Gels, Год журнала: 2025, Номер 11(3), С. 217 - 217
Опубликована: Март 20, 2025
Efficient and precise cancer therapy remains a challenge due to limitations in current treatment modalities. In this study, we developed multifunctional hydrogel system that integrates photothermal (PTT) chemotherapy achieve combined tumor treatment. The hydrogel, composed of γ-polyglutamic acid (γ-PGA), fifth-generation polyamide-amine dendrimers (G5), polydopamine (PDA) nanoparticles, exhibits high conversion efficiency temperature-responsive drug release properties. exhibited 45.6% under 808 nm near-infrared (NIR) irradiation. Drug studies demonstrated cumulative hydrophilic anticancer doxorubicin DOX 79.27% within 72 h mild hyperthermia conditions (50 °C). vivo experiments revealed significant inhibition rate 82.3% with minimal systemic toxicity. Comprehensive vitro evaluations reveal the demonstrates excellent biocompatibility, stability, biodegradability. Unlike conventional systems, our γ-PGA-based uniquely biocompatible biodegradable polymer providing smart responsive platform for therapy. This represents promising combines PTT precision efficacy, robust strategy advanced safer
Язык: Английский