International Journal of Molecular Sciences,
Год журнала:
2024,
Номер
25(16), С. 8615 - 8615
Опубликована: Авг. 7, 2024
Neural
interfaces
are
crucial
conduits
between
neural
tissues
and
external
devices,
enabling
the
recording
modulation
of
activity.
However,
with
increasing
demand,
simple
no
longer
adequate
to
meet
requirements
for
precision,
functionality,
safety.
There
three
main
challenges
in
fabricating
advanced
interfaces:
sensitivity,
heat
management,
biocompatibility.
The
electrical,
chemical,
optical
properties
2D
nanomaterials
enhance
sensitivity
various
types
interfaces,
while
newly
developed
do
not
exhibit
adverse
reactions
terms
management
Additionally,
can
further
improve
functionality
these
including
magnetic
resonance
imaging
(MRI)
compatibility,
stretchability,
drug
delivery.
In
this
review,
we
examine
recent
applications
focusing
on
their
contributions
enhancing
performance
functionality.
Finally,
summarize
advantages
disadvantages
nanomaterials,
analyze
importance
biocompatibility
testing
propose
that
improving
developing
composite
material
structures
interface
will
continue
lead
forefront
field.
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 26, 2025
Abstract
The
pursuit
of
advanced
neural
interfaces
hinges
on
developing
electrode
materials
with
enhanced
cathodic
charge
storage
capacity
(CSCc),
injection
(CIC),
and
low
impedance.
2D
nanomaterials,
particularly
MXenes,
have
emerged
as
leading
candidates
due
to
their
outstanding
electrical
properties.
However,
current
fabrication
strategies
not
fully
leveraged
the
potential
MXene,
limiting
performance
gains
in
recording
stimulation
applications.
Here,
a
novel
microscale
fiber
(MPP)
engineered
from
Ti₃C₂
MXene
PEDOT‐PSS
using
two‐step
solidification
wet
spinning
process
is
presented.
These
30
µm
fibers
exhibit
conductivity
(2.16
±
1.46)
×
10⁵
S
m
−1
,
interfacial
impedance,
high
CSCc
CIC,
achieving
substantial
improvements
signal
fidelity
efficiency.
MPP
electrodes
demonstrate
robust
electrochemical
stability,
biocompatibility,
magnetic
resonance
imaging
(MRI)
compatibility,
excelling
across
various
modalities,
including
electroencephalography
(EEG),
electromyography
(EMG),
electrocardiography
(ECG),
cortical
recordings,
subthalamic
nucleus
deep
brain
(STN‐DBS).
results
mark
significant
step
toward
scalable,
high‐performance
that
can
transform
neurotherapeutic
Acta Biomaterialia,
Год журнала:
2023,
Номер
175, С. 55 - 75
Опубликована: Дек. 22, 2023
With
the
lack
of
minimally
invasive
tools
for
probing
neuronal
systems
across
spatiotemporal
scales,
understanding
working
mechanism
nervous
system
and
limited
assessments
available
are
imperative
to
prevent
or
treat
neurological
disorders.
In
particular,
nanoengineered
neural
interfaces
can
provide
a
solution
this
technological
barrier.
This
review
covers
recent
surface
engineering
approaches,
including
nanoscale
coatings,
range
topographies
from
microscale
nanoscale,
primarily
focusing
on
neural-interfaced
biosystems.
Specifically,
immobilization
bioactive
molecules
fertilize
cell
lineage,
topographical
induce
mechanotransduction
in
cells,
enhanced
cell-chip
coupling
using
three-dimensional
structured
surfaces
highlighted.
Advances
interface
design
will
help
us
understand
system,
thereby
achieving
effective
treatments
disorders.\
•
focuses
designing
with
chemical
modification
at
multiscale
perspective.
Versatile
coatings
summarized.
Recent
advances
materials
applicable
culture,
electrophysiological
sensing,
implants
reviewed.
ACS Applied Materials & Interfaces,
Год журнала:
2024,
Номер
16(10), С. 12897 - 12906
Опубликована: Фев. 27, 2024
The
"von
Neumann
bottleneck"
is
a
formidable
challenge
in
conventional
computing,
driving
exploration
into
artificial
synapses.
Organic
semiconductor
materials
show
promise
but
are
hindered
by
issues
such
as
poor
adhesion
and
high
elastic
modulus.
Here,
we
combine
polyisoindigo-bithiophene
(PIID-2T)
with
grafted
poly(dimethylsiloxane)
(PDMS)
to
synthesize
the
triblock-conjugated
polymer
(PIID-2T-PDMS).
exhibited
substantial
enhancements
(4.8-68.8
nN)
reductions
modulus
(1.6-0.58
GPa)
while
maintaining
electrical
characteristics
of
PIID-2T.
three-terminal
organic
synaptic
transistor
(three-terminal
p-type
synapse
(TPOAS)),
constructed
using
PIID-2T-PDMS,
exhibits
an
unprecedented
analog
switching
range
276×,
surpassing
previous
records,
remarkable
memory
on-off
ratio
106.
Moreover,
device
displays
outstanding
operational
stability,
retaining
99.6%
its
original
current
after
1600
write-read
events
air.
Notably,
TPOAS
replicates
key
biological
behaviors,
including
paired-pulse
facilitation
(PPF),
short-term
plasticity
(STP),
long-term
(LTP).
Simulations
handwritten
digital
data
sets
reveal
impressive
recognition
accuracy
91.7%.
This
study
presents
polyisoindigo-bithiophene-based
block
copolymer
that
offers
enhanced
adhesion,
reduced
modulus,
high-performance
synapses,
paving
way
for
next
generation
neuromorphic
computing
systems.
Frontiers in Neuroscience,
Год журнала:
2024,
Номер
18
Опубликована: Апрель 15, 2024
Flexible
high-density
microelectrode
arrays
(HDMEAs)
are
emerging
as
a
key
component
in
closed-loop
brain–machine
interfaces
(BMIs),
providing
high-resolution
functionality
for
recording,
stimulation,
or
both.
The
flexibility
of
these
provides
advantages
over
rigid
ones,
such
reduced
mismatch
between
interface
and
tissue,
resilience
to
micromotion,
sustained
long-term
performance.
This
review
summarizes
the
recent
developments
applications
flexible
HDMEAs
BMI
systems.
It
delves
into
various
challenges
encountered
development
ideal
systems
highlights
latest
methodologies
breakthroughs
address
challenges.
These
insights
could
be
instrumental
guiding
creation
future
generations
HDMEAs,
specifically
tailored
use
BMIs.
thoroughly
explores
both
current
state
prospects
advanced
arrays,
emphasizing
their
potential
enhancing
technology.
Microsystems & Nanoengineering,
Год журнала:
2025,
Номер
11(1)
Опубликована: Янв. 23, 2025
Abstract
Precise
and
long-term
electroanalysis
at
the
single-cell
level
is
crucial
for
accurate
diagnosis
monitoring
of
brain
diseases.
The
reliable
protection
in
areas
outside
signal
acquisition
points
sharp
ultramicroelectrode
(UME)
tips
has
a
significant
impact
on
sensitivity,
fidelity,
stability
intracellular
neural
recording.
However,
it
difficult
existing
UMEs
to
achieve
controllable
exposure
tip
functional
structure,
which
affects
their
ability
resist
environmental
interference
shield
noise,
resulting
unsatisfactory
signal-to-noise
ratio
fidelity
recordings.
To
address
this
issue,
we
chose
dense
electrochemically
stable
diamond-like
carbon
(DLC)
film
as
UME
coating
developed
method
precisely
control
exposed
degree
structure
by
directly
fixed-point
processing
strong
site-selectivity
good
controllability
atmospheric
microplasma
jet.
By
analyzing
interaction
between
jet
tip,
well
changes
removal
length
microstructure
with
time,
was
controlled
down
submicron
scale.
Biocompatibility
experiments,
electrochemical
aging
tests
real-time
pH
recording
experiments
have
demonstrated
that
DLC-UME
effective
processed
potential
enable
detection
high-fidelity
signals.
