Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 10, 2024
Abstract
The
diagnosis
and
treatment
of
cancer
face
significant
challenges.
Thus,
precise
controllable
methods
for
effective
tumor
management
are
required.
Sonogenetics
which
combines
ultrasound
technology
with
genetic
engineering
provides
a
promising
solution.
This
approach
utilizes
the
non‐invasive
nature
deep
tissue
penetration
capabilities
to
enable
diagnostics
targeted
therapies
cancer.
review
explores
roles
sonogenetics‐mediated
in
theranostics.
fundamental
properties
mechanisms
underlying
sonogenetics
first
introduced.
Then,
this
work
summarizes
representative
applications
therapy,
including
cell‐based
therapies,
bacteria‐based
eradication
cells.
Additionally,
diagnosis,
focusing
on
engineered
gas
vesicles
(GVs)
situ
generation
GVs
diagnostic
purposes
presented.
Finally,
challenges
clinical
translation
potential
well
discussed.
Journal of Nanotheranostics,
Год журнала:
2025,
Номер
6(2), С. 10 - 10
Опубликована: Апрель 9, 2025
Nanotheranostics—where
nanoscale
materials
serve
both
diagnostic
and
therapeutic
functions—are
rapidly
transforming
gene
therapy
by
tackling
critical
delivery
challenges.
This
review
explores
the
design
engineering
of
various
nanoparticle
systems
(lipid-based,
polymeric,
inorganic,
hybrid)
to
enhance
stability,
targeting,
endosomal
escape
genetic
payloads.
We
discuss
how
real-time
imaging
capabilities
integrated
into
these
platforms
enable
precise
localization
controlled
release
genes,
improving
treatment
efficacy
while
reducing
off-target
effects.
Key
strategies
overcome
barriers
(such
as
proton
sponge
effect
photothermal
disruption)
achieve
nuclear
are
highlighted,
along
with
recent
advances
in
stimuli-responsive
that
facilitate
spatiotemporal
control
expression.
Clinical
trials
preclinical
studies
demonstrate
expanding
role
nanotheranostics
managing
cancer,
inherited
disorders,
cardiovascular
neurological
diseases.
further
address
regulatory
manufacturing
hurdles
must
be
for
widespread
clinical
adoption
nanoparticle-based
therapies.
By
synthesizing
progress
ongoing
challenges,
this
underscores
transformative
potential
effective,
targeted,
image-guided
delivery.
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Дек. 10, 2024
Abstract
The
diagnosis
and
treatment
of
cancer
face
significant
challenges.
Thus,
precise
controllable
methods
for
effective
tumor
management
are
required.
Sonogenetics
which
combines
ultrasound
technology
with
genetic
engineering
provides
a
promising
solution.
This
approach
utilizes
the
non‐invasive
nature
deep
tissue
penetration
capabilities
to
enable
diagnostics
targeted
therapies
cancer.
review
explores
roles
sonogenetics‐mediated
in
theranostics.
fundamental
properties
mechanisms
underlying
sonogenetics
first
introduced.
Then,
this
work
summarizes
representative
applications
therapy,
including
cell‐based
therapies,
bacteria‐based
eradication
cells.
Additionally,
diagnosis,
focusing
on
engineered
gas
vesicles
(GVs)
situ
generation
GVs
diagnostic
purposes
presented.
Finally,
challenges
clinical
translation
potential
well
discussed.
