New horizons for the therapeutic application of nanozymes in cancer treatment
Journal of Nanobiotechnology,
Год журнала:
2025,
Номер
23(1)
Опубликована: Фев. 20, 2025
The
advent
of
nanozymes
has
revolutionized
approaches
to
cancer
diagnosis
and
therapy,
introducing
innovative
strategies
that
address
the
limitations
conventional
treatments.
Nanozyme
nanostructures
with
enzyme-mimicking
catalytic
abilities
exhibit
exceptional
stability,
biocompatibility,
customizable
functions,
positioning
them
as
promising
tools
for
theranostics.
By
emulating
natural
enzyme
reactions,
can
selectively
target
eradicate
cells,
minimizing
harm
adjacent
healthy
tissues.
Nanozymes
also
be
functionalized
specific
targeting
ligands,
allowing
precise
delivery
regulated
release
therapeutic
agents,
improving
treatment
effectiveness
reducing
adverse
effects.
However,
issues
such
selectivity,
regulatory
compliance
remain
critical
challenges
clinical
application
nanozymes.
This
review
provides
an
overview
nanozymes,
highlighting
their
unique
properties,
various
classifications,
activities,
diverse
applications
in
strategic
oncological
deployment
could
profoundly
impact
future
advancements
personalized
medicine,
recent
progress
prospective
directions
enzyme-mimetic
treatment.
summarizes
Язык: Английский
Zinc Cerium Peroxide Antibacterial Agent with Acid-Activated Cascade Multienzymatic Activities
ACS Applied Nano Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 2, 2025
Recently,
metal
peroxides
with
the
ability
to
self-supply
H2O2
have
been
intensively
used
in
antibacterial
and
cancer
therapy.
However,
performances
are
unsatisfactory
due
low
efficiency
of
peroxide-mediated
Fenton-like
reaction.
In
this
work,
a
novel
zinc
cerium
bimetallic
peroxide
(CeZnOx)
has
first
reported,
which
possesses
acid-activated
POD-like,
OXD-like,
CAT-like
multienzymatic
activities
for
efficiently
bacterial
inhibition.
Specifically,
CeZnOx
self-supplying
under
weakly
acidic
conditions
subsequently
catalyzes
production
reactive
oxygen
species
(ROS)
through
synergistically
enhanced
POD-like
OXD-like
activity.
They
can
also
exhibit
activity
catalyze
excessive
into
O2
play
an
anti-inflammatory
role
normal
pH
conditions.
The
cascade
inhibit
growth
alleviate
hypoxia,
improving
microenvironment
at
wound
site.
As
expected,
exhibits
superior
effect
on
Staphylococcus
aureus
Escherichia
coli.
Therefore,
CeZnOx-mediated
offer
simple
promising
strategy
efficient
treatment
infections.
Язык: Английский
COF‐Derived Carbon Materials: Synthesis Strategies and Emerging Applications
Macromolecular Rapid Communications,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 11, 2025
Covalent
organic
framework
(COF)-derived
carbon
materials
seamlessly
inherit
the
periodic
porous
architecture
and
high
specific
surface
area
of
their
precursors,
while
simultaneously
enabling
confinement
nanoparticles
in
designated
regions.
This
unique
feature
mitigates
agglomeration,
enhances
intrinsic
properties,
imparts
novel
functionalities
to
resulting
materials.
Consequently,
COF-derived
have
garnered
significant
attention
across
diverse
fields,
including
energy,
environmental
remediation,
biomedical
applications.
Despite
this
burgeoning
interest,
a
comprehensive
review
encompassing
synthesis,
classification,
multifaceted
applications
these
remains
scarce.
In
context,
state-of-the-art
advancements
are
reviewed
systematically
here.
It
categorizes
materials,
delineates
primary
synthesis
strategies,
highlights
versatile
catalysis,
electrochemical
energy
storage,
water
treatment,
sensing,
cancer
therapy.
Lastly,
fresh
insights
into
challenges
future
prospects
paving
way
for
expanded
exploration
utilization
offered
Язык: Английский
Reprogramming Lung Redox Homeostasis by NIR Driven Ultra‐Small Pd Loaded Covalent Organic Framework Inhibits NF‐κB Pathway for Acute Lung Injury Immunotherapy
Advanced Science,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 18, 2025
Abstract
Acute
lung
injury
(ALI)
refers
to
damage
related
cells,
typically
caused
by
an
uncontrollable
inflammatory
response,
and
over‐generated
reactive
oxygen
species
(ROS).
Increasing
evidence
suggests
that
reprogramming
redox
homeostasis
holds
significant
potentials
for
the
clinical
treatment
of
ALI.
Herein,
simple
synthesis
ultra‐small
Pd
loaded
covalent
organic
framework
(COF)
(TP@Pd)
is
reported,
which,
when
combined
with
near
infrared
(NIR)
irradiation,
exhibits
nanozyme
functionalities,
including
multiple
enzyme
mimicking
activities
broad
spectrum
ROS
scavenging,
thereby
promoting
tissue
repair
ALI
immunotherapy.
Mechanistically,
through
therapeutic
strategy
TP@Pd+NIR,
damaged
cells
tissues
are
ameliorated
decreasing
intracellular
levels
(total
ROS,
·OH
·O
2
−
),
downregulating
cytokines
(IL‐6,
TNF‐α
IL‐1β),
upregulating
antioxidant
factor
level
(SOD2),
inducing
macrophage
M2
directional
polarization
(downregulation
iNOS
CD86,
upregulation
IL‐10
CD206),
activating
immunoregulation
(CD4
+
/CD8
ratio
increase),
(upregulation
HSP70
CD31),
suppressing
NF‐κB
signaling
pathway
phosphorylated
p65
IκBα).
Furthermore,
following
intravenous
(IV)
injection
in
rats,
TP@Pd
accumulated
6
h,
indicating
promising
efficacy
via
this
administration
route.
Notably,
TP@Pd+NIR
demonstrated
excellent
synergistic
effects
alleviating
inflammation
storms,
reducing
diffuse
alveolar
damage,
accelerating
repair.
Summarily,
work
has
designed
a
novel
enhancement
amelioration,
which
may
serve
as
approach
other
diseases.
Язык: Английский
Microenvironment‐Responsive Injectable Thermosensitive Hydrogel Incorporating Nanozymes for Synergistic Breast Cancer Therapy and Postsurgical Adjuvant Treatment
Advanced Functional Materials,
Год журнала:
2025,
Номер
unknown
Опубликована: Фев. 23, 2025
Abstract
Tumor
recurrence
and
wound
infection
present
significant
challenges
to
patient
recovery
following
surgery,
underscoring
the
need
for
effective
therapeutic
strategies
improve
prognosis
by
mitigating
these
complications.
This
study
introduces
novel
synthesis
methods
honeycomb‐like
CuMnOx
nanozymes
CuO
2
nanoflowers
with
multienzymatic
activity
pH‐responsive
properties.
The
enzymatic
activities
of
can
be
regulated
pH
changes
in
tumor
or
microenvironments,
while
overcome
limitation
insufficient
endogenous
H
O
release
ROS
weakly
acidic
conditions.
To
realize
their
synergistic
effects,
nanozymes,
along
photothermal
agent
IR820,
are
co‐assembled
into
low‐melting
point
agarose
solution,
forming
a
thermosensitive
nanozyme‐based
hydrogel
(CuMnOx@CuO
@IR820
hydrogel,
CMCI
Gel),
which
facilitates
controlled
drug
delivery
exerts
enhanced
efficiency
under
low‐temperature
therapy
(LTPTT,
<48
°C).
In
vitro
vivo
studies
demonstrated
that
Gel
effectively
ablated
cells
range
bacteria,
including
drug‐resistant
bacteria
like
MRSA
.
Furthermore,
it
reduces
inflammation,
promotes
vascular
regeneration
collagen
deposition,
accelerates
healing.
injectability
thermosensitivity
allow
localized
treatment,
minimizing
systemic
side
effects.
Overall,
benefits
highlight
as
promising
adjunctive
prevent
postsurgery
infection.
Язык: Английский
Homologous-adhering/targeting cell membrane- and cell-mediated delivery systems: a cancer-catch-cancer strategy in cancer therapy
Regenerative Biomaterials,
Год журнала:
2024,
Номер
12
Опубликована: Ноя. 20, 2024
Abstract
Low
tumor
enrichment
remains
a
serious
and
urgent
problem
for
drug
delivery
in
cancer
therapy.
Accurate
targeting
of
sites
is
still
critical
aim
Though
there
have
been
variety
strategies
to
improve
the
enrichment,
biological
barriers
cause
most
delivered
guests
fail
or
be
excreted
before
they
work.
Recently,
cell
membrane-based
systems
attracted
huge
amount
attention
due
their
advantages
such
as
easy
access,
good
biocompatibility
immune
escape,
which
contribute
biomimetic
structures
specific
surface
proteins.
Furthermore,
are
referred
homologous-targeting
function
exhibit
significantly
high
adhesion
internalization
homologous-type
cells
even
though
exact
mechanism
not
entirely
revealed.
Here,
we
summarize
sources
characterizations
membrane
systems,
including
reconstructed
single
hybrid
nano-/microcarriers,
well
engineered
cells.
Additionally,
advanced
applications
these
therapy
categorized
summarized
according
components
membranes.
The
potential
factors
related
homologous
also
discussed.
By
discussing
applications,
challenges
opportunities,
expect
far-reaching
development
preclinic
clinics.
Язык: Английский