Advanced Functional Materials,
Год журнала:
2024,
Номер
unknown
Опубликована: Ноя. 17, 2024
Abstract
Reactive
oxygen
species
(ROS)
have
been
growing
as
an
emerging
“hot”
topic
in
antimicrobial
applications.
However,
optimizing
activity
by
enhancing
ROS
generation
remains
a
formidable
challenge.
Here,
using
bassanite
proof
of
concept,
the
facet
engineering
matrix
can
enhance
efficiency
via
tuning
d
‐band
center
Cu
atom
is
proposed.
Theoretical
calculation
and
experimental
investigations
reveal
that
atoms
significantly
shifted
upward
when
doped
into
(204)
compared
to
(400)
facet.
A
higher
facilitates
adsorption
activation
between
O
2
through
formation
stronger
‐
π
*
orbital
hybridization,
resulting
increased
production.
Through
engineering,
material
exhibits
better
facet,
which
presents
clear
potential
construction
materials
personal
protection.
This
work
shed
light
on
designing
new
with
high
application
engineering.
The Journal of Physical Chemistry Letters,
Год журнала:
2025,
Номер
unknown, С. 3945 - 3953
Опубликована: Апрель 10, 2025
Revealing
the
regulatory
mechanism
underlying
cytotoxicity
and
hemocompatibility
of
nanocarriers
is
crucial
for
their
biofunctionalized
design
practical
application
in
nanotherapeutics.
However,
microstructural
physicochemical
properties
inevitably
change
during
modification
process,
impact
these
changes
on
biosafety
remains
unclear.
Herein,
we
investigate
effects
phase
transformation
kaolinite
(Kaol)
nanoclay
its
biosafety.
Experimental
results
indicate
that
adjoint
dehydration,
dehydroxylation,
disaggregation
Kaol
could
alter
mode
interaction
at
cell
interface
mitigate
damage
to
membranes.
Furthermore,
heat-treated
exhibits
reduced
hemolysis
while
maintaining
red
blood
adhesion
pro-coagulant
functions,
without
affecting
structure
plasma
proteins.
Collectively,
this
study
provide
a
novel
insight
into
correlation
between
microstructure
The
crystalline
phase
of
metal
oxides
is
a
key
determinant
the
properties
and
functions
nanomaterials.
Traditional
approaches
have
focused
on
replicating
bulk-phase
structures,
with
limited
exploration
diversity
due
to
challenges
in
controlling
crystal
morphology.
Here,
we
introduce
nanoclay-mediated
strategy
for
crystal-phase
engineering,
using
talc
modulate
morphology
manganese
oxide
(MnOx)
nanoparticles.
This
approach
enhances
oxidase
activity
MnOx
composite
(M/T),
optimizing
antimicrobial
efficacy
while
minimizing
cytotoxicity.
M/T-190
demonstrated
99%
bactericidal
against
Escherichia
coli
Staphylococcus
aureus,
coupled
84%
cytocompatibility.
Theory
calculations
suggest
that
modulates
charge
distribution
d-band
center
tuning
at
Mn3O4/MnOOH
interface,
enhancing
oxygen
activation.
When
integrated
into
gauze,
M/T
exhibits
strong
activity,
low
toxicity,
promotes
wound
healing
both
vitro
vivo
studies.
These
findings
highlight
potential
natural
minerals
engineering
biomedical
applications.
Inorganics,
Год журнала:
2025,
Номер
13(3), С. 71 - 71
Опубликована: Фев. 26, 2025
As
a
non-invasive
modality,
sonodynamic
therapy
(SDT)
offers
several
advantages
in
cancer
treatment,
including
deep
tissue
penetration
and
precise
spatiotemporal
control,
resulting
from
the
interplay
between
low-intensity
ultrasound
sonosensitizers.
Piezoelectric
materials,
known
for
their
remarkable
capacity
of
interconversion
mechanical
electrical
energy,
have
garnered
considerable
attention
biomedical
applications,
which
can
serve
as
pivotal
sonosensitizers
SDT.
These
materials
generate
internal
electric
fields
via
ultrasound-induced
deformation,
modulates
alteration
charge
carriers,
thereby
initiating
surface
redox
reactions
to
reactive
oxygen
species
(ROS)
realizing
therapeutic
efficacy
This
review
provides
an
in-depth
exploration
piezoelectric
utilized
SDT,
with
particular
emphasis
on
recent
innovations,
elucidation
underlying
mechanisms,
optimization
strategies
advanced
materials.
Furthermore,
incorporation
immunotherapy,
photodynamic,
chemodynamic,
chemotherapy
is
explored,
emphasizing
potential
enhance
outcomes.
By
examining
basic
principles
effect
its
contributions
this
sheds
light
promising
applications
oncology.
It
also
highlights
future
directions
improving
these
expanding
clinical
utility
tumor
therapy.
ACS Applied Materials & Interfaces,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 23, 2025
Oxidative
stress
derived
from
excess
reactive
oxygen
radicals
(ROS)
induces
cellular
damage,
apoptosis,
and
necrosis,
thus
effective
biofouling
control
by
directly
inhibiting
primary
membrane
formation.
However,
the
oxidative
produced
that
does
not
rely
on
additional
energy
still
is
a
challenge.
Herein,
an
oxidative-stress-mediated
marine
antifouling
polyurea
coating
prepared
leveraging
strong
electron
absorption
effect
of
C═N.
Given
structure
urethane
bond,
reversible
reaction
barrier
dynamic
bond
can
be
reduced,
thereby
enabling
to
broken
without
need
for
energy.
The
alkyl
radical
(R·)
originating
oxime-urethane
mediate
induction
in
cells
microbial
death,
preserving
exceptional
properties
resisting
most
organism
adhere
substrates.
Notably,
indicates
satisfactory
antibacterial
antialgae
performance
exhibits
8
months
field
performance.
In
addition,
investigated
theoretical
calculation,
interface
behavior
molecular
dynamics
simulation.
This
work
presents
pioneering
example
construction
coating,
which
might
judicious
design
strategy
environmentally
friendly
coating.
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Март 27, 2025
Abstract
Conventional
antimicrobials
typically
exhibit
suboptimal
deposition
on
rice
leaves,
resulting
in
poor
efficacy,
further
impaired
by
biofilms
and
Type
III
Secretion
Systems
(T3SS).
Herein,
this
study
presents
a
supramolecular
strategy
to
fabricate
BtP27@
β
‐CD,
sunflower‐like
material
engineered
through
host‐guest
recognition
between
de
novo
designed
molecule
BtP27
‐cyclodextrin.
‐CD
manifests
enhanced
foliar
affinity
vivo
efficiency,
demonstrating
superior
protective
(62.67%)
curative
(51.16%)
activities
against
bacterial
leaf
blight
at
low‐dose
of
200
µg
mL
−1
compared
commercial
thiodiazole‐copper
(37.78%/38.13%)
without
compromising
safety.
This
multifunctional
material,
structurally
derived
from
dufulin,
inherit
progenitor's
systemic
conductive
properties,
alongside
the
capacity
activate
salicylic
acid‐mediated
plant
defense
pathways.
Moreover,
it
is
endowed
with
anticipated
abilities
disorganize
biofilm
barriers,
annihilate
encased
pathogens,
inhibit
T3SS.
constitutes
inaugural
report
supramolecular‐based
biofilm/T3SS
dual
inhibitor.
An
expanded
investigation
into
substrate
indication
screening
identified
additional
molecules
that
self‐assemble
‐cyclodextrin
form
materials,
exhibiting
potency
other
diseases,
ranging
63.53%
73.30%
efficacy
spanning
42.18%
60.41%
.
In
brief,
work
establishes
paradigm
for
designing
guest
scratch
construct
materials
tailored
characteristics.
Nano Letters,
Год журнала:
2024,
Номер
24(46), С. 14812 - 14820
Опубликована: Ноя. 5, 2024
Photothermal
therapy
(PTT)
is
an
efficient
way
to
combat
bacterial
infections
and
circumvent
multidrug
resistance.
However,
balancing
efficacious
killing
minimizing
damage
the
surrounding
normal
tissues
remain
a
great
challenge.
Herein,
highly
cooperative
Prussian
blue/kaolinite
(PB/Kaol)
hybrid
nanosystem
constructed
for
antibacterial
accelerate
healing
of
infected
wounds.
After
hybridization
with
Kaol,
prepared
PB/Kaol
forms
interfacial
Al-O-Fe
bonds,
fast
charge
transfer
channel
from
Kaol
PB,
which
contributes
enhanced
photothermal
effect
PB/Kaol.
Additionally,
hydroxyl
Lewis
acid-base
sites
surface
could
promote
adhesion
bacteria,
thereby
ensuring
that
as
much
hyperthermia
possible
focused
on
bacteria
healthy
tissues.
Furthermore,
inherits
anti-inflammatory
hemostasis
functions
PB
resulting
in
rapid
