Endogenous Near‐Infrared Chemiluminescence: Imaging‐Guided Non‐Invasive Thrombolysis and Anti‐Inflammation Based on a Heteronuclear Transition Metal Complex
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 26, 2025
Conventional
therapy
to
treat
thrombi
(blood
clots)
has
significant
limitations:
i)
inflammation;
ii)
bleeding
side
effects;
iii)
re-embolisation,
and
iv)
in
situ
that
are
not
visible.
Here
it
is
reported
Cu2Ir
nanoparticles
(NPs)
with
a
Cu-coordinated
tetraphenylporphyrin
(TPP)
core
cyclometalated
Ir(C^N)2(N^N)
substituents
integrate
long-lived
near-infrared
(NIR)
chemiluminescence
(CL)
imaging,
photothermal
(PTT)
photodynamic
(PDT)
for
thrombolysis,
antioxidant
anti-inflammatory
properties.
Based
on
density
functional
theory
calculations
the
chemiluminescent
reaction
site
between
TPP
peroxynitrite
(ONOO-)
confirmed
first
time.
The
presence
of
transition
metal
significantly
improves
properties
TPP.
Upon
specific
activation
by
ONOO-,
NPs
exhibited
more
than
30-fold
NIR
CL
intensity
NPs,
luminescence
lasted
60
min
allowing
precise
long-lasting
dynamic
tracking
thrombi.
achieved
non-invasive
safe
thrombolytic
triggered
irradiation
at
signaling
site.
72.3%
blood
reperfusion
obtained
nearly
complete
restoration
flow,
re-embolism
prevented
mouse
carotid
artery
model.
Furthermore,
scavenged
excess
reactive
oxygen/nitrogen
species
(RONS)
reduced
inflammatory
factors.
hold
promise
as
single-molecule
strategy
diagnosing
treating
diseases
associated
thrombosis.
Язык: Английский
Manganese Empowered Electronic Modulated Nanocatalysts Facilitate Bone Reconstruction via Osteoclastogenesis Inhibition and Osteogenesis Activation Bistimulatory Strategy
Composites Part B Engineering,
Год журнала:
2025,
Номер
unknown, С. 112364 - 112364
Опубликована: Март 1, 2025
Язык: Английский
Ultrasmall gold-encapsulated mesoporous platinum to promote photodynamic/catalytic therapy through cascade enzyme-like reactions
Journal of Colloid and Interface Science,
Год журнала:
2024,
Номер
680, С. 117 - 128
Опубликована: Ноя. 3, 2024
Язык: Английский
Multiple enzyme-mimic polypeptide based carbon nanoparticles by ROP and Fe coordination for ROS regulation and photo-thermal therapy against bacterial infection
Ya-li Xiang,
Lingling Yan,
Luo-lin Deng
и другие.
International Journal of Biological Macromolecules,
Год журнала:
2024,
Номер
281, С. 136461 - 136461
Опубликована: Окт. 10, 2024
Язык: Английский
HUVECs’ Expressway Based on Magnesium Ion Doped Hierarchical Scaffold for Rapid Angiogenesis and Bone Ingrowth
Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 27, 2024
Abstract
Delayed
union
or
nonunion
remains
an
extremely
challenging
predicament
even
after
the
application
of
currently
available
engineering
scaffolds
for
treatment
critical‐sized
bone
defects.
The
angiogenesis
throughout
artificial
repair
scaffold
to
achieve
“angiogenic‐osteogenic
coupling”
is
regarded
as
effective
approach
solving
this
issue.
newly
formed
blood
vessels
can
accelerate
supply
oxygen
and
nutrients,
thereby
triggering
subsequent
regeneration.
Therefore,
featuring
angiogenic
microenvironment
that
promotes
cell
adhesion
migration
should
be
designed
superior
repair.
Herein,
a
magnesium
ion‐doped
hierarchical
fabricated
using
polymer
blend
system
chitosan/polyethyleneimine
with
inherent
micro‐phase
separation
complexation.
Due
microscopic
sea‐island
structure
stable
doped
ions,
behavior
underwent
significant
transformation.
Meanwhile,
pathways
related
adhesion,
migration,
are
activated,
critical
target
thrombospondin
1
upregulated.
Consequently,
capacity
augmented,
6
times
rate
attained,
human
umbilical
vein
endothelial
cells
significantly
expedited.
Eventually,
rapid
ingrowth
satisfactory
defect
approximated
in
vivo,
making
composite
promising
clinical
candidate
engineering.
Язык: Английский
A Versatile In Situ Precipitation Assisted Direct‐Write‐3D Printing Strategy for Skinless Hierarchical Porous Polymeric Scaffolds
Macromolecular Rapid Communications,
Год журнала:
2024,
Номер
unknown
Опубликована: Сен. 16, 2024
Abstract
Skinless,
hierarchical
porous
3D
polymer
scaffolds
are
of
critical
importance
in
tissue
engineering,
enabling
improved
cell
infiltration,
nutrient,
metabolite
and
energy
exchange,
biomimetic
structures,
crucial
for
regenerative
medicine,
drug
delivery,
advanced
material
applications.
However,
it
is
still
a
great
challenge
to
construct
this
kind
with
traditional
printing
techniques.
Herein,
novel
simple,
versatile
situ
precipitation‐assisted
direct‐write‐3D
strategy
skinless,
reported.
Homogenous
ink
containing
molecularly
dissolved
fructose
(soluble
porogen
molecule)
(whether
hydrophilic,
hydrophobic
or
amphiphilic)
directly
extruded
into
nonsolvent
bath,
where
simultaneously
solidification
the
precipitation
molecules
both
on
exterior
surface
inside
separated
fibers
happen.
Subsequently,
by
simply
leaching
formed
particles,
skinless
polymeric
can
be
obtained.
It
believed
that
printing,
polymer/macromolecule‐based
scaffolds,
especially
biomaterials,
engineering
market
benefit
tremendously
from
simple
approach.
Язык: Английский