Nanoscale Advances, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Recent focus on sustainable nanoparticle synthesis highlights bioinspired nano-antimicrobials advantages over chemically synthesized counterparts. This study pioneers the green of porphyrinic nanocubes, demonstrating potent antibacterial activity through sono-photodynamic inactivation. approach holds promise in combating antibiotic resistance.
Язык: Английский
Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161341 - 161341
Опубликована: Март 1, 2025
Язык: Английский
Процитировано
0
Aggregate, Год журнала: 2025, Номер unknown
Опубликована: Апрель 11, 2025
ABSTRACT Sonodynamic therapy (SDT) is an innovative cancer modality that harnesses the energy of ultrasound to activate sonosensitizers for producing reactive oxygen species (ROS), culminating in eradication tumor cells. Compared with photodynamic therapy, SDT has capacity penetrate deeply into biological tissues, thereby holding significant promise addressing situated or surgically inaccessible tumors. The effectiveness greatly dependent on characteristics sonosensitizers, and unlike inorganic organic offer a more controlled synthesis process have excellent biocompatibility. This review presents meticulous undertaking categorize elucidate their mechanisms action therapeutic effects context SDT. Design strategies are also summarized, we emphasize critical role nanotechnology localization, imaging, multimodal synergistic offering approach achieving precise targeting. In addition, impact delineated when integrated other oncological modalities, such as photothermal enhance efficacy. Finally, discusses challenges future perspectives advancement clinical within realm oncology.
Язык: Английский
Процитировано
0
Materials Today Bio, Год журнала: 2024, Номер 30, С. 101407 - 101407
Опубликована: Дек. 15, 2024
Cell membrane targeting sonodynamic therapy could induce the accumulation of lipid peroxidation (LPO), drive ferroptosis, and further enhances immunogenic cell death (ICD) effects. However, ferroptosis is restrained by suppressor protein 1 (FSP1) at plasma membrane, which can catalyze regeneration ubiquinone (CoQ10) using NAD(P)H to suppress LPO accumulation. This work describes construction US-active nanoparticles (TiF NPs), combinate cell-membrane sonosensitizer TBT-CQi with FSP1 inhibitor (iFSP1), facilitating sonodynamic-triggered ferroptosis. TiF NPs a effect, promotes drives apoptosis. Furthermore, FSP1, CoQ10 depletion, down-regulate NADH, enhance accumulation, finally In vitro results demonstrated that synergetic SDT/FSP1 inhibition triggered (ICD). Moreover, as-synthesized NPs-mediated thoroughly inhibited tumor growth simultaneously activated antitumor immunity lung metastasis. represents promising therapeutic strategy combining SDT inhibition, potentially inspiring research in developing logical effective cancer therapies based on synergistic SDT/ferroptosis.
Язык: Английский
Процитировано
1
Nanoscale Advances, Год журнала: 2024, Номер unknown
Опубликована: Янв. 1, 2024
Recent focus on sustainable nanoparticle synthesis highlights bioinspired nano-antimicrobials advantages over chemically synthesized counterparts. This study pioneers the green of porphyrinic nanocubes, demonstrating potent antibacterial activity through sono-photodynamic inactivation. approach holds promise in combating antibiotic resistance.
Язык: Английский
Процитировано
0