,
while
showing
vivo
activity.
Excellent
long-lasting
properties
make
it
suitable
severely
infected
wounds.
Furthermore,
incorporation
PPY@PDA
endowed
near-infrared
(NIR)
irradiation
assisted
drug-resistant
bacteria,
conductivity,
Most
importantly,
PA-infected
model,
more
effectively
controlled
inflammation
levels
promoted
collagen
deposition,
vascular
generation,
earlier
closure
compared
Tegaderm
smart
delivery
advantageous
bacterial-infected
healing.
Bioactive Materials,
Год журнала:
2022,
Номер
24, С. 197 - 235
Опубликована: Дек. 23, 2022
Chronic
wounds
have
become
one
of
the
most
important
issues
for
healthcare
systems
and
are
a
leading
cause
death
worldwide.
Wound
dressings
necessary
to
facilitate
wound
treatment.
Engineering
may
substantially
reduce
healing
time,
risk
recurrent
infections,
disability
costs
associated.
In
path
engineering
an
ideal
dressing,
hydrogels
played
role.
Hydrogels
3D
hydrophilic
polymeric
structures
that
can
provide
protective
barrier,
mimic
native
extracellular
matrix
(ECM),
humid
environment.
Due
their
advantages,
(with
different
architectural,
physical,
mechanical,
biological
properties)
been
extensively
explored
as
dressing
platforms.
Here
we
describe
recent
studies
on
applications
with
strong
focus
interplay
between
fabrication
method
used
performance
achieved.
Moreover,
review
categories
additives
which
enhance
regeneration
using
hydrogel
dressings.
Hydrogel
promises
generation
smart
solutions
solve
this
pressing
problem,
enabling
key
functionalities
such
bacterial
growth
inhibition,
enhanced
re-epithelialization,
vascularization,
improved
recovery
tissue
functionality,
overall,
accelerated
effective
healing.
Nano-Micro Letters,
Год журнала:
2022,
Номер
14(1)
Опубликована: Сен. 13, 2022
Hydrogels
with
multifunctionalities,
including
sufficient
bonding
strength,
injectability
and
self-healing
capacity,
responsive-adhesive
ability,
fault-tolerant
repeated
tissue
adhesion,
are
urgently
demanded
for
invasive
wound
closure
healing.
Motivated
by
the
adhesive
mechanism
of
mussel
brown
algae,
bioinspired
dynamic
bonds
cross-linked
multifunctional
hydrogel
is
designed
based
on
sodium
alginate
(SA),
gelatin
(GT)
protocatechualdehyde,
ferric
ions
added,
sutureless
post-wound-closure.
The
through
Schiff
base
bond,
catechol-Fe
coordinate
bond
strong
interaction
between
GT
temperature-dependent
phase
transition
SA,
endows
resulting
mechanical
strength
efficient
closure,
reopened
wounds.
Moreover,
properties
endowed
mispositioning
to
be
removed/repositioned,
which
conducive
adhesion
adhesives
during
surgery.
Besides,
hydrogels
present
good
biocompatibility,
near-infrared-assisted
photothermal
antibacterial
activity,
antioxidation
thermo-responsive
reversible
hemostatic
effect.
in
vivo
incision
evaluation
demonstrated
their
capability
promote
post-wound-closure
healing
incisions,
indicating
that
developed
dressing
could
serve
as
versatile
sealant.
Advanced Functional Materials,
Год журнала:
2022,
Номер
32(47)
Опубликована: Сен. 17, 2022
Abstract
Flexible
epidermic
sensors
made
from
conductive
hydrogels
are
holding
bright
potential
in
personalized
healthcare,
multifunctional
electronic
skins,
and
human‐machine
interfaces.
However,
it
is
still
a
great
challenge
to
simultaneously
realize
hydrogel‐based
with
reliable
self‐healing
ability
remarkable
sensing
performances
high‐performance
healthcare
(especially
electrophysiological
signals)
for
wearable
interaction,
as
well
accelerated
wound
healing
subsequent
medical
treatment
together.
Herein,
flexible
healable
sensor
assembled
the
facilely
prepared
antibacterial
MXene
hydrogel
efficiently
sensitively
interaction.
The
as‐prepared
possesses
enhanced
mechanical
performance,
outstanding
capability,
injectability,
facile
degradability,
excellent
biocompatibility,
robust
ability,
which
capable
of
being
into
monitor
human
movements
rehabilitation
training,
detect
tiny
signals
diagnosis
cardiovascular‐
muscle‐related
diseases,
be
employed
In
addition,
can
utilized
treat
infection
effectively
accelerate
healing.
Thus,
sheds
light
on
preparing
integration
personal
health
smart
interaction
next‐generation
artificial
skins.
