Cobalt Single‐Atom Intercalation in Molybdenum Disulfide Enhances Piezocatalytic and Enzyodynamic Activities for Advanced Cancer Therapeutics
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 14, 2025
Abstract
Piezoelectric
semiconductor
nanomaterials
have
attracted
considerable
interest
in
piezocatalytic
tumor
treatment.
However,
therapy
encounters
obstacles
such
as
suboptimal
piezoelectric
responses,
rapid
electron‐hole
recombination,
inefficient
energy
harvesting,
and
the
complexities
of
microenvironment.
In
this
study,
sulfur
vacancy‐engineered
cobalt
(Co)
single‐atom
doped
molybdenum
disulfide
(SA‐Co@MoS
2
)
nanoflowers
are
strategically
designed,
which
exhibit
enhanced
effects.
Specifically,
introduction
Co
single
atom
not
only
induces
lattice
distortion
out‐of‐plane
polarization
but
also
leads
to
formation
numerous
vacancies.
These
changes
collectively
narrow
intrinsic
bandgap
material,
facilitating
effective
separation
migration
charge
carriers,
enabling
efficient
production
reactive
oxygen
species
under
ultrasound
stimulation.
Additionally,
SA‐Co@MoS
demonstrate
improved
enzymatic
activity
glutathione
depletion
capabilities
attributed
mixed
valence
states
Co,
intensifying
oxidative
stress
cells,
leading
cell
cycle
arrest
apoptosis,
while
inactivation
peroxidase
4
ferroptosis.
Both
vitro
vivo
results
indicate
that
can
significantly
eliminate
cells.
This
study
offers
valuable
insights
into
exploration
doping‐enhanced
sonosensitizers
for
cancer
treatment,
potentially
paving
way
advancements
field
synergistic
enzyodynamic
therapy.
Язык: Английский
Defect engineering to modulate polarization and electronic structure for efficient piezocatalytic therapy
Nano Today,
Год журнала:
2025,
Номер
61, С. 102666 - 102666
Опубликована: Фев. 15, 2025
Язык: Английский
Emerging Piezoelectric Sonosensitizer for ROS-Driven Sonodynamic Cancer Therapy
Inorganics,
Год журнала:
2025,
Номер
13(3), С. 71 - 71
Опубликована: Фев. 26, 2025
As
a
non-invasive
modality,
sonodynamic
therapy
(SDT)
offers
several
advantages
in
cancer
treatment,
including
deep
tissue
penetration
and
precise
spatiotemporal
control,
resulting
from
the
interplay
between
low-intensity
ultrasound
sonosensitizers.
Piezoelectric
materials,
known
for
their
remarkable
capacity
of
interconversion
mechanical
electrical
energy,
have
garnered
considerable
attention
biomedical
applications,
which
can
serve
as
pivotal
sonosensitizers
SDT.
These
materials
generate
internal
electric
fields
via
ultrasound-induced
deformation,
modulates
alteration
charge
carriers,
thereby
initiating
surface
redox
reactions
to
reactive
oxygen
species
(ROS)
realizing
therapeutic
efficacy
This
review
provides
an
in-depth
exploration
piezoelectric
utilized
SDT,
with
particular
emphasis
on
recent
innovations,
elucidation
underlying
mechanisms,
optimization
strategies
advanced
materials.
Furthermore,
incorporation
immunotherapy,
photodynamic,
chemodynamic,
chemotherapy
is
explored,
emphasizing
potential
enhance
outcomes.
By
examining
basic
principles
effect
its
contributions
this
sheds
light
promising
applications
oncology.
It
also
highlights
future
directions
improving
these
expanding
clinical
utility
tumor
therapy.
Язык: Английский
Dual Piezoelectric Catalytic System for Efficient CO2 Reduction
Green Carbon,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 1, 2025
Язык: Английский
Advancements in research on the precise eradication of cancer cells through nanophotocatalytic technology
Frontiers in Oncology,
Год журнала:
2025,
Номер
15
Опубликована: Апрель 1, 2025
The
rapid
development
of
nanotechnology
has
significantly
advanced
the
application
nanophotocatalysis
in
medical
field,
particularly
for
cancer
therapy.
Traditional
treatments,
such
as
chemotherapy
and
radiotherapy,
often
cause
severe
side
effects,
including
damage
to
healthy
tissues
drug
resistance.
In
contrast,
nanophotocatalytic
therapy
offers
a
promising
approach
by
utilizing
nanomaterials
that
generate
reactive
oxygen
species
(ROS)
under
light
activation,
allowing
precise
tumor
targeting
minimizing
collateral
surrounding
tissues.
This
review
systematically
explores
latest
advancements
highly
efficient
nanophotocatalysts
treatment,
focusing
on
their
toxicological
profiles,
underlying
mechanisms
cell
eradication,
potential
clinical
application.
Recent
research
shows
nanophotocatalysts,
TiO2,
In2O3,
g-C3N4
composites,
along
with
photocatalysts
high
conduction
band
or
valence
positions,
ROS
irradiation,
which
induces
oxidative
stress
leads
apoptosis
necrosis.
These
cellular
interacting
key
biological
molecules
DNA,
proteins,
lipids,
triggering
cascade
biochemical
reactions
ultimately
result
death.
Furthermore,
strategies
S-scheme
heterojunctions
vacancies
(OVs)
have
been
incorporated
enhance
charge
separation
efficiency
absorption,
resulting
increased
generation,
improves
photocatalytic
performance
targeting.
Notably,
these
exhibit
low
toxicity
cells,
making
them
safe
effective
treatment
modality.
also
discusses
challenges
associated
therapy,
limitations
penetration
need
improved
biocompatibility.
findings
suggest
technology
holds
significant
precision
paving
way
safer
more
strategies.
Язык: Английский
Engineering Heterostructured Piezoelectric Nanorods with Rich Oxygen Vacancy‐Mediated Piezoelectricity for Ultrasound‐Triggered Piezocatalytic Cancer Therapy
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Авг. 6, 2024
Abstract
Using
piezoelectric
bionanomaterials
to
promote
the
generation
of
reactive
oxygen
species
(ROS)
is
being
increasingly
recognized
in
ultrasound
(US)‐triggered
tumor
treatments.
The
mechanism
underlying
this
innovative
treatment
involves
US
irradiation,
which
activates
built‐in
electric
field
(BIEF)
and
induces
energy‐band
bending
materials
(PEMs).
In
study,
Sr
0.5
Ba
Nb
2
O
6
(SBN)
nanorods
(NRs)
are
synthesized
using
a
molten
salt
method.
Subsequently,
oxygen‐vacancy
(OV)‐rich
SBN/Sr
7
(SBN/SNO)
heterojunction
nanocomposites
(NCs)
fabricated
via
H
annealing
SBN
NRs.
engineering
strategy
focused
on
enhancing
ROS
generation,
thereby
augmenting
catalytic
activity
NCs.
This
configuration
ensures
that
BIEF
heterojunction‐induced
act
synergistically
provide
sustained
driving
force
for
separation
electron‐hole
(e
−
‐h
+
)
pairs.
Importantly,
OVs
surfaces
‐annealed
NRs
create
electron‐rich
sites,
substantially
enhance
their
piezocatalytic
capabilities.
vitro
vivo
analyses
hepatocellular
carcinoma
(HCC)
models
demonstrate
significant
cytotoxic
tumor‐inhibitory
capabilities
rich
OV‐mediated
sonopiezoelectric
therapy
(SPT)
illustrate
its
potential
as
promising
therapeutic
approach
against
cancer.
Язык: Английский
Drug-device-field Integration for Mitochondria-targeting Dysfunction and Tumor Therapy by Home-tailored Pyroelectric Nanocomposites
Biomaterials,
Год журнала:
2024,
Номер
316, С. 122990 - 122990
Опубликована: Дек. 2, 2024
Язык: Английский
Transition metal doped MoS2 for piezoelectric Fenton-catalyzed degradation of norfloxacin: Rapid innergenerated-H2O2 conversion and dual pathways of non-radicals and radicals
Chemical Engineering Journal,
Год журнала:
2024,
Номер
unknown, С. 159027 - 159027
Опубликована: Дек. 1, 2024
Язык: Английский
Research progress of piezoelectric materials in protecting oral health and treating oral diseases: a mini-review
Frontiers in Bioengineering and Biotechnology,
Год журнала:
2024,
Номер
12
Опубликована: Сен. 13, 2024
Piezoelectric
materials,
as
a
class
of
materials
capable
generating
electrical
charges
under
mechanical
vibration,
have
special
piezoelectric
effects
and
been
widely
applied
in
various
disease
treatment
fields.
People
generate
vibrations
the
oral
cavity
during
daily
activities
such
brushing
teeth,
using
electric
toothbrushes,
chewing,
speaking.
These
natural
(or
external
ultrasound)
provide
ideal
conditions
for
activating
leading
to
their
high
potential
applications
protecting
health
treating
diseases.
Based
on
this,
this
review
reports
research
progress
trends
protection
diseases
past
5
years,
discusses
its
mechanism,
challenges
shortcomings,
aiming
theoretical
basis
new
ideas
future
application
field
cavity.
Finally,
brief
outlook
is
provided,
suggesting
that
may
enable
them
quickly
move
towards
real
clinical
applications.
Язык: Английский