Self-assembling natural flavonoid nanomedicines for alveolar macrophage reprogramming by restoring mitochondrial function in acute lung injury therapy
Chemical Engineering Journal,
Год журнала:
2025,
Номер
unknown, С. 160171 - 160171
Опубликована: Фев. 1, 2025
Язык: Английский
Bioactive Peptide Hydrogel Scaffold with High Fluidity, Thermosensitivity, and Neurotropism in 3D Spatial Structure for Promoted Repair of Spinal Cord Injury
Zhengang Sun,
Xin Luan,
Zhenjuan Sun
и другие.
Small,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 8, 2024
Spinal
cord
injury
(SCI)
has
been
considered
a
clinically
challenging
disease
that
is
characterized
by
local
disturbance
of
the
microenvironment,
which
inhibits
post-injury
neural
regeneration.
The
simulation
microenvironment
conducive
to
regeneration
spinal
beneficial
for
SCI
repair.
In
this
study,
bioactive
composite
hydrogels
are
developed
mimic
regenerative
enhanced
fabricated
(CRP)
based
on
chitosan
(CS),
RADA
Язык: Английский
Self‐Enhancing Drug Pair‐Driven Selenium Nanotherapeutics Reverses Microglial Pyroptosis Through NLRP3/Caspase‐1 Pathway and Neuronal Apoptosis for Treatment of Spinal Cord Injury
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 23, 2025
Abstract
Spinal
cord
injury
(SCI)
constitutes
a
critical
occurrence
that
results
in
the
disruption
of
both
motor
and
sensory
functions.
Oxidative
stress‐induced
apoptosis
pyroptosis
have
been
identified
as
contributors
to
neuronal
damage
during
secondary
phase
following
SCI.
Therefore,
this
study
focuses
on
development
self‐enhancing
drug
pair‐driven
selenium
(Se)
nanotherapeutics,
loading
with
2,3,5,6‐tetramethylpyrazine
(TMP)
Ginsenoside
Rg1
(Rg1),
enhance
treatment
The
engineered
LET/TMP/Rg1@Se
NPs
exhibits
remarkable
antioxidant
properties,
effectively
reducing
oxidative
by
minimizing
reactive
oxygen
species
(ROS)
accumulation
restoring
mitochondrial
function.
In
addition
their
effects,
nanotherapeutics
demonstrates
significant
anti‐pyroptotic
effects
BV2
microglial
cells
modulating
NLRP3/caspase‐1
pathway,
leading
decreased
release
pro‐inflammatory
cytokines
IL‐1β
IL‐18.
Moreover,
inhibition
inflammatory
cascade
response
diminishes
neuroinflammation‐induced
promotes
axonal
regeneration
neurons
vitro.
mouse
model
SCI,
improved
function
regeneration,
attributed
pyroptosis,
highlighting
scientific
basis
for
synergistic
effect
Se
an
innovative
strategy
effective
SCI
therapy.
Язык: Английский
Microenvironment‐Responsive Injectable Conductive Hydrogel for Spinal Cord Injury Repair
Qi Liu,
Wanshun Wang,
Haimei Yang
и другие.
Advanced Functional Materials,
Год журнала:
2024,
Номер
34(46)
Опубликована: Окт. 12, 2024
Abstract
Spinal
cord
injury
(SCI)
represents
a
severe
neurological
condition
often
coupled
with
drastic
secondary
inflammatory
response,
which
further
exacerbates
the
damage
in
most
cases.
Due
to
their
unique
electrical
and
mechanical
compatibilities
spinal
cord,
utilization
of
conductive
hydrogels
through
injection
for
SCI
repair,
particularly
scenarios
involving
non‐uniform
large
gaps,
has
emerged
as
promising
approach.
Herein,
leveraging
acidic
microenvironment
characteristic
acute
sites,
an
injectable
hydrogel
pH‐responsive
immunoregulation
is
engineered
repair.
Based
on
dynamic
Schiff
base
chemistry
covalent
photo‐crosslinking,
this
composite
hydrogel,
composed
gelatin
methacryloyl,
oxidized
dextran,
MoS
2
,
exhibits
adjustable
properties,
enabling
customized
match
natural
cord's
attributes.
Additionally,
incorporation
Wnt5a
its
selective
release
conditions
prompt
immediate
suppression
factors
enhances
neural
differentiation
regeneration.
In
2‐mm
hemisection
mouse
model,
optimized
can
effectively
bridge
gap,
establish
nerve
connections
signal,
mitigate
promoted
recovery
mobility.
This
novel
system
offers
advance
therapeutic
materials
Язык: Английский
Regulation of dynamic spatiotemporal inflammation by nanomaterials in spinal cord injury
Journal of Nanobiotechnology,
Год журнала:
2024,
Номер
22(1)
Опубликована: Дек. 19, 2024
Spinal
cord
injury
(SCI)
is
a
common
clinical
condition
of
the
central
nervous
system
that
can
lead
to
sensory
and
motor
impairment
below
level
or
permanent
loss
function
in
severe
cases.
Dynamic
spatiotemporal
neuroinflammation
vital
neurological
recovery,
which
collectively
constituted
by
dynamic
changes
series
inflammatory
cells,
including
microglia,
neutrophils,
astrocytes,
among
others.
Immunomodulatory
nanomaterials
readily
improve
therapeutic
effects
simultaneously
overcome
various
drawbacks
associated
with
treatment,
such
as
off-target
side
bioactivity
immune
agents
during
circulation.
In
this
review,
we
discuss
role
inflammation
secondary
injuries
after
SCI,
elaborate
on
mechanism
action
effect
existing
treating
summarize
mechanism(s)
whereby
they
regulate
inflammation.
Finally,
challenges
prospects
using
nanotechnology
modulate
immunotherapy
are
discussed
provide
new
insights
for
future
treatment.
Deciphering
intricate
mechanisms
SCI
requires
further
in-depth
studies.
Therefore,
continues
represent
formidable
challenge.
Язык: Английский