Targeting Synovial Macrophages with Astaxanthin-Loaded Liposomes for Antioxidant Treatment of Osteoarthritis DOI
Linlin Zhao,

Liang-Xiao Li,

Yingyu Zhang

и другие.

ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(11), С. 7191 - 7205

Опубликована: Окт. 16, 2024

Osteoarthritis (OA) is a chronic joint disease highly associated with an imbalance in the network of inflammatory factors and typically characterized by oxidative stress cartilage damage. Moreover, specificity structure makes it difficult for drugs to achieve good penetration effective enrichment cavity. Therefore, therapeutic strategies that increase specific targeting incorporate antioxidative effects are important improve efficacy OA. Here, we developed folic acid-modified liposomal nanoparticle (AST@Lip-FA) loaded antioxidant astaxanthin (AST) enhance water solubility stability AST target delivery site OA, leading significant improvement efficacy. In vitro experiments demonstrated that, due recognition FA receptor folate β on surface activated macrophages, cellular uptake efficiency AST@Lip-FA was increased. Meanwhile, intracellularly overexpressed mediators such as reactive oxygen species nitric oxide were efficiently removed AST@Lip-FA. addition, ACLT-induced OA mouse model, precisely enriched inflamed joints achieved long-term retention, fully utilizing anti-inflammatory, antioxidant, cartilage-protecting effectively alleviate progression summary, has prospect potential strategy

Язык: Английский

Multi‐Enzyme Nanoparticles as Efficient Pyroptosis and Immunogenic Cell Death Inducers for Cancer Immunotherapy DOI Creative Commons

Hekai Yang,

Guangzhao Xu, Fahui Li

и другие.

Advanced Science, Год журнала: 2024, Номер 11(44)

Опубликована: Окт. 9, 2024

Abstract Immunotherapy represents a widely employed modality in clinical oncology, leveraging the activation of human immune system to target and eradicate cancer cells tumor tissues via endogenous mechanisms. However, its efficacy remains constrained by inadequate responses within “cold” microenvironment (TME). In this study, multifunctional nanoscale pyroptosis inducer with cascade enzymatic activity (IMZF), comprising superoxide dismutase (SOD), catalase (CAT), peroxidase (POD), glutathione oxidase (GSHO x ), is dissociated acidic glutathione‐rich TME. The vigorous not only generates oxygen (O 2 ) alleviate hypoxia promote M2 M1 macrophage polarization but also yields reactive species (ROS) depletes (GSH) Functioning as an immunogenic cell death (ICD) activator inducer, IMZF synergistically triggers dendritic maturation inflammatory lymphocyte infiltration ICD‐associated pyroptosis, thereby reversing suppression TMEs. Consequently, it exerts inhibitory effects on both primary distal tumors. This platform‐based offers intelligent strategy for effectively overcoming tumors, providing promising avenue advanced immunotherapeutic interventions.

Язык: Английский

Процитировано

7
Self-Cascade of the Cu/Ce-MOF-808 Nanozyme for One-Step Colorimetric Sensing DOI
Yuan Qin, Hanhua Liang,

Jia Wu

и другие.

Analytical Chemistry, Год журнала: 2025, Номер unknown

Опубликована: Апрель 11, 2025

Natural enzyme cascades, including the same and different kinds of enzymes, have been widely used in biosensing. However, it is still a challenge for nanozymes, mimics natural to achieve biosensing with types enzyme-like activities based on cascade reactions, such as hydrolase oxidoreductase. Considering characteristics multienzyme-like activity some proof concept, this study demonstrates Cu/Ce-MOF-808 nanozyme self-cascade catalyst hydrolase-like catechol oxidase-like activities. Taking organophosphorus pesticides an example, we constructed catalytic reaction one-step colorimetric detection isocarbophos. Specifically, can hydrolyze isocarbophos produce colorless isopropyl salicylate, which further oxidized by complexed 4-aminoantipyrine (4-AAP) red quinoneimine under neutral conditions illumination. Thus, strategy sensitive analysis developed, linear range 0.90-400.00 μg·mL-1 limit 0.42 μg·mL-1. This research presents new approach design synthesis nanozymes has great application potential field

Язык: Английский

Процитировано

0
Bioactive nanocapsules based on lychee-like bilayer structure for synovitis treatment DOI Creative Commons

Wenwen Chai,

Pengfei Tian, Mengke Fan

и другие.

Composites Part B Engineering, Год журнала: 2025, Номер unknown, С. 112303 - 112303

Опубликована: Фев. 1, 2025

Язык: Английский

Процитировано

0
Inverse Oxide/Alloy‐Structured Nanozymes with NIR‐Triggered Enzymatic Cascade Regulation of ROS Homeostasis for Efficient Wound Healing DOI Open Access

Yongsen Zhao,

Shiqi Zhao, Yu Du

и другие.

Advanced Materials, Год журнала: 2025, Номер unknown

Опубликована: Фев. 25, 2025

The precise spatiotemporal control of reactive oxygen species (ROS) generation and scavenging remains pivotal for infected wound healing. However, conventional nanozymes fail to adaptively regulate ROS dynamics across inflammatory proliferative phases. A near-infrared (NIR)-activated inverse oxide/alloy-structured nanozyme (Co7Fe3/ZnO@C) is developed, featuring enzymatic cascade activities tune homeostasis through synergistic chemodynamic (CDT), photodynamic (PDT), photothermal (PTT) therapies. orchestrates a self-regulated cascade: peroxidase (POD)-like activity initially generates bactericidal hydroxyl radicals in acidic wounds, while subsequent NIR triggers hot electron transfer from Co7Fe3 ZnO, facilitating synchronized superoxide dismutase (SOD)-like, catalase (CAT)-like radical antioxidant capacity (HORAC) scavenge residual ROS. This cascaded network dynamically balances production (POD) (NIR-driven SOD/CAT/HORAC), eradicating bacteria resolving inflammation. In vitro/vivo studies have shown that the proposed method maintaining can markedly enhance rate healing by regulation environment within injured tissue facilitation rapid re-epithelialization. work provides an intelligent platform simulates function natural enzymes constructs reaction strategy balance antibacterial anti-inflammatory demands microenvironment.

Язык: Английский

Процитировано

0
Piezoelectric Iridium-Doped Bismuth Ferrite/Sodium Alginate Hydrogel for Antibiosis and Stimulating Osteoblastic Differentiation DOI

Lei Sun,

Weijie Yang,

Shangyu Xie

и другие.

ACS Applied Nano Materials, Год журнала: 2025, Номер unknown

Опубликована: Март 26, 2025

Язык: Английский

Процитировано

0
Intelligent Nanomaterials Design for Osteoarthritis Managements DOI Open Access
Zhihao Chen, Xuan Zheng, Zhengzhi Mu

и другие.

Small Methods, Год журнала: 2025, Номер unknown

Опубликована: Март 30, 2025

Osteoarthritis (OA) is the most prevalent degenerative joint disorder, characterized by progressive degradation, pain, and diminished mobility, all of which collectively impair patients' quality life escalate healthcare expenditures. Current treatment options are often inadequate due to limited efficacy, adverse side effects, temporary symptom relief, underscoring urgent need for more effective therapeutic strategies. Recent advancements in nanomaterials nanomedicines offer promising solutions improving drug bioavailability, reducing effects providing targeted benefits. This review critically examines pathogenesis OA, highlights limitations existing treatments, explores latest innovations intelligent design OA therapy, with an emphasis on their engineered properties, mechanisms, translational potential clinical application. By compiling recent findings, this work aims inspire further exploration innovation nanomedicine, ultimately advancing development personalized therapies.

Язык: Английский

Процитировано

0
Hyaluronic acid-modified PtPdCo-CQ nanocatalyst with triple enzyme-like activities regulates macrophage polarization and autophagy levels for the treatment of rheumatoid arthritis DOI
Lei Zhang,

Guoquan Wu,

Junwei Yao

и другие.

International Journal of Biological Macromolecules, Год журнала: 2025, Номер 309, С. 143143 - 143143

Опубликована: Апрель 14, 2025

Язык: Английский

Процитировано

0
Targeting Synovial Macrophages with Astaxanthin-Loaded Liposomes for Antioxidant Treatment of Osteoarthritis DOI
Linlin Zhao,

Liang-Xiao Li,

Yingyu Zhang

и другие.

ACS Biomaterials Science & Engineering, Год журнала: 2024, Номер 10(11), С. 7191 - 7205

Опубликована: Окт. 16, 2024

Osteoarthritis (OA) is a chronic joint disease highly associated with an imbalance in the network of inflammatory factors and typically characterized by oxidative stress cartilage damage. Moreover, specificity structure makes it difficult for drugs to achieve good penetration effective enrichment cavity. Therefore, therapeutic strategies that increase specific targeting incorporate antioxidative effects are important improve efficacy OA. Here, we developed folic acid-modified liposomal nanoparticle (AST@Lip-FA) loaded antioxidant astaxanthin (AST) enhance water solubility stability AST target delivery site OA, leading significant improvement efficacy. In vitro experiments demonstrated that, due recognition FA receptor folate β on surface activated macrophages, cellular uptake efficiency AST@Lip-FA was increased. Meanwhile, intracellularly overexpressed mediators such as reactive oxygen species nitric oxide were efficiently removed AST@Lip-FA. addition, ACLT-induced OA mouse model, precisely enriched inflamed joints achieved long-term retention, fully utilizing anti-inflammatory, antioxidant, cartilage-protecting effectively alleviate progression summary, has prospect potential strategy

Язык: Английский

Процитировано

3