International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 3737 - 3751
Опубликована: Апрель 1, 2024
Chemo-photodynamic
combination
therapy
has
demonstrated
significant
potential
in
the
treatment
of
cancer.
Triptolide
(TPL),
a
naturally
derived
anticancer
agent,
when
combined
with
photosensitizer
Chlorin
e6
(Ce6),
shown
to
provide
enhanced
anti-tumor
benefits.
However,
development
stimuli-responsive
nanovehicles
for
co-delivery
TPL
and
Ce6
could
further
enhance
efficacy
this
therapy.
Abstract
Immunotherapy
represents
a
widely
employed
modality
in
clinical
oncology,
leveraging
the
activation
of
human
immune
system
to
target
and
eradicate
cancer
cells
tumor
tissues
via
endogenous
mechanisms.
However,
its
efficacy
remains
constrained
by
inadequate
responses
within
“cold”
microenvironment
(TME).
In
this
study,
multifunctional
nanoscale
pyroptosis
inducer
with
cascade
enzymatic
activity
(IMZF),
comprising
superoxide
dismutase
(SOD),
catalase
(CAT),
peroxidase
(POD),
glutathione
oxidase
(GSHO
x
),
is
dissociated
acidic
glutathione‐rich
TME.
The
vigorous
not
only
generates
oxygen
(O
2
)
alleviate
hypoxia
promote
M2
M1
macrophage
polarization
but
also
yields
reactive
species
(ROS)
depletes
(GSH)
Functioning
as
an
immunogenic
cell
death
(ICD)
activator
inducer,
IMZF
synergistically
triggers
dendritic
maturation
inflammatory
lymphocyte
infiltration
ICD‐associated
pyroptosis,
thereby
reversing
suppression
TMEs.
Consequently,
it
exerts
inhibitory
effects
on
both
primary
distal
tumors.
This
platform‐based
offers
intelligent
strategy
for
effectively
overcoming
tumors,
providing
promising
avenue
advanced
immunotherapeutic
interventions.
Abstract
With
the
development
of
aggregation‐induced
emission
(AIE)
materials,
drawbacks
conventional
fluorescence
materials
subjected
to
aggregation‐caused
quenching
(ACQ)
have
been
resolved.
This
has
allowed
for
improvement
novel
AIE
fluorescent
that
exhibit
enhanced
photostability,
a
higher
signal‐to‐noise
ratio,
and
better
imaging
quality.
Meanwhile,
phototherapeutic
effect
garnered
widespread
attention
in
realm
tumor
treatment.
The
distinct
physiological
anatomical
characteristics
urinary
system
make
it
suitable
use
materials.
Additionally,
AIE‐based
phototherapy
provides
superior
solution
deal
with
weaknesses
treatments
urologic
neoplasms.
In
this
review,
scientific
advancement
on
diseases
since
emergence
concept
is
reviewed
detail.
review
highlights
promise
biomarkers
detection,
(FLI)
vivo
vitro,
phototherapy,
synergistic
therapy
from
both
diagnostic
therapeutic
viewpoints.
It
firmly
believed
hold
immense
untapped
potential
diagnosis
treatment
disease,
as
well
all
human
body.
Abstract
Smart
drug
platforms
based
on
spatiotemporally
controlled
release
and
integration
of
tumor
imaging
are
expected
to
overcome
the
inefficiency
uncertainty
traditional
theranostic
modes.
In
this
study,
a
composite
consisting
thermosensitive
hydrogel
(polyvinyl
alcohol‐carboxylic
acid
(PCF))
multifunctional
nanoparticle
(Fe
3
O
4
@Au/Mn(Zn)‐4‐carboxyphenyl
porphyrin/polydopamine
(FAM
x
P))
is
developed
combine
immunogenic
cell
death
(ICD)/immune
checkpoint
blockade
(ICB)
therapy
under
guidance
magnetic
resonance
(MRI)
fluorescence
(FI).
It
can
not
only
further
recognize
target
cells
through
folate
receptor
cells,
but
also
produce
thermal
dissolution
after
exposure
near‐infrared
light
slowly
FAM
P
in
situ,
thereby
prolonging
treatment
time
avoiding
recurrence.
As
entered
it
released
pH‐dependent
manner.
Chemodynamic,
photothermal
photodynamic
cause
significant
ICD
cancer
cells.
ICB
thus
be
enhanced
by
injecting
anti‐programmed
ligand
1,
improving
effectiveness
treatment.
The
PCF‐FAM
may
represent
an
updated
design
approach
with
simple
compositions
for
cooperative
MRI/FI‐guided
targeted
therapeutic
pathways
tumors.
Advanced Healthcare Materials,
Год журнала:
2023,
Номер
13(1)
Опубликована: Июнь 25, 2023
Pyroptosis
differs
significantly
from
apoptosis
and
cell
necrosis
as
an
alternative
mode
of
programmed
death.
Its
occurrence
is
mediated
by
the
gasdermin
protein,
leading
to
characteristic
outcomes
including
swelling,
membrane
perforation,
release
contents.
Research
underscores
role
pyroptosis
in
etiology
progression
many
diseases,
making
it
a
focus
research
intervention
scientists
explore
ways
regulate
pathways
disease
management.
Despite
numerous
reviews
detailing
relationship
between
mechanisms,
few
delve
into
recent
advancements
nanomaterials
mechanism
for
modulating
pathway
mitigate
effects.
Therefore,
there
urgent
need
fill
this
gap
elucidate
path
use
promising
technology
field
treatment.
This
review
article
delves
developments
management
through
modulation,
details
mechanisms
which
drugs
interact
with
pathways,
highlights
promise
that
nanomaterial
holds
driving
forward
International Journal of Nanomedicine,
Год журнала:
2024,
Номер
Volume 19, С. 3737 - 3751
Опубликована: Апрель 1, 2024
Chemo-photodynamic
combination
therapy
has
demonstrated
significant
potential
in
the
treatment
of
cancer.
Triptolide
(TPL),
a
naturally
derived
anticancer
agent,
when
combined
with
photosensitizer
Chlorin
e6
(Ce6),
shown
to
provide
enhanced
anti-tumor
benefits.
However,
development
stimuli-responsive
nanovehicles
for
co-delivery
TPL
and
Ce6
could
further
enhance
efficacy
this
therapy.
