Advanced Materials Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 5, 2025
Abstract
Poly(ethylene
glycol)‐norbornene
(e.g.,
PEGNB)
is
a
versatile
macromer
amenable
to
step‐growth
thiol‐norbornene
photopolymerization
and
inverse
electron
demand
Diels–Alder
(iEDDA)
click
reaction.
The
translational
potentials
of
PEGNB‐based
hydrogels
have
been
realized
in
the
areas
stem
cell
differentiation,
vitro
disease
modeling,
implantable
therapeutic
devices,
controlled
release
therapeutics.
Even
with
these
advances,
prior
methods
for
synthesizing
PEGNB
all
required
heavy
use
organic
solvents
that
pose
significant
environmental
personal
health
burdens.
Here,
an
all‐aqueous
synthesis
PEG‐amide‐norbornene‐carboxylate
(PEGaNB
CA
)
reported
via
reacting
carbic
anhydride
(CA)
multi‐arm
amino‐terminated
PEG.
Like
previously
ester‐bearing
counterparts
(i.e.,
PEGeNB
),
PEGaNB
readily
crosslinked
into
modular
by
either
or
tetrazine‐norbornene
iEDDA
Unlike
its
counterparts,
provided
long‐term
hydrolytic
stability.
However,
through
blending
hydrolytically
labile
,
can
be
engineered
undergo
tunable
degradation.
versatility
further
demonstrated
high‐fidelity
digital
light
processing
printing
situ
encapsulation
maintenance
human
induced
pluripotent
cells
(hiPSCs).
Materials Today Bio,
Год журнала:
2025,
Номер
31, С. 101503 - 101503
Опубликована: Фев. 6, 2025
Peripheral
nerve
injuries
are
a
prevalent
global
issue
that
has
garnered
great
concern.
Although
autografts
remain
the
preferred
clinical
approach
to
repair,
their
efficacy
is
hampered
by
factors
like
donor
scarcity.
The
emergence
of
guidance
conduits
as
novel
tissue
engineering
tools
offers
promising
alternative
strategy.
This
review
aims
interpret
and
commercialization
from
both
laboratory
perspectives.
To
enhance
comprehension
situations,
this
article
provides
comprehensive
analysis
approved
United
States
Food
Drug
Administration.
It
proposes
initial
six
months
post-transplantation
critical
window
period
for
evaluating
efficacy.
Additionally,
study
conducts
systematic
discussion
on
research
progress
conduits,
focusing
biomaterials
add-on
strategies
pivotal
regeneration,
supported
literature
analysis.
conduit
materials
prospective
optimal
thoroughly
discussed.
strategies,
together
with
distinct
obstacles
potentials
deeply
analyzed.
Based
above
evaluations,
development
path
manufacturing
strategy
envisioned.
conclusion
promoting
summarized
follows:
1)
optimization
fundamental
means;
2)
phased
application
additional
emphasized
direction;
3)
additive
techniques
necessary
tools.
As
result,
findings
provide
academic
practitioners
valuable
insights
may
facilitate
future
endeavors
conduits.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 25, 2025
Engineering
hollow
fibers
with
precise
surface
microstructures
is
challenging;
yet,
essential
for
guiding
cells
alignment
and
ensuring
proper
vascular
tissue
function.
Inspired
by
Euplectella
sponges,
a
novel
strategy
to
engineer
biomimetic
spiral
developed.
Using
oxidized
bacterial
cellulose,
polydopamine,
"brick-and-mortar"
scaffold
created
through
shear
control
during
microfluidic
coaxial
spinning.
The
mimics
natural
extracellular
matrices,
providing
mechanical
stability
supporting
cell
growth.
In
vitro
studies
show
successful
co-culture
of
endothelial
(ECs)
smooth
muscle
(SMCs),
SMCs
aligning
along
ECs
forming
confluent
inner
layer.
vivo
implantation
confirms
biocompatibility,
biodegradability,
low
immunogenicity.
This
Euplectella-inspired
presents
promising
approach
engineering
regenerative
medicine.
Journal of Materials Chemistry B,
Год журнала:
2025,
Номер
unknown
Опубликована: Янв. 1, 2025
Recently,
digital
light
processing
(DLP)
3D
printing
has
garnered
significant
interest
for
fabricating
high-fidelity
hydrogels.
However,
the
intrinsic
weak
and
loose
network
of
hydrogels,
coupled
with
uncontrollable
projection,
leads
to
low
resolution
restricts
their
broader
applications.
Herein,
we
propose
a
straightforward
DLP
strategy
utilizing
in
situ
phase
separation
produce
high-fidelity,
high-modulus,
biocompatible
By
selecting
acrylamide
monomers
poor
compatibility
within
polyvinyl
pyrrolidone
(PVP)
during
polymerization,
create
phase-separated
domains
polyacrylamide
(PAM)
that
effectively
inhibit
ultraviolet
(UV)
transmission.
This
regulation
UV
distribution
results
anhydrous
inks
exceptional
properties:
ultra-high
(1.5
μm),
modulus
(1043
MPa),
high
strength
(70.0
MPa).
Upon
hydration,
hydrogels
decrease
approximately
4000
times
those
gels,
exhibiting
mechano-moisture
sensitivity
suitable
actuator
Additionally,
3D-printed
featuring
micro-scale
structures,
demonstrate
good
biocompatibility
facilitate
nutrient
transport
cell
proliferation.
versatile
paves
way
fabrication
multifunctional
Macromolecular Rapid Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 3, 2025
Abstract
In
order
to
improve
the
disadvantages
of
traditional
hydrogels
such
as
low
mechanical
strength
and
lack
responsiveness,
different
types
nanoparticles
or
nanostructures
are
added
into
hydrogel
network
through
in
situ
polymerization,
self‐assembly
techniques,
other
strategies,
giving
a
variety
special
properties,
stimulation
sensitivity,
optical
electrical
reversibility.
With
development
nano
materials
synthesis
technology,
nanocomposite
have
shown
great
potential
drug
delivery,
tissue
engineering,
motion
detection,
wastewater
treatment,
been
extensively
studied
recent
years.
This
review
comprehensively
elucidates
state‐of‐the‐art
preparation
strategies
underlying
response
mechanisms
diverse
stimulus‐responsive
hydrogels,
spanning
temperature,
pH,
humidity,
electrical,
light
responses.
It
systematically
dissects
their
applications
biomedicine,
environmental
remediation,
flexible
sensing,
composite
phase
change
materials.
Moreover,
it
delves
future
prospects
challenges,
emphasizing
need
for
continuous
innovation
unlock
full
emerging
fields
address
existing
limitations.
Polymers,
Год журнала:
2025,
Номер
17(6), С. 765 - 765
Опубликована: Март 14, 2025
The
architectures
of
hydrogels
fabricated
with
stereolithography
(SLA)
3D
printing
systems
have
played
various
roles
in
bioengineering
applications.
Typically,
the
SLA
successively
illuminated
light
to
a
layer
photo-crosslinkable
hydrogel
precursors
for
fabrication
hydrogels.
These
can
be
classified
into
point-scanning
types
and
digital
micromirror
device
(DMD)
types.
form
layers
by
scanning
focused
light,
while
DMD
illuminate
2D
patterns
each
at
once.
Overall,
were
cost-effective
allowed
good
shape
fidelity
uniform
mechanical
properties.
As
result,
constructs
used
regenerate
tissues
develop
lab-on-a-chip
devices
native
tissue-like
models.
