Chinese Journal of Polymer Science, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 25, 2024
Язык: Английский
Advanced Fiber Materials, Год журнала: 2025, Номер unknown
Опубликована: Апрель 11, 2025
Язык: Английский
Процитировано
0
IGI Global eBooks, Год журнала: 2025, Номер unknown, С. 289 - 326
Опубликована: Апрель 11, 2025
Nanofiber technology presents significant potential across various medical applications, with particular emphasis on its role in wound healing. This chapter examines the ability of nanofibers to mimic extracellular matrix, facilitating critical processes such as cell adhesion, migration, nutrient and oxygen delivery, inflammation modulation, controlled release bioactive molecules. These properties position optimal candidates for advanced dressings, biodegradable scaffolds, cell-seeded constructs. Empirical studies substantiate their efficacy mitigating inflammation, preventing infections, minimizing scar formation. However, challenges persist, including issues related scalability, cost-effectiveness, mechanical stability, biocompatibility, regulatory approval. concludes by addressing these outlining research gaps that must be bridged fully harness nanofiber technology, particularly long-term safety, mechanistic insights, adaptation low-resource settings.
Язык: Английский
Процитировано
0
Advanced Healthcare Materials, Год журнала: 2024, Номер unknown
Опубликована: Сен. 5, 2024
Abstract The treatment of chronic diabetic wounds is a major challenge due to oxidative stress, persistent hyperglycemia, and susceptibility bacterial infection. In this study, multifunctional sandwich‐structured nanofiber dressings (SNDs) are prepared via electrospinning. SNDs consisted an outer layer hydrophobic polylactic acid (PLA) fibers encapsulating MgB 2 nanosheets (MgB NSs), middle PLA polyvinylpyrrolidone (PVP) the NSs metformin hydrochloride complex ‐Met), inner water‐soluble PVP ‐Met. Because their special sandwich structure, have high photothermal conversion efficiency (24.13%) cycle performance. also exhibit effect, bacteria‐targeting effect , electrostatic attraction ability (Met), strong antibacterial activity against Escherichia coli ( E. ) methicillin‐resistant Staphylococcus aureus (MRSA). can eliminate intracellular reactive oxygen species (ROS) by regulating hydrogen release from . addition, good biocompatibility, effectively inhibit inflammatory factor Interleukin‐6 (IL‐6), promote granulation tissue formation, collagen deposition, wound healing. These findings offer promising approach for clinical wounds.
Язык: Английский
Процитировано
3
International Journal of Pharmaceutics, Год журнала: 2024, Номер 669, С. 125108 - 125108
Опубликована: Дек. 20, 2024
Язык: Английский
Процитировано
2
ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(11), С. 6790 - 6813
Опубликована: Окт. 28, 2024
The development of novel wound dressings is critical in medical care. Graphene and its derivatives possess excellent biomedical properties, making them highly suitable for various applications dressings. This review provides a comprehensive technical analysis the current application status graphene-based Initially, we discuss chemical structure fabrication method graphene derivatives. We then provide detailed summary mechanisms by which materials promote repair across four stages healing. Subsequently, categorize types analyze corresponding characteristics. Finally, challenges encountered at present propose solutions regarding future trends. paper aims to serve as reference further research skin tissue engineering innovative
Язык: Английский
Процитировано
1
ACS Nano, Год журнала: 2024, Номер 18(52), С. 35606 - 35619
Опубликована: Дек. 17, 2024
Creating simple methods to produce antioxidant nanozymes with clear structure-activity relationships, particularly aiming improve disinfection and create practical drug formulations for bacterial wound healing, remains a crucial challenge. Herein, we synthesized iron-loaded covalent organic framework nanospheres, which were then controllably transformed into carbon-based nanozyme both iron single atoms clusters through pyrolysis. We discovered that the gradual growth of significantly boosted nanozyme's adsorption onto substrate electron transfer, greatly influencing its activity. The nanozyme, optimized by coexistence Fe4 clusters, exhibited strongest catalase superoxide dismutase enzyme activities as well high photothermal efficiency. Under physiological conditions, peroxidase oxidase enzymatic activities, stimulate oxidative stress, remained low. Furthermore, created an antibacterial self-gelling powder capable dispersing using polyacrylamide poly(acrylic acid). can rapidly gel adhere wet areas, synergistically sterilizing combined actions gel's amino groups effect, while leveraging effects mitigate inflammation. These properties contribute fast healing infectious wounds, thus promising formulation treatment.
Язык: Английский
Процитировано
1
International Journal of Biological Macromolecules, Год журнала: 2024, Номер unknown, С. 136649 - 136649
Опубликована: Окт. 1, 2024
Язык: Английский
Процитировано
0
Chinese Journal of Polymer Science, Год журнала: 2024, Номер unknown
Опубликована: Ноя. 25, 2024
Язык: Английский
Процитировано
0