A Copper‐Manganese Based Nanocomposite Induces Cuproptosis and Potentiates Anti‐Tumor Immune Responses

Small, Год журнала: 2025, Номер unknown

Опубликована: Фев. 16, 2025

Cancer is one of the most important challenges worldwide with an increasing incidence. However, patients malignant cancer receiving traditional therapies have tumor recurrence and short-term 5-year survival. Herein, a novel Cu2O-MnO@PEG (CMP) nanomaterial developed to treat tumors. CMP directly mediates cuproptosis in cells. Meanwhile, potentiates anti-tumor immune responses microenvironment (TME) induce regression. improves antigen processing presentation dendritic cells tumor-associated macrophages, further promotes CD8+ T cell responses, especially for cytotoxic transitory exhausted Additionally, downregulates proportion Treg CTLA-4 expression on Notably, induces systemic against distant tumors long-term memory. Furthermore, synergized PD-L1 mAb inhibition sustains efficacy post treatment. Collectively, this strategy has clinically therapeutic potential by facilitating responses.

Язык: Английский

Photothermally inducing SnS2 phase transition in Cu2O@CuS@SnS2 core–shell heterostructure to trigger efficient photocatalytic CO2 reduction

Chemical Engineering Journal, Год журнала: 2025, Номер unknown, С. 161537 - 161537

Опубликована: Март 1, 2025

Язык: Английский

Multifunctional Cascade Theranostic Agents for Synergistic Photothermal/Ferroptosis/Immuno Antitumor Therapy

Colloids and Surfaces B Biointerfaces, Год журнала: 2025, Номер unknown, С. 114740 - 114740

Опубликована: Апрель 1, 2025

Язык: Английский